Diabetes‐Induced cholestasis in the rat: Possible role of hyperglycemia and hypoinsulinemia

Jose Juan Garcia‐Marin, Gloria R. Villanueva, Alejandro Esteller – 1 March 1988 – In one of our earlier studies, an impaired biliary function in diabetes was suggested. We studied bile formation in rats with streptozotocin‐induced diabetes (60 mg per kg body weight). Diabetic rats showed hyperglycemia and hypoinsulinemia, but no significant changes in hematocrit, plasma protein concentration or plasma osmolality. Bile flow was significantly (p < 0.05) reduced (‐23%) as compared with control animals, despite a higher (p < 0.05) bile acid secretion rate (+56%).

A new variant of type IV glycogenosis: Deficiency of branching enzyme activity without apparent progressive liver disease

Harry L. Greene, Barbara I. Brown, Daniel T. McClenathan, Rocco M. Agostini, Suzanne R. Taylor – 1 March 1988 – Type IV glycogenosis is due to branching enzyme deficiency and is usually manifested clinically by progressive liver disease with cirrhosis and hepatic failure between the second and fourth years of life. We describe a 5‐year‐old boy who, following an acute febrile illness at 2 years of age, was first noted to have hepatomegaly with mildly elevated serum transaminase levels.

Lobular distribution of alcohol dehydrogenase in the rat liver

Masayoshi Yamauchi, James J. Potter, Esteban Mezey – 1 March 1988 – The hepatic lobular localization of alcohol dehydrogenase was determined in male, female and castrated male rats. Alcohol dehydrogenase immunoreactive protein and activity were increased in female and castrated rats as compared to normal male rats. By immunohistochemistry, alcohol dehydrogenase protein was found localized principally in the perivenous area of the hepatic lobule in all of the animals.

Intrahepatic pressure measurement: Not an accurate reflection of portal vein pressure

Daphna Fenyves, Gilles Pomier‐Layrargues, Bernard Willems, Jean Cǒté – 1 March 1988 – Previous studies have established the reliability of percutaneous portal venous pressure measurement using a Chiba needle, a procedure requiring fluoroscopic guidance. Intrahepatic pressure has been advocated by some as a simple and safe index of portal venous pressure. The aim of this study was to examine the reliability of intrahepatic pressure measurement and its relationship to portal venous pressure.

Correspondence

Kevin D. Mullen, Karen M. Szauter, Arthur J. McCullough, Warren D. Lo, David L. McNeely, Steven R. Ennis, Gary W. Goldstein, A. Lorris Betz, J. Michael Henderson, Michael H. Kutner, W. Dean Warren, Josep Terés, Michael S. Myslobodsky, Gül Baktir, Hans U. Fisch, Georg Karlaganis, Christoph Minder, Johannes Bircher – 1 March 1988

The ischemic liver—do not resuscitate too much

Yisrael Isaacson, David H. Van Thiel – 1 March 1988 – The interest in liver transplantation has focused more attention on the mechanisms of injury during hepatic ischemia, preservation, and reperfusion. Although the human liver has been successfully maintained under hypothermic conditions for up to 10 hours, organ preservation remains the major obstacle to liver transplantation.

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