Malcolm M. Berenson, Cathy Gunther, Wade S. Samowitz, David J. Bjorkman – 1 May 1990 – The effect of bile acids on the formation of biliary thrombi in protoporphyrin‐induced cholestasis was determined by perfusing isolated rat livers with taurocholate, chenodeoxycholate and ursodeoxycholate with and without protoporphyrin. Protoporphyrin‐induced reduction of bile flow was similar in the presence of each bile acid.

Hajime Takikawa, Naoyo Sano, Tohru Narita, Masami Yamanaka – 1 May 1990 – The reason for the discrepancy between bile flow and biliary bile acid excretion during ursodeoxycholate infusion in rats is unknown. We found that ursodeoxycholate‐glucuronide is formed during ursodeoxycholate infusion at higher doses. Ursodeoxycholate infusion (1 to 3 μmol/min/100 gm body weight) for 90 min caused marked hypercholeresis, and the previously reported discrepancy between bile flow and biliary bile acid excretion was observed when bile acid concentrations were measured by regular enzymatic methods.

Christopher Babbs, Najib Y. Haboubi, Jonathan M. Mellor, Alexander Smith, Brenda P. Rowan, Thomas W. Warnes – 1 May 1990 – There is increasing interest in the changes of the endothelial lining of the hepatic sinusoids during the development of chronic liver disease. In this study we looked for evidence of hepatic sinusoidal endothelial cell transformation and basement membrane production in patients with primary biliary cirrhosis.

E. Anthony Jones, Nora V. Bergasa – 1 May 1990

Adrian M. Di Bisceglie, Kamal G. Ishak, Lionel Rabin, Jeffrey M. Hoeg – 1 May 1990 – We describe three patients with cholesteryl ester storage disease. Diagnosis was confirmed by demonstrating a deficiency in lysosomal acid cholesteryl hydrolase activity in cultured skin fibroblasts from each of these patients. All had hepatomegaly, elevated serum aminotransferase activities and hyperlipoproteinemia. Histological examination of liver biopsy specimens before treatment revealed accumulation of fat within hepatocytes, bile duct epithelium and endothelial and Kupffer cells.

Robert Goldin, John Saldanha, Howard Thomas, Stanislas Pol, Pierre Berthelot, Frederic Dubois – 1 May 1990

Chaitanya R. Divgi, Alfred M. Cohen – 1 May 1990 – We have established a large library of monoclonal antibodies against a human hepatoma cell line called FOCUS. One such monoclonal antibody (SF‐25) detects a 125‐kilodalton cell surface antigen found on FOCUS cells. As both the liver and the colon are of endodermal origin, we examined the possibility of expression in colon adenocarcinomas. This antigen was found in all 23 colon adenocarcinoma tissues surgically obtained but was absent in the adjacent normal mucosal counterpart as determined by a direct radioimmunohistologic technique.

Veerapol Kukongviriyapan, Neill H. Stacey – 1 May 1990 – Isolated rat hepatocytes have been advocated as a model to study aspects of mechanism of chemicalinduced interference with biliary excretory function. Some technical problems do exist in studying efflux, such as the reuptake of the previously excreted substrate. Another concern is the loss of liver‐specific functions in hepatocytes with continuing time in culture. It is important to address such technical aspects and to determine whether the process of efflux is compromised in primary cultures of hepatocytes.

Christopher C. Baker – 1 May 1990 – To further define the computed tomographic (CT) criteria on which to guide the nonsurgical treatment of adult patients with blunt hepatic injury, the authors retrospectively reviewed abdominal CT scans obtained before surgery during a 35‐month period. Blunt hepatic injury was diagnosed in 187 patients, and review revealed 37 patients in whom the liver was the site of sole or principal intraabdominal injury detected with the help of CT before surgery.

1 May 1990