Gudrun Lindh, Ola Weiland, Hans Glaumann – 1 January 1988 – A numerical scoring system was applied and compared with conventional histological classification to assess the histological outcome in 42 patients with chronic hepatitis B followed for 16 to 162 months (mean = 75 months). Four histological categories in the biopsies were assessed and scored: (i) piecemeal necrosis; (ii) lobular necrosis; (iii) portal inflammation, and (iv) fibrosis and cirrhosis.

Janna C. Collins, Allan W. Wolkoff, Anatol G. Morell, Richard J. Stockert – 1 January 1988 – Expression of three hepatocellular membrane proteins—the asialoglycoprotein receptor (hepatic binding protein) the insulin receptor and organic anion binding protein—have been studied in the HepG2 cell line. HepG2 grown in minimal essential medium supplemented with 10% fetal bovine serum maximally expressed hepatic binding protein and insulin receptor only at confluence while organic anion binding protein appeared independent of the state of cellular proliferation.

Ursula Sommerer, Ellen R. Gordon, Carl A. Goresky – 1 January 1988 – Bilirubin monoglucuronide monoglucoside diester is one of the principal bilirubin conjugates in dog bile (and a lesser conjugate, in human bile), and bilirubin diglucoside is an occasional trace conjugate in dog bile whereas, in contrast, neither is detectable in rat bile.

Patricia S. Latham – 1 January 1988 – Reye's syndrome (RS) is generally considered a childhood disease. We report our experience with RS in adults in the metropolitan Milwaukee area. Reye's syndrome was diagnosed in seven 18‐ to 46‐year‐old adults.

Charles J. Lightdale – 1 January 1988 – Laparoscopic findings of the liver in 13 cases with primary biliary cirrhosis (PBC) diagnosed by wedge or needle biopsy were investigated. The characteristic features of laparoscopic appearance—gentle undulation—were observed in 11 out of 13 (85%) patients with PBC. These gentle undulations were irregularly shaped areas from 0.5 to 3 cm in diameter. Those observed in s‐PBC were greater in number and more pronounced than those in a‐PBC.

Thomas J. Romano – 1 January 1988

Peter A. Berg, Reinhild Klein, Toshihiko Namihisa, Hideo Ishii, Emanuel Sikuler, Gerald M. Fraser, Osamu Nishida – 1 January 1988

Hitoshi Kondo, Kainosuke Saito, Joseph P. Grasso, Philip Aisen – 1 January 1988 – Like the peritoneal macrophage, the isolated Kupffer cell is capable of processing and releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells. When erythrophagocytosis is restrained to levels which do not affect cell viability, or less than 1.5 red cells/macrophage (phagocytic index of 150%), over 40% of iron acquired from red cells is released within 24 hr. More active erythrophagocytosis results in greater release of iron but progressive deterioration in cell viability.

Kei Miyamoto, Samuel W. French – 1 January 1988 – Rats fed a diet high in fat and low in protein continuously infused by intragastric cannula were given ethanol for 2 to 6 months in order to examine the response of liver adenine nucleotides to changes in systemic PO2. Hepatic adenine nucleotides were measured in vivo monthly using liver obtained by biopsy from rats while a high blood alcohol level was maintained. Ethanol decreased hepatic ATP and the total adenylate pool, but did not change the levels of ADP and AMP. Adenylate energy charge showed only a tendency to be decreased.

Peter J. Kniskern, Arpi Hagopian, Pamela Burke, Nancy Dunn, Emilio A. Emini, William J. Miller, Shigeko Yamazaki, Ronald W. Ellis – 1 January 1988 – The entire surface protein of hepatitis B virus sero‐type ayw containing the preS (preS1+preS2) and S domains has been expressed in the yeast Saccharomyces cerevisiae. Yeast containing a recombinant plasmid utilizing a constitutive promoter did not express this gene successfully due to the toxicity of the protein.