Herbert L. Bonkovsky – 1 May 1991 – Twelve forms of human hepatic cytochrome P‐450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P‐450's were analyzed for their abilities to activate the potent hepatocarcinogens aflatoxin B1 to metabolites having mutagenic or DNA‐binding properties. Five forms, P‐450's IA2, IIÁ3, IIB7, IIIA3, and IIIA4, activated aflatoxin B1 to mutagenic metabolites as assessed by the production of His revertants of Salmonella typhimurium in the Ames test.

Michael O. Blackstone – 1 May 1991 – In a prospective study of the natural history of congestive gastropathy, 212 consecutive cirrhotic patients (75 treated with sclerotherapy) were included. Mean follow‐up was 46 months. Mild gastropathy (mosaiclike pattern) was found in 110 patients and severe gastropathy (granular mucosa with cherry spots) was found in 20. Prevalence of Helicobacter pylori, formerly Campylobacter pylori, was 50% in patients without, 43% in those with mild, and 28% in those with severe gastropathy.

Harold O. Conn, Norman D. Grace, Jaime Bosch, Roberto J. Groszmann, Joan Rodés, Steven C. Wright, Daniel S. Matloff, Guadalupe Garcia‐Tsao, Rosemarie L. Fisher, Miguel Navasa, Steven J. Drewniak, Colin E. Atterbury, Jose M. Bordas, Emanuel Lerner, Christina Bramante – 1 May 1991 – To assess the effectiveness of propranolol in the prevention of initial variceal hemorrhage, a doubleblind, randomized trial was carried out in three centers.

Jean‐Yves Scoazec, Claude Degott, Nicole Brousse, Janine Barge, Georges Molas, François Potet, Jean‐Pierre Benhamou – 1 May 1991 – We report the diagnostic, prognostic and therapeutic features of non‐Hodgkin's lymphoma in eight patients in whom the disease was seen as a primary tumor of the liver.

Susan M. Cole, Eric J. Gowans, Thomas B. Macnaughton, Pauline De La M. Hall, Christopher J. Burrell – 1 May 1991 – It has been postulated that hepatocyte injury resulting from infection with hepatitis D virus may be caused by a direct virus cytotoxicity in contrast to immune‐mediated injury associated with hepatitis B virus. We have transfected HeLa and HepG2 continuous cell lines with a recombinant plasmid containing the hepatitis D antigen gene under the inducible control of the human metallothionein promoter.

1 May 1991

Danilo D. Lasic, Siegfried Walker, Christian J. Bode, K.‐J. Paquet – 1 May 1991

Daniel P. O'Leary, Francis E. Murray, Bradley S. Turner, J. Thomas Lamont – 1 May 1991 – Alterations in the composition of bile during cholesterol gallstone formation appear to be responsible for increased release of gallbladder mucin, a potent cholesterol nucleating agent. We investigated the effects of bile salts on release of radiolabeled glycoproteins by explants of guinea pig gallbladder in organ culture.

Pauline de la M. Hall, John L. Plummer, Anthony H. Ilsley, Michael J. Cousins – 1 May 1991 – Rats were exposed to carbon tetrachloride vapor, 5 days/wk, 6 hr/day, for periods of 5 or 10 wk at a concentration that by itself caused only fatty change with minimal liver cell necrosis and no fibrosis. The same carbon tetrachloride exposure when given in association with chronic alcohol feeding resulted in extensive hepatic fibrosis at 5 wk and established micronodular cirrhosis at 10 wk.

Jorge J. Gumucio, Michael C. Kew – 1 April 1991 – To determine serum thyroxine‐binding globulin (TBG) levels, we used radioimmunoassay, and compared the results obtained with other tests in 231 patients with chronic hepatitis B virus infection to evaluate its clinical implications. All of these patients were hepatitis B surface antigen (HBsAg)‐positive.