Paul J. Cote, Christoph Pohl, Juanell Boyd, Bud C. Tennant, John L. Gerin – 1 May 1990 – Woodchuck hepatitis virus infection of the eastern woodchuck represents a useful model for the study of hepatitis B virus infection and disease in humans, including hepatocellular carcinoma. In man, hepatocellular carcinoma is frequently detected and monitored using assays for serum alpha‐fetoprotein.

Epaminondas V. Tsianos, Jay H. Hoofnagle, Philip C. Fox, Margaret Alspaugh, E. Anthony Jones, Daniel F. Schafer, Haralampos M. Moutsopoulos – 1 May 1990 – Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%).

Brent Tetri, Mary J. Ruwart, Karen F. Wilkinson, Bob D. Rush, Thomas J. Vidmar, Kenneth M. Peters, Keith S. Henley, Henry D. Appelman, Detlef Schuppan – 1 May 1990

Marie‐Anne Petit, Fabien Zoulim, Francis Caipel, Sylvie Dubanchet, Charles Dauguet, Christina Trepo – 1 May 1990 – The expression of the preSl antigen of hepatitis B virus in sera from chronic HBsAg carriers was studied using a specific monoclonal antibody F35.25 in an original, double‐immunoradiometric assay. The antibody F35.25 recognized an epitope located between amino‐acid residues 32 and 53 on the preSl sequence of the large HBsAg protein. This domain could be involved in the recognition of hepatitis B virus by hepatocyte receptors.

Ian R. Wanless – 1 May 1990 – Nodular regenerative hyperplasia is defined by he‐patocellular nodules distributed throughout the liver in the absence of fibrous septa between the nodules. Most reports have been single cases so that the prevalencend clinical significance of nodular regenerative hyperplasia is uncertain. In this study, the hepatic histology of 2,500 consecutive autopsies was reviewed.

Georg Wensing, Robert A. Branch – 1 May 1990 – The onset of sodium retention in phenobarbital/carbon tetrachloride‐induced cirrhosis in rats is preceded by a linear decrease in hepatic function as assessed by the aminopyrine rate constant of elimination. Sodium retention occurs when liver function decreases below a critical aminopyrine rate constant of elimination threshold of 1 min− × 10−3.

1 May 1990

Serge Erlinger – 1 May 1990

H. Dariush Fahimi, Alfred Voelkl, Styliani H. Vincent, Ursula Muller‐Eberhard – 1 May 1990 – The abundant heme‐binding protein of the liver, probably identical with Z‐protein or liver fatty acid‐binding protein, has an apparent molecular weight of 14,000 Da and is presumably involved in the intracellular transport of a variety of compounds. The cellular and subcellular distribution of HBP in the liver was studied in adult male and female rats by postembedding immunocytochemistry using the protein A‐gold technique.

Jen‐Hwey Chiu, Cheng‐Po Hu, Wing‐Yiu Lui, Szecheng J. Lo, Chungming Chang – 1 May 1990 – Hepatocytes, known as polarized epithelial cells, are composed of sinusoid, basolateral and bile canalicular domains. Each domain contains proteins specific for it. Our studies indicate that the well‐differentiated human hepatoma cell lines HepG2 and HuH‐7 formed bile canaliculi in tissue culture, whereas the poorly differentiated hepatoma cell lines HA22T/VGH and SK‐HEP‐1 did not.