The epidemiology and clinical outcome of hepatitis D virus (delta) infection in Jordan

Ala U. Toukan, Omayma A. Abu‐El‐Rub, Salwa A. Abu‐Laban, Musleh S. Tarawneh, M. Feisal Kamal, Stephen C. Hadler, Krzysztof Krawczynski, Harold S. Margolis, James E. Maynard – 1 November 1987 – The epidemiology and clinical outcome of hepatitis D viral infection in HBsAg‐positive acute hepatitis, chronic liver disease, primary hepatocellular carcinoma and the symptomless carrier state was studied in Jordan.

Hepatitis B vaccination of newborn infants: Clinical study of new vaccine formulation and dose regimen

Keun Soo Lee, Hahng Lee, Soo Jee Moon, Kyu Jong Choi, Ki Hong Kim, Chun Won Kim, Wha Soon Chung, Tae Yael Choi – 1 September 1987 – To investigate the efficacy in anti‐HBsAg response with half the recommended adult dose in a standard vaccination schedule or with a full dose in reduced number of vaccination schedule, 201 healthy newborn infants were randomized to receive either 2.5 μg Hevac B vaccine at birth [1, 2 and 14 months in Group I (101)] or 5 μg at birth [2 and 14 months in Group II (100)]. Anti‐HBsAg responses in the two groups were compared.

Antibodies to polymerized human serum albumin in acute and chronic liver disease

William M. Lee, Lizabeth McLeod, Kylie Martin, David L. Emerson, Robert M. Galbraith – 1 September 1987 – Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA.

Fatty acid‐binding protein: A major contributor to the ethanol‐induced increase in liver cytosolic proteins in the rat

Jean‐Pierre Pignon, Naila C. Bailey, Enrique Baraona, Charles S. Lieber – 1 September 1987 – To study the acute and chronic effects of ethanol on hepatic fatty acid‐binding protein, rats were pair‐fed with liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 4 to 5 weeks. Animals were killed 90 min after intragastric administration of diets with or without ethanol. Alcohol feeding markedly increased liver triglycerides, with a modest rise in nonesterified fatty acids.

Diminished serum Gc (vitamin D‐binding protein) levels and increased Gc:G‐actin complexes in a hamster model of fulminant hepatic necrosis

William M. Lee, David L. Emerson, William O. Young, Pascal J. Goldschmidt‐Clermont, David J. Jollow, Robert M. Galbraith – 1 September 1987 – Evidence for increased plasma levels of complexes containing Gc (vitamin D‐binding protein) and cellular actin has been previously reported during fulminant hepatic necrosis in man. In order to study this process in more detail, we produced liver injury in hamsters using increasing doses of acetaminophen, with serial collection of sera for up to 168 hr after acetaminophen injection.

A population study on the prevalence of gallstone disease: The sirmione study

Luigi Barbara, Claudia Sama, Antonio Maria Morselli Labate, Francesco Taroni, Anna Giulia Rusticali, Davide Festi, Carlo Sapio, Enrico Roda, Claudio Banterle, Armando Puci, Franco Formentini, Silvia Colasanti, Francesco Nardin – 1 September 1987 – The prevalence of gallstone disease (cholelithiasis and previous cholecystectomy for gallstones) in the population of the town of Sirmione, Italy, examined by ultrasonography, was 6.7% in men and 14.6% in women, ranging from 18 to 65 yr of age (overall prevalence = 11%).

Bile salt shift from albumin to high‐density lipoprotein in cholestasis

Hans‐Peter Buscher, Mathias Beger, Hella Sauerbier, Wolfgang Gerok – 1 September 1987 – The distribution of [3H]taurocholate between albumin and the lipoproteins of serum of patients with various diseases in which lipoprotein metabolism and/or bile salt concentrations were altered and of healthy control subjects was investigated by means of the density gradient centrifugation method. 1In control sera, bile salts distribute mainly between albumin and high‐density lipoprotein.

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