Tadashi Terada, Yasuni Nakanuma – 1 July 1990 – It remains unclear whether atypical epithelial lesions, including carcinomas and precancerous lesions, develop in intraheptic peribiliary glands. This question was tested in this study. One thousand livers from consecutive autopsies were surveyed and 201 livers with bile duct carcinomas or metastatic malignant neoplasms were excluded because atypical epithelial lesions of the glands were difficult to distinguish from the primary or metastatic malignant cells.

Riccardo Volpes, Joost J. van den Oord, Valeer J. Desmet – 1 July 1990 – Using monoclonal antibodies and in situ immunohistochemistry, we studied the distribution of “accessory” adhesion molecules (i.e., intercellular adhesion molecule‐1 and leukocyte function–associated antigen‐3) in 114 liver biopsy specimens with various inflammatory liver diseases and in 12 control liver biopsy samples without inflammation.

Irwin M. Arias – 1 July 1990

Patrizia Bagnarelli, Giulia Devescovi, Aldo Manzin, Italo Bearzi, Patrizia Bonazzi, Guido Carloni, Massimo Clementi – 1 June 1990 – The establishment of a new, differentiated, hepatitis B virus DNA‐negative, human hepatoma cell line (named PLC/AN/2) is described. Neoplastic liver tissue was obtained during hepatectomy in an HBsAg‐negative man. The established cell line is negative for α‐fetoprotein and carcinoembryonic antigen; it has retained in vitro some of the differentiated functions of normal hepatocytes.

Philip B. Hylemon, Patricia M. Bohdan, Alphonse E. Sirica, Douglas M. Heuman, Z. Reno Vlahcevic – 1 June 1990 – The role of hepatocytes in bile acid and cholesterol metabolism has been extensively studied. By contrast, nothing is known about the role of bile ductular epithelial cells in cholesterol and bile acid metabolism. The purpose of the current studies was to establish whether bile ductular epithelial cells synthesize cholesterol, bile acids or both and to determine whether these cells are capable of metabolizing (hydroxylating, conjugating) bile acids.

Fredrick L. Weber, Brenda S. Bagby, Lucilla Licate, Steven G. Kelsen – 1 June 1990 – This study was conducted to determine whether an amino acid solution enriched with branched‐chain amino acids altered protein catabolic rates and plasma ammonia in patients with cirrhosis. Nine stable subjects were given two peripheral intravenous infusions: a standard amino acid solution (solution A) and a branched‐chain‐enriched solution containing 97% more leucine (solution B). Each solution was given for separate 9‐day (group 1, n = 6) or 3‐day (group 2, n = 3) periods.

1 June 1990

J. J. Visser, S. Meijer, Kentaro Yoshiko, Donald Cohen, Crig J McCleain – 1 June 1990

Norio Ogata, Takashi Tokino, Tomoteru Kamimura, Hitoshi Asakura – 1 June 1990 – To elucidate critical genetic elements in the development of hepatocellular carcinoma associated with hepatitis B virus DNA integration, a single integrant in hepatocellular carcinoma cells and one species of multiple integrants in hepatocytes, both obtained from the same patient, were compared structurally using molecular cloning techniques. Both hepatitis B virus integrants showed similar inverted repeat sequences consisting of two defective virus genomes.

Josep Teres, Ramon Planas, Julia Panes, Joan Manel Salmeron, Antoni Mas, Jaime Bosch, Covadonga Llorente, Josep Viver, Faust Feu, Joan Rodés – 1 June 1990 – Vasopressin infusion and esophageal tamponade are still widely used to arrest variceal bleeding, but no objective evidence exists on the superiority of either of the two procedures.