Energy metabolism in patients with acute and chronic liver disease

Bruno Schneeweiss, Wolfgang Graninger, Peter Ferenci, Sabine Eichinger, Georg Grimm, Barbara Schneider, Anton N. Laggner, Kurt Lenz, Gunter Kleinberger – 1 March 1990 – Energy expenditure and substrate oxidation rate for fat, glucose and protein were evaluated by indirect calorimetry in 20 normal individuals, 35 patients with acute hepatitis and 22 patients with biopsyproven alcoholic cirrhosis in the postabsorptive state. Measurements were done in the resting state after an overnight fast (10 to 12 hr).

Amoxicillin‐clavulanic acid therapy of spontaneous bacterial peritonitis: A prospective study of twenty‐seven cases in cirrhotic patients

Jean D. Grange, Xavier Amiot, Veronique Grange, Laurent Gutmann, Michel Biour, François Bodin, Raoul Poupon – 1 March 1990 – Spontaneous bacterial peritonitis in cirrhosis is a serious complication that demands urgent attention. We report here a prospective study of the treatment of 27 episodes of spontaneous bacterial peritonitis in 22 cirrhotic patients with amoxicillin and clavulanic acid. The infection of ascitic fluid was diagnosed by a positive culture plus an ascitic neutrophil count exceeding 75/μl, or by an ascitic neutrophil count exceeding 500/μl.

Hepatic mycobacterial disease and aids

Richard W. Light – 1 March 1990 – We reviewed the clinical data, hepatic histology, and microbiological features of 21 patients with previously documented acquired immune deficiency syndrome who had liver biopsies. Diagnoses of specific infections were made on liver biopsy in 11/21 patients (57%). Granulomas were found in 10/21 patients (48%) and were most often a manifestation of infection with Mycobacterium avium‐intracellulare.

The hepatocyte protein synthesis defect induced by galactosamine involves hypomethylation of ribosomal RNA

Gary A. Clawson, Julie Sesno, Kathy Milam, Yan‐Fel Wang, Caroline Gabriel – 1 March 1990 – D‐galactosamine produces an early defect in protein synthesis, independent of its effects on RNA synthcsis. Here we show that the defect in protein synthesis is inherent in purified ribosomal subunits in vitro.

Antibodies against the hepatic asialoglycoprotein receptor perfused In Situ preferentially attach to periportal liver cells in the rat

Barbara M. McFarlane, Jozsef Sipos, Christopher D. Gove, Ian G. McFarlane, Roger Williams – 1 March 1990 – Autoantibodies reacting with the galactose‐specific hepatic asialoglycoprotein receptor—a liver‐specific component expressed on the surfaces of hepatocytes—are often found in patients with chronic active hepatitis of presumed autoimmune origin.

Recurrence factors studied by percutaneous transpepatic portography before and after endoscopic sclerotherapy for esophageal varies

Yasuhiro Takase, Susumu Shibuya, Fumio Chikamori, Kazuo Orii, Yoji Iwasaki – 1 March 1990 – High recurrence and rebleding rates have been reported when endocopic sclerotherapy has been performed on patients with esophageal varices. We studied the relationship between embolization range and recurrence rate in 26 patients in whom percutaneous transhepatic portography was carried out before and after sclerotherapy. Patients were divided into complete and incomplete embolization groups. The complete and incomplete embolization groups.

Spontaneous bacterial empyema in cirrhotic patients: Analysis of eleven cases

Xavier Xiol, Jose Castellote, Carme Baliellas, Javier Ariza, Ana Gimenez Roca, Jordi Guardiola, Luis Casais – 1 March 1990 – Eleven episodes of spontaneous bacterial empyema were identified in eight cirrhotic patients with ascites. Criteria for spontaneous bacterial empyema included positive pleural fluid culture or polymorphonuclear cell concentration >500 cells/mm3, evidence of pleural effusion before an infectious episode and transudate characteristics during infection.

Plasma des‐γ‐carboxyprothrombin in the early stage of hepatocellular carcinoma

Sun‐Lung Tsai, Guan‐Tarn Huang, Pei‐Ming Yang, Jin‐Chuan Sheu, Juei‐Low Sung, Ding‐Shinn Chen – 1 March 1990 – To evaluate the role of plasma des‐γ‐carboxyprothrombin in the early diagnosis of hepatocellular carcinoma, we simultaneously studied both des‐γ‐carboxyprothrombin activities by staphylocoagulase method and des‐γ‐carboxyprothrombin antigen levels by enzyme immunoassay in 39 patients with early stage hepatocellular carcinoma (tumor size <3 cm in 21 patients, 3 to 5 cm in 18 patients); 68 patients had large hepatocellular carcinoma and 54 patients had chronic hepatitis or cirrhosi

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