Marion Peters, John Vierling, M. Eric Gershwin, David Milich, Francis V. Chisari, Jay H. Hoofnagle – 1 May 1991

Christophe Gaudin, Alain Braillon, Jorge Luis Poo, Gerhard Kleber, Richard Moreau, Didier Lebrec – 1 May 1991 – During a hemodynamic study, plasma catecholamine concentrations were measured in the pulmonary artery and in the hepatic vein in 18 presinusoidal portal hypertensive patients. Results were compared with those in 15 nonportal hypertensive subjects and in 24 cirrhotic patients in good condition (grade A, according to Pugh's classification).

Tohru Kimura, Fuminori Moriyasu, Toshihiko Kawasaki, Hitoshi Someda, Takashi Tamada, Yukitaka Yamashita, Shigeki Ono, Kouzou Kajimura, Osamu Nishida, Minoru Okuma – 1 May 1991 – The relationship between esophageal varices and the azygos vein, which is generally considered to drain the major part of the variceal blood flow, was evaluated by percutaneous transhepatic cineportography in 35 patients with portal hypertension. We classified the patients into three groups.

Steven Schenker, Willis C. Maddrey – 1 May 1991

1 May 1991

G. Garcia‐Tsao – 1 May 1991 – Repeated large‐volume paracentesis (4–6 L/day) is an effective and safe therapy of ascites in patients with cirrhosis provided albumin is infused intravenously. To investigate whether ascites can be safely mobilized in only one paracentesis session (“total paracentesis”), 38 cirrhotic patients with tense ascites were treated with total paracentesis plus intravenous albumin (6–8 g/L ascites removed).

Joji Haratake, Masanori Hisaoka, Osamu Yamamoto, Akio Horie – 1 May 1991 – Morphological changes of hepatic microcirculation, especially peribiliary plexus, in experimental rat cirrhosis that resulted from the repeated intraperitoneal injections of N‐diethylnitrosamine, 100 mg/kg body weight/one shot/week, were examined by scanning electron microscope. Control rats were treated with saline. Whole blood vessels of the rats were perfused by saline and stuffed with methylmethacrylated resin.

Eugenia Lamas, Frédérique Zindy, Danielle Seurin, Christiane Guguen‐Guillouzo, Christian Brechot – 1 May 1991 – Insulin‐like growth factor II is believed to play an important role in fetal growth and development. The insulin‐like growth factor II gene expression is tissue specific and developmentally regulated. We have previously shown an enhanced level of insulin‐like growth factor II messenger RNA and protein in human hepatocellular carcinomas. This led to the suggestion that hepatocytes might be involved in insulin‐like growth factor II expression.

Shujiro Takase, Nobuo Takada, Nobuyuki Enomoto, Minoru Yasuhara, Aicira Takada – 1 May 1991 – To verify the existence of chronic hepatitis induced by alcohol, the clinicopathological features of chronic hepatitis in heavy drinkers were studied using various viral markers. Histological features of chronic active hepatitis were seen in 27 heavy drinkers. These patients were divided into four groups.

Daniel R. Ciocca, Arturo D. Jorge, Oliver Jorge, Carlos Milutín, Roberto Hosokawa, Marcelo Díaz Lestren, Estela Muzzio, Sergio Schulkin, Ricardo Schirbu – 1 May 1991 – It has been proposed that in the human liver, the estrogen receptor gene may become inappropriately expressed as a consequence of HBV integration, contributing to cell transformation.