Understanding noncirrhotic portal hypertension: Ménage à FOIS

Ian R. Wanless – 1 January 1988 – Twenty‐six patients with the clinical and histologic diagnosis of primary biliary cirrhosis were reviewed. Nodular hyperplasia of the liver without fibrous rims, not reported hitherto in patients with primary biliary cirrhosis, was found in several patients with early histological stages. These changes resembled “nodular regenerative hyperplasia of the liver” and were usually present as multicellular thickness in zones 1 and 2 of the hepatic lobules.

Hepatic encephalopathy and orotic aciduria associated with hepatocellular carcinoma in a noncirrhotic liver

Lennox J. Jeffers, Richard A. Dubow, Leslie Zieve, K. Rajender Reddy, Alan S. Livingstone, Sidney Neimark, Manuel Viamonte, Eugene R. Schiff – 1 January 1988 – A 40‐yr‐old man presented with encephalopathy and was found to have hepatocellular carcinoma without cirrhosis. A large vascular hepatic mass was defined by CT scan and angiography; laparoscopy with biopsy confirmed the absence of chronic liver disease. A definitive tissue diagnosis of hepatocellular carcinoma was made at laparotomy; the tumor was unresectable.

Recurrence of spontaneous bacterial peritonitis in cirrhosis: Frequency and predictive factors

Llúcia Titó, Antoni Rimola, Pere Ginès, Josep Llach, Vicente Arroyo, Joan Rodés – 1 January 1988 – We investigated whether spontaneous bacterial peritonitis in cirrhosis is a recurrent process and attempted to identify possible predictors of recurrence in 75 consecutive cirrhotics who had recovered from a first episode of spontaneous bacterial peritonitis between January, 1981 and December, 1984 and who were followed closely throughout their illness (follow‐up period 10 ± 13 months; mean ± S.D.).

A candidate vaccine for hepatitis B containing the complete viral surface protein

Peter J. Kniskern, Arpi Hagopian, Pamela Burke, Nancy Dunn, Emilio A. Emini, William J. Miller, Shigeko Yamazaki, Ronald W. Ellis – 1 January 1988 – The entire surface protein of hepatitis B virus sero‐type ayw containing the preS (preS1+preS2) and S domains has been expressed in the yeast Saccharomyces cerevisiae. Yeast containing a recombinant plasmid utilizing a constitutive promoter did not express this gene successfully due to the toxicity of the protein.

Hepatic adenine nucleotide metabolism measured in vivo in rats fed ethanol and a high fat‐low protein diet

Kei Miyamoto, Samuel W. French – 1 January 1988 – Rats fed a diet high in fat and low in protein continuously infused by intragastric cannula were given ethanol for 2 to 6 months in order to examine the response of liver adenine nucleotides to changes in systemic PO2. Hepatic adenine nucleotides were measured in vivo monthly using liver obtained by biopsy from rats while a high blood alcohol level was maintained. Ethanol decreased hepatic ATP and the total adenylate pool, but did not change the levels of ADP and AMP. Adenylate energy charge showed only a tendency to be decreased.

Iron metabolism in the erythrophagocytosing Kupffer cell

Hitoshi Kondo, Kainosuke Saito, Joseph P. Grasso, Philip Aisen – 1 January 1988 – Like the peritoneal macrophage, the isolated Kupffer cell is capable of processing and releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells. When erythrophagocytosis is restrained to levels which do not affect cell viability, or less than 1.5 red cells/macrophage (phagocytic index of 150%), over 40% of iron acquired from red cells is released within 24 hr. More active erythrophagocytosis results in greater release of iron but progressive deterioration in cell viability.

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