Craig A. Robertson, Ross L. Coppel, Thomas Prindiville, David Fregeau, Marshall Kaplan, E. Rolland Dickson, M. Eric Gershwin – 1 May 1990 – In normal individuals there is an adaptive immune response to a foreign antigen in which antibodies of increasing affinity are produced with time. This is not always true of an autoimmune response. However, because only a limited number of autoantigens have been cloned or purified, this issue has not been studied well.

Edward Cheuck‐Seen Lai, Irene Oi‐Lin Ng, Mathew Ma‐Tai Ng, Anna Shuk‐Fong Lok, Po‐Chor Tam, Sheung‐Tat Fan, Tat‐Kuen Cho, John Wong – 1 May 1990 – Recurrent or metastatic disease is frequently en‐countered among patients who have had resection of their primary hepatocellular carcinoma. A retro‐spective study on 117 patients (104 men, 13 women; mean age ± standard deviation: 53.8 ± 12.4 yr) who had hepatectomy for large hepatocellular carcinoma (diameter ≧ 5 cm) was conducted to identify an at‐risk population for tumor recurrence.

Paaul C. Adams, Luan A. Chau – 1 May 1990 – The effect of hepatic iron on the uptake of ferritin was studied by perfusing livers from normal, iron deficient and iron‐loaded rats with 125I‐labeled ferritin. Unlabeled ferritin with tracer doses of labeled ferritin in concentrations of 0.02 to 2,700 nmol/L were studied. Rats were made iron deficient by feeding an established iron‐deficient diet for 3 wk. Rats were iron loaded by injection of iron dextran (50 mg/wk) for 3 wk.

John J. Lemasters, Anna‐Liisa Nieminen, Brian Herman – 1 May 1990

Irwin M. Arias – 1 May 1990

Norman Gitlin – 1 May 1990 – The aim of this retrospective study was to define prognostic factors for cure and survival after spontaneous bacterial peritonitis. In a 4‐year period from 1982 to 1986, spontaneous bacterial peritonitis wasdiagnosed in 38 consecutive hospitalized cirrhotic patients (positive ascites culture and polymorphonuclear cell concentrations greater than 250 cells per mm3). Twenty‐five patients recovered from their infection (69 p. 100) in a mean time of 9 ± 7 days. The cumulative survival was 68 p. 100 at one week, 50 p. 100 at one month, and 25 p. 100 at one year.

Paul J. Cote, Christoph Pohl, Juanell Boyd, Bud C. Tennant, John L. Gerin – 1 May 1990 – Woodchuck hepatitis virus infection of the eastern woodchuck represents a useful model for the study of hepatitis B virus infection and disease in humans, including hepatocellular carcinoma. In man, hepatocellular carcinoma is frequently detected and monitored using assays for serum alpha‐fetoprotein.

Epaminondas V. Tsianos, Jay H. Hoofnagle, Philip C. Fox, Margaret Alspaugh, E. Anthony Jones, Daniel F. Schafer, Haralampos M. Moutsopoulos – 1 May 1990 – Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%).

Brent Tetri, Mary J. Ruwart, Karen F. Wilkinson, Bob D. Rush, Thomas J. Vidmar, Kenneth M. Peters, Keith S. Henley, Henry D. Appelman, Detlef Schuppan – 1 May 1990

Marie‐Anne Petit, Fabien Zoulim, Francis Caipel, Sylvie Dubanchet, Charles Dauguet, Christina Trepo – 1 May 1990 – The expression of the preSl antigen of hepatitis B virus in sera from chronic HBsAg carriers was studied using a specific monoclonal antibody F35.25 in an original, double‐immunoradiometric assay. The antibody F35.25 recognized an epitope located between amino‐acid residues 32 and 53 on the preSl sequence of the large HBsAg protein. This domain could be involved in the recognition of hepatitis B virus by hepatocyte receptors.