Increased densities of peripheral‐type benzodiazepine receptors in brain autopsy samples from cirrhotic patients with hepatic encephalopathy

Joel Lavoie, Gilles Pomier Layrargues, Roger F. Butterworth – 1 May 1990 – Peripheral‐type benzodiazepine receptors were evaluated using the specific ligand [3H]‐PK 11195 in brain homogenates from nine cirrhotic patients who died in hepatic coma and from an equal number of age‐matched control subjects. Histopathological studies showed evidence of severe Alzheimer type II astrocytosis in the brains of all cirrhotic patients. Saturation‐binding assays revealed a single saturable binding site for [3H]‐PK 11195 in brain, with affinities in the 2‐ to 3‐nmol/L range.

Fate of Mallory body‐containing hepatocytes: Disappearance of Mallory bodies and restoration of the hepatocytic intermediate filament cytoskeleton after drug withdrawal in the griseofulvin‐treated mouse

Kurt Zatloukal, Gerlinde Spurej, Ingrid Rainer, Elisabeth Lackinger, Helmut Denk – 1 April 1990 – Mallory bodies are characteristic morphological features of alcoholic hepatitis in man and can be produced in the mouse by chronic griseofulvin intoxication. The appearance of Mallory bodies in hepatocytes is associated with derangement of the cytokeratin intermediate filament cytoskeleton, at least as revealed by immunofluorescence and suggested by immunoelectron microscopy.

MHC antigen expression in human liver grafts: Its role in rejection

Dale C. Snover – 1 April 1990 – The present study documents major histocompatibility complex (MHC) Class I and II expression during early acute rejection of human liver grafts. Serial graft biopsies (pretransplant, time zero, and 1 week) were studied. Ten patients received azathioprine (AZA) and prednisone; the other six patients were treated with quadruple therapy (azathioprine, cyclosporine A, prednisone, and cyclophosphamide). To study the specificity of changes in MHC antigen expression, biopsies of six patients with minor or no morphologic abnormalities served as controls.

Autoantibodies to isolated human hepatocyte plasma membranes in chronic active hepatitis. II. Specificity of antibodies

Nigel R. Swanson, William D. Reed, Linda J. Yarred, Keith B. Shilkin, Richard A. Joske – 1 April 1990 – The fine specificity of autoantibodies to human hepatocyte plasma membranes in autoimmune chronic active hepatitis was determined by one‐dimensional immunoblotting. Sera from 12 patients with “classical” autoimmune chronic active hepatitis contained autoantibodies recognizing many human hepatocyte plasma membrane polypeptides in the 15 to 220 kD range.

Excessive in vitro bacterial lipopolysaccharide‐induced production of monokines in cirrhosis

Jacques Devière, Jean Content, Chantal Denys, Paul Vandenbussche, Liliane Schandene, Joseph Wybran, Etienne Dupont – 1 April 1990 – The objective of this study was to analyze monokine production by peripheral blood mononuclear cells from patients with alcoholic cirrhosis. The capacity of peripheral blood mononuclear cells and purified monocytes from these patients to produce tumor necrosis factor α, interleukin 1β, and interleukin 6 was investigated.

Anesthesia and pressor responsiveness in chronic bile‐duct‐ligated dogs

Arieh Bomzon, Irka Monies‐Chass, Leonard Kamenetz, Laurence Blendis – 1 April 1990 – Cardiovascular homeostasis is compromised under general anesthesia and in jaundice. Because surgery is often performed on jaundiced patients, it is not altogether surprising that the incidence of perioperative complications is higher in such patients than in nonjaundiced ones. In this study we assessed the potential synergistic effects of anesthesia and jaundice on cardiovascular responsiveness of chronic bile‐ductligated dogs.

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