Jorge J. Gumucio, Paolo Gentilini – 1 May 1991 – Plasma levels of canrenone and androgen receptoractive materials (ARM) were determined during long‐term oral K‐canrenoate or spironolactone therapy in cirrhotics with chronic recurrent ascites. Mean plasma canrenone level was approximately 3 times higher under K‐canrenoate than under spironolactone treatment; moreover, the levels were not dose related. Either type of treatment did not affect plasma aldosterone and testosterone concentrations.

Anna S. F. Lok, Ching‐Lung Lai, Hau‐Tim Chung, Johnson Y. N. Lau, Elsie K. Y. Leung, Loretta S. K. Wong – 1 May 1991 – Three‐hundred forty‐one HBsAg‐positive family members of 152 patients with chronic hepatitis B virus infection (47 asymptomatic carriers, 59 with chronic hepatitis, 17 with cirrhosis and 29 with hepatocellular carcinoma) were prospectively studied to determine the morbidity and mortality from chronic hepatitis B virus infection in the family members of patients with malignant and nonmalignant hepatitis B virus–related chronic liver diseases.

Ulrik Becker, Thomas Almdal, Erik Christensen, Christian Gluud, Stense Farholt, Paul Bennett, Birgit Svenstrup, Finn Hardt – 1 May 1991 – To evaluate serum sex hormone profiles in nonalcoholic postmenopausal women with liver disease, 25 women with primary biliary cirrhosis (11 in cirrhotic stage) and 46 healthy controls were studied.

Desmond H. Birkett – 1 May 1991

Riccardo Volpes, Joost J. van den Oord, Valeer J. Desmet – 1 May 1991 – T cells can be divided into two main phenotypic subpopulations–i.e., the CD45RA‐positive (2H4‐positive) “naive” subset and the CD45RO‐positive (UCHL1‐positive) “memory” subset.

Shou‐Dong Lee, Cho‐Yu Chan, Yan‐Jenn Wang, Jaw‐Ching Wu, Kwok‐Hung Lai, Yang‐Te Tsai, Kwang‐Juei Lo – 1 May 1991 – The prevalence of antibody to hepatitis C virus among Chinese subjects in Taiwan was evaluated using a commercially available enzyme immunoassay. The overall prevalence of antibody to hepatitis C virus was 0.28% among 1,419 healthy subjects, 0.8% among 500 unselected paid blood donors and 0.4% among 793 pregnant women.

Raymond S. Koff – 1 May 1991

Robert G. Paul, Stanford T. Roodman, Carolyn R. Campbell, Carol J. Bodicky, Robert P. Perrillo – 1 May 1991 – HLA class I antigen expression on peripheral blood mononuclear cells was evaluated by flow cytometry in 21 HBeAg‐positive patients with chronic hepatitis B. Measurements were made before, during or after treatment with recombinant interferon‐α‐2b, either given alone or after a 6 wk course of prednisone.

Karl E. Anderson, Reneé B. McCleery, Elliot S. Vesell, Florence F. Vickers, Attallah Kappas – 1 May 1991 – This study compared the effects of diet and cimetidine on theophylline metabolism and examined interactions between these effects. Twelve men received a high‐protein diet for 15 days and at another time a high‐carbohydrate diet also for 15 days. Cimetidine, 800 mg daily at bedtime, was administered on days 10 through 15 of each dietary period. Theophylline metabolism was studied after the administration of a single intravenous 3 mg/kg dose on days 8 and 15 of each dietary period.

Sanjiv Chopra – 1 May 1991