Janna C. Collins, Allan W. Wolkoff, Anatol G. Morell, Richard J. Stockert – 1 January 1988 – Expression of three hepatocellular membrane proteins—the asialoglycoprotein receptor (hepatic binding protein) the insulin receptor and organic anion binding protein—have been studied in the HepG2 cell line. HepG2 grown in minimal essential medium supplemented with 10% fetal bovine serum maximally expressed hepatic binding protein and insulin receptor only at confluence while organic anion binding protein appeared independent of the state of cellular proliferation.

Gudrun Lindh, Ola Weiland, Hans Glaumann – 1 January 1988 – A numerical scoring system was applied and compared with conventional histological classification to assess the histological outcome in 42 patients with chronic hepatitis B followed for 16 to 162 months (mean = 75 months). Four histological categories in the biopsies were assessed and scored: (i) piecemeal necrosis; (ii) lobular necrosis; (iii) portal inflammation, and (iv) fibrosis and cirrhosis.

Shin Ohnishi, Hiromu Aoyama, Junji Shiga, Yuji Itai, Takashi Moriyama, Takashi Ishikawa, Nobuo Sasaki, Koshi Yamamoto, Kaoru Koshimizu, Shuichi Kaneko, Seishi Murakami, Nobu Hattori, Michio Imawari – 1 January 1988 – A new cell line derived from a woodchuck hepatitis surface antigen‐positive woodchuck hepatocellular carcinoma has been established and named T3‐HEP‐W1. This new cell line was established directly from a primary woodchuck hepatocellular carcinoma. Adaptation of the cells to the in vitro culture condition was completed after 3 months, with the doubling time of 24 hr.

Mary J. Ruwart, Bob D. Rush, Karen F. Snyder, Ken M. Peters, Henry D. Appelman, Keith S. Henley – 1 January 1988 – Chronic nutritional injury was induced in rats by a high‐fat, lipotrope‐deficient diet. The hepatoprotective effect of 16,16‐dimethyl prostaglandin E2 on the deposition of collagen and fat was assessed by histological evaluation and measurement of hydroxyproline. Dose‐response studies established that optimal protection was achieved by the twice daily administration of 16,16‐dimethyl prostaglandin E2 at 100 μg per kg (subcutaneous) or 250 μg per kg (oral).

John Dich, Constance Vind, Niels Grunnet – 1 January 1988 – (i) Hepatocytes isolated from adult rats were cultured for 2 to 3 weeks on collagen in a modified, serum‐free Waymouth medium containing fatty acids and varying concentrations of glucocorticoid, insulin and glucagon. (ii) In the presence of all three hormones, it was possible to maintain the content of DNA, the activity of glucokinase, pyruvate kinase, hexokinase and lactate dehydrogenase at initial levels for 2 to 3 weeks. The activity of glucokinase and pyruvate kinase was affected by the concentration of insulin.

Dominique Valla, Catherine Girod, Samuel S. Lee, Alain Braillon, Didier Lebrec – 1 January 1988 – Due to the marked effects of hemorrhage on cardiac output and splanchnic hemodynamics, the circulatory actions of vasopressin may differ during bleeding as opposed to stable conditions. We evaluated this hypothesis in conscious rats with portal hypertension due to chronic portal vein stenosis, by comparing the effects of a vasopressin infusion (0.02 IU per kg per min) to those of a control saline infusion, during and after a hypoten‐sive hemorrhage (25 ml per kg).

Oliver E. Owen – 1 November 1987 – The purpose of this study was to investigate the effect of interleukin 1 (IL 1) on glucocorticoid‐regulated hepatic metabolism. Steroid binding in liver cytosol, plasma glucose, plasma corticoster‐one, and phosphenolpyruvate carboxykinase (PEPCK) activity were assayed in C3H/HeJ mice after IL 1 administration. Mice received 5 pyrogenic U (PU) of rabbit IL 1 i.p. and were sacrificed 4 hr later.

Marshall J. Orloff – 1 November 1987 – Nine patients with Budd‐Chiari syndrome (BCS) were treated by a portal systemic shunt. One had thrombosis of the superior mesenteric vein (SMV) and another had complete obstruction of the retrohepatic inferior vena cava (IVC). All other patients had a marked stenosis of the retrohepatic IVC with caval pressure ranging from 12 to 24 mmHg (mean: 17 mmHg). Seven patients had an interprosition mesocaval shunt using an autologous jugular vein. The patient with a thrombosed SMV had a portoartial shunt.

Jean‐Pierre Villeneuve, Claire Infante‐Rivard, Serge Erlinger, Didier Lebrec – 1 November 1987

Haim Matzkin – 1 November 1987 – Large‐scale epidemics of non‐B (HBsAg‐negative) hepatitis have occurred in the Israel Defense Forces prior to post‐ and preexposure immune serum globulin administration. Presently, hepatitis morbidity rates have stabilized around 1 to 2 per 1,000. Several years after vaccine initiation, a comparison of epidemiological features was made in order to redefine risk groups.