Coskun Ozer Demirtas, Gabrielle Ricco, Osman Cavit Ozdogan, Feyyaz Baltacioglu, Tunc Ones, Perran Fulden Yumuk, Ender Dulundu, Sinan Uzun, Pierro Colombatto, Filippo Oliveri, Maurizia Rosanna Brunetto, Feyza Gunduz – 8 November 2021 – Optimal scoring system for clinical prognostic factors in patients with unresectable hepatocellular carcinoma (HCC) is currently uncertain. We aimed to develop and externally validate an easy to use tool, particularly for this population, and named it the “unresectable hepatocellular carcinoma prognostic index” (UHPI).

Eric Savier, Chetana Lim, Olivier Scatton – 7 November 2021

Nan Wu, Guido Carpino, Ludovica Ceci, Leonardo Baiocchi, Heather Francis, Lindsey Kennedy, Tianhao Zhou, Lixian Chen, Keisaku Sato, Konstantina Kyritsi, Vik Meadows, Burcin Ekser, Antonio Franchitto, Romina Mancinelli, Paolo Onori, Eugenio Gaudio, Shannon Glaser, Gianfranco Alpini – 6 November 2021

Myrick C. Shinall, Kemberlee Bonnet, David Schlundt, Manisha Verma – 6 November 2021 – Patients undergoing evaluation for liver transplantation face heavy burdens of symptoms, health care use, and mortality. In other similarly ill populations, specialist palliative care has been shown to benefit patients, but specialist palliative care is infrequently used for liver transplantation patients. This project aims to describe the potential benefits of and barriers to specialist palliative care integration in the liver transplantation process.

Adrian Kuipery, Juan Diego Sanchez Vasquez, Aman Mehrotra, Jordan J. Feld, Harry L. A. Janssen, Adam J. Gehring – 6 November 2021

Norah A. Terrault, Abdus S. Wahed, Jordan J. Feld, Stewart L. Cooper, Mark G. Ghany, Mauricio Lisker‐Melman, Robert Perrillo, Richard K. Sterling, Mandana Khalili, Raymond T. Chung, Philip Rosenthal, Robert J. Fontana, Arif Sarowar, Daryl T. Y. Lau, Junyao Wang, Anna S. Lok, Harry L. A. Janssen – 6 November 2021

James M. Paik, Khaled Kabbara, Katherine E. Eberly, Youssef Younossi, Linda Henry, Zobair M. Younossi – 5 November 2021

Quan Chen, Austin Z. Chen, Guorong Jia, Jindian Li, Chuansheng Zheng, Kai Chen – 4 November 2021 – Liver cancer is one of the leading causes of cancer deaths worldwide. Among all primary liver cancers, hepatocellular carcinoma (HCC) is the most common type, representing 75%‐85% of all primary liver cancer cases. Median survival following diagnosis of HCC is approximately 6 to 20 months due to late diagnosis in its course and few effective treatment options. Interventional therapy with minimal invasiveness is recognized as a promising treatment for HCC.

Thomas H. Tranah, Victoria T. Kronsten, Debbie L. Shawcross – 4 November 2021 – Cirrhosis‐associated immune dysfunction (CAID) describes a panacea of innate and adaptive deficits that result from the sequelae of cirrhotic portal hypertension that is similar in its manifestations regardless of etiology of chronic liver injury. CAID is associated with synchronous observations of dysregulated priming of innate immune effector cells that demonstrate a proinflammatory phenotype but are functionally impaired and unable to adequately prevent invading pathogens.

Yetirajam Rajesh, Saranya Chidambaranathan Reghupaty, Rachel G. Mendoza, Debashri Manna, Indranil Banerjee, Mark A. Subler, Korri Weldon, Zhao Lai, Shah Giashuddin, Paul B. Fisher, Arun J. Sanyal, Rebecca K. Martin, Mikhail G. Dozmorov, Jolene J. Windle, Devanand Sarkar – 4 November 2021 – Obesity is an enormous global health problem, and obesity‐induced nonalcoholic steatohepatitis (NASH) is contributing to a rising incidence and mortality for hepatocellular carcinoma (HCC).