Y. Edward Hsia – 1 February 1990 – Genetic disorders were identified infrequently among children presenting with Reye's syndrome in the past. During a two‐year period, we evaluated four consecutive patients referred for intensive care of Reye's syndrome. A standard investigation for inborn errors of metabolism revealed that two patients had enzymatic defects of fatty acid oxidation, and the other two had partial deficiencies of ornithine transcarbamoylase. None had experienced a previous episode of Reye's syndrome, and three of the four had been entirely healthy in the past.

Michael C. Kew, Ernest Song, Abdullah Mohammed, John Hodkinson – 1 February 1990 – The role of contraceptive steroids in the etiology or pathogenesis of hepatocellular carcinoma in urban South African black women was investigated in a hospital‐based case and control study. Participating were 46 women, 19 to 54 yr old, with carcinoma, and 92 matched controls. South African blacks have a high incidence of hepatocellular carcinoma, and urban black women have used contraceptive steroids fairly widely for a number of years.

Wim P. M. Hopman, Jan B. M. J. Jansen, Gerd Rosenbusch, Cornelis B. H. W. Lamers – 1 February 1990 – To determine the role of cholecystokinin and the cholinergic system in intestinal stimulation of gallbladder contraction, we studied the effects of atropine on plasma cholecystokinin and gallbladder contraction in six healthy volunteers (four men and two women aged 20 to 27 yr). Effects were noted after intraduodenal fat instillation and after dosage with exogenous cholecystokinin inducing plasma cholecystokinin concentrations similar to those after intraduodenal fat instillation.

Toshiaki Nakashima, Atsushi Sano, Yoshifumi Seto, Toshikazu Nakajima, Toshihide Shima, Yoshikuni Sakamoto, Tadao Okuno, Kei Kashima, Takeshi Hasegawa – 1 February 1990 – Urinary bile acids from 20 patients treated with chenodeoxycholate, 18 treated with ursodeoxycholate, 15 treated with rifampicin and 8 patients with advanced cirrhosis were analyzed by gas‐liquid chromatography and gas‐liquid chromatography‐mass spectrometry.

1 February 1990

Claudio Tiribellp, J. Donald Ostrow – 1 February 1990

Leroy Shear – 1 February 1990 – Fifty‐seven cirrhotic patients with intractable ascites had a portosystemic shunt. In 35 patients, a peritoneovenous shunt had previously failed. Forty‐six patients were in Pugh's class B and 11 were in class C. There were three operative deaths (5.3%). Fifty‐three (98.2%) of the 54 survivors were cleared of ascites. In one patient, ascites persisted because of postshunt heart failure that resulted in a marked increase of caval pressure. Twenty‐seven patients (50%) had late encephalopathy, which was severe and disabling in 12 (22%).

Philippe Roingeard, Shilun Lu, Camille Sureau, Marianne Freschlin, Brigi, Max Essex, Jean‐Loup Romet‐Lemonne – 1 February 1990 – The relationship between the presence of hepatitis B virus antigens, their localization and hepatitis B virus replication was studied in different clones of cultured HepG2 hepatoblastoma cells transfected with cloned hepatitis B virus DNA. Intracellular hepatitis B virus antigens were detected by immunofluorescence. The production of these antigens was evaluated in the culture media by enzyme‐linked immunoassay.

Joan Carles Garcia‐Pagan, Miquel Navasa, Jaime Bosch, Conxita Bru, Pilar Pizcueta, Joan Rodes – 1 February 1990 – This study investigated whether oral doses of isosorbide‐5‐mononitrate, a preferential venous dilator that decreases portal pressure, could enhance the effects of propranolol on portal hypertension. Taking part in the stuty were 28 patients with cirrhosis and portal hypertension.

Elie Serge Zafrani – 1 February 1990 – A patient with acute myeloblastic leukaemia developed jaundice revealing peliosis hepatis after receiving 6‐thioguanine for two months. Peliosis hepatis was severe and was associated with mild lesions of centrilobular veins. Withdrawal of 6‐thioguanine was followed by a progressive improvement of liver dysfunction. This report shows that 6‐thioguanine, a thiopurine already reported to be responsible for veno‐occlusive disease of the liver, can induce peliosis hepatis.