Single‐Cell, Single‐Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity

Tallulah S. Andrews, Jawairia Atif, Jeff C. Liu, Catia T. Perciani, Xue‐Zhong Ma, Cornelia Thoeni, Michal Slyper, Gökcen Eraslan, Asa Segerstolpe, Justin Manuel, Sai Chung, Erin Winter, Iulia Cirlan, Nicholas Khuu, Sandra Fischer, Orit Rozenblatt‐Rosen, Aviv Regev, Ian D. McGilvray, Gary D. Bader, Sonya A. MacParland – 17 November 2021 – The critical functions of the human liver are coordinated through the interactions of hepatic parenchymal and non‐parenchymal cells.

Fatty Liver and the Coronavirus Disease 2019 Pandemic: Health Behaviors, Social Factors, and Telemedicine Satisfaction in Vulnerable Populations

Rebecca G. Kim, Sheyla P. Medina, Catherine Magee, Mandana Khalili – 17 November 2021 – The coronavirus disease 2019 (COVID‐19) pandemic has impacted health‐related behaviors that influence fatty liver disease (FLD) management. We evaluated the impact of the pandemic on FLD management and satisfaction with care delivery in this population.

Impact of the Corona Virus Disease 2019 Pandemic on Hepatology Practice and Provider Burnout

Mark W. Russo, Ryan Kwok, Marina Serper, Nneka Ufere, Bilal Hameed, Jaime Chu, Elizabeth Goacher, John Lingerfelt, Norah Terrault, K. Rajender Reddy – 15 November 2021 – The corona virus disease 2019 (COVID‐19) pandemic has had a wide‐ranging impact on the clinical practice of medicine and emotional well‐being of providers. Our aim was to determine the impact of the COVID‐19 pandemic on practice and burnout among hepatology providers.

PSMA as a Theranostic Target in Hepatocellular Carcinoma: Immunohistochemistry and 68Ga‐PSMA‐11 PET Using Cyclotron‐Produced 68Ga

Scott M. Thompson, Garima Suman, Michael S. Torbenson, Zong‐Ming E. Chen, Danielle E. Jondal, Anurima Patra, Eric C. Ehman, James C. Andrews, Chad J. Fleming, Brian T. Welch, Anil N. Kurup, Lewis R. Roberts, Kymberly D. Watt, Mark J. Truty, Sean P. Cleary, Rory L. Smoot, Julie K. Heimbach, Nguyen H. Tran, Amit Mahipal, Jun Yin, Tyler Zemla, Chen Wang, Zachary Fogarty, Mark Jacobson, Bradley J. Kemp, Sudhakar K. Venkatesh, Geoffrey B. Johnson, David A. Woodrum, Ajit H.

Presence of Liver Inflammation in Asian Patients With Chronic Hepatitis B With Normal ALT and Detectable HBV DNA in Absence of Liver Fibrosis

Jiacheng Liu, Jian Wang, Xiaomin Yan, Ruifei Xue, Jie Zhan, Suling Jiang, Yu Geng, Yilin Liu, Minxin Mao, Juan Xia, Shengxia Yin, Xin Tong, Yuxin Chen, Weimao Ding, Rui Huang, Chao Wu – 14 November 2021 – Liver biopsies are recommended to exclude significant liver inflammation in patients with chronic hepatitis B (CHB) with elevated HBV DNA but without other indications for antiviral treatment. We aimed to investigate the proportions and determinants of significant inflammation in Asian patients with CHB with detectable HBV DNA.

An Analysis of Free‐Text Refusals as an Indicator of Readiness to Accept Organ Offers in Liver Transplantation

Jin Ge, Elaine Ku, Garrett R. Roll, Jennifer C. Lai – 14 November 2021 – Racial/ethnic minorities experience higher rates of wait‐list mortality and longer waiting times on the liver transplant wait list. We hypothesized that racial/ethnic minorities may encounter greater logistical barriers to maintaining “readiness” on the wait list, as reflected in offer nonacceptance. We identified all candidates who received an organ offer between 2009 and 2018 and investigated candidates who did not accept an organ offer using a free‐text refusal reason associated with refusal code 801.

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