MHC antigen expression in human liver grafts: Its role in rejection

Dale C. Snover – 1 April 1990 – The present study documents major histocompatibility complex (MHC) Class I and II expression during early acute rejection of human liver grafts. Serial graft biopsies (pretransplant, time zero, and 1 week) were studied. Ten patients received azathioprine (AZA) and prednisone; the other six patients were treated with quadruple therapy (azathioprine, cyclosporine A, prednisone, and cyclophosphamide). To study the specificity of changes in MHC antigen expression, biopsies of six patients with minor or no morphologic abnormalities served as controls.

Autoantibodies to isolated human hepatocyte plasma membranes in chronic active hepatitis. II. Specificity of antibodies

Nigel R. Swanson, William D. Reed, Linda J. Yarred, Keith B. Shilkin, Richard A. Joske – 1 April 1990 – The fine specificity of autoantibodies to human hepatocyte plasma membranes in autoimmune chronic active hepatitis was determined by one‐dimensional immunoblotting. Sera from 12 patients with “classical” autoimmune chronic active hepatitis contained autoantibodies recognizing many human hepatocyte plasma membrane polypeptides in the 15 to 220 kD range.

Excessive in vitro bacterial lipopolysaccharide‐induced production of monokines in cirrhosis

Jacques Devière, Jean Content, Chantal Denys, Paul Vandenbussche, Liliane Schandene, Joseph Wybran, Etienne Dupont – 1 April 1990 – The objective of this study was to analyze monokine production by peripheral blood mononuclear cells from patients with alcoholic cirrhosis. The capacity of peripheral blood mononuclear cells and purified monocytes from these patients to produce tumor necrosis factor α, interleukin 1β, and interleukin 6 was investigated.

Anesthesia and pressor responsiveness in chronic bile‐duct‐ligated dogs

Arieh Bomzon, Irka Monies‐Chass, Leonard Kamenetz, Laurence Blendis – 1 April 1990 – Cardiovascular homeostasis is compromised under general anesthesia and in jaundice. Because surgery is often performed on jaundiced patients, it is not altogether surprising that the incidence of perioperative complications is higher in such patients than in nonjaundiced ones. In this study we assessed the potential synergistic effects of anesthesia and jaundice on cardiovascular responsiveness of chronic bile‐ductligated dogs.

Isolation of a potent cholesterol nucleation‐promoting activity from human gallbladder bile: Role in the pathogenesis of gallstone disease

Albert K. Groen, Christa Noordam, Jan A. G. Drapers, Peter Egbers, Peter L. M. Jansen, Guido N. J. Tytgat – 1 April 1990 – Gallbladder bile contains nucleation‐promoting activity that binds to concanavalin A. The activity was found in gallbladder bile from cholesterol gallstone patients but also in gallbladder bile from patients without stones and patients with pigment stones. Bile from patients with multiple cholesterol gallstones contained high concanavalin A‐binding nucleation‐promoting activity.

Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: An analysis by tissue distribution, purification and N‐terminal amino acid sequence

Geoffrey W. McCaughan, Julie E. Wickson, Paul F. Creswick, Mark D. Gorrell – 1 April 1990 – This paper describes the tissue distribution, purification and N‐terminal amino acid sequence of the bile canalicular cell surface molecule dipeptidyl peptidase IV. Immunoperoxidase staining of cryostat sections of rat liver with a monoclonal antibody, Medical Research Council OX‐61, indicated specific binding to hepatocyte bile canalicular domains and brush borders of bile ducts.

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