Damrong Ratanasavanh, Philippe Beaune, Fabrice Morel, Jean‐Pierre Flinois, F. Peter Guengerich, Andre Guillouzo – 1 June 1991 – We have used immunohistochemical, immunoblotting and messenger RNA blotting approaches to study the distribution and quantitation of three cytochrome P‐450 enzymes, namely P‐450 IA2, P‐450 IIC and P‐450 IIIA and, for comparison, epoxide hydrolase and NADPH‐cytochrome P‐450 reductase in human liver.

Mercedes Ruiz‐Moreno, Maria José Rua, Josefina Molina, Gloria Moraleda, Alberto Moreno, Jaime García‐aguado, Vicente Carréño – 1 June 1991 – Thirty‐six children with chronic hepatitis B were entered into a randomized controlled trial of recombinant human interferon‐α All patients had hepatitis B virus DNA and increased levels of aminotransferases in serum for at least 1 yr. Twelve children received 10 MU of interferon‐α 2b/m2 body surface area three times a week (group I); 12 children received 5 MU/m2 under the same conditions (group II); and 12 children served as controls (group III).

Domenico Alvaro, Mario Angelico, Alfredo Cantafora, Eugenio Gaudio, Claudia Gandin, Maria Teresa Santini, Roberta Masella, Livo Capocaccia – 1 June 1991 – The intravenous administration of dimethylethanolamine in the rat promotes a selective enrichment of liver membranes with polyunsaturated phosphatidylcholines. The effect of dimethylethanolamine pretreatment on cholestasis induced by estradiol 17β‐D‐glucuronide, a potent cholestatic agent, was assessed in this study. Dimethylethanolamine, dissolved in sodium‐taurocholate was infused intravenously (0.3 mg/kg/min) for 15 hr.

Corinne Vons, Jean‐Paul Pegorier, Jean Girard, Claude Kohl, Marie‐Agnès Ivanov, Dominique Franco – 1 June 1991 – The effects of pancreatic hormones and cyclic AMP on long‐chain fatty‐acid metabolism were investigated in human hepatocytes isolated from 12 liver biopsy specimens and cultured for 4 days in an insulin‐free medium. Glucagon (10−6 mol/L) increased endogenous ketone body production by 150%. This resulted from alterations in the partition of long‐chain fatty acids from esterification toward oxidation.

Sanjiv Chopra – 1 May 1991

Karl E. Anderson, Reneé B. McCleery, Elliot S. Vesell, Florence F. Vickers, Attallah Kappas – 1 May 1991 – This study compared the effects of diet and cimetidine on theophylline metabolism and examined interactions between these effects. Twelve men received a high‐protein diet for 15 days and at another time a high‐carbohydrate diet also for 15 days. Cimetidine, 800 mg daily at bedtime, was administered on days 10 through 15 of each dietary period. Theophylline metabolism was studied after the administration of a single intravenous 3 mg/kg dose on days 8 and 15 of each dietary period.

Robert G. Paul, Stanford T. Roodman, Carolyn R. Campbell, Carol J. Bodicky, Robert P. Perrillo – 1 May 1991 – HLA class I antigen expression on peripheral blood mononuclear cells was evaluated by flow cytometry in 21 HBeAg‐positive patients with chronic hepatitis B. Measurements were made before, during or after treatment with recombinant interferon‐α‐2b, either given alone or after a 6 wk course of prednisone.

Raymond S. Koff – 1 May 1991

Shou‐Dong Lee, Cho‐Yu Chan, Yan‐Jenn Wang, Jaw‐Ching Wu, Kwok‐Hung Lai, Yang‐Te Tsai, Kwang‐Juei Lo – 1 May 1991 – The prevalence of antibody to hepatitis C virus among Chinese subjects in Taiwan was evaluated using a commercially available enzyme immunoassay. The overall prevalence of antibody to hepatitis C virus was 0.28% among 1,419 healthy subjects, 0.8% among 500 unselected paid blood donors and 0.4% among 793 pregnant women.

Riccardo Volpes, Joost J. van den Oord, Valeer J. Desmet – 1 May 1991 – T cells can be divided into two main phenotypic subpopulations–i.e., the CD45RA‐positive (2H4‐positive) “naive” subset and the CD45RO‐positive (UCHL1‐positive) “memory” subset.