Lennox J. Jeffers, Richard A. Dubow, Leslie Zieve, K. Rajender Reddy, Alan S. Livingstone, Sidney Neimark, Manuel Viamonte, Eugene R. Schiff – 1 January 1988 – A 40‐yr‐old man presented with encephalopathy and was found to have hepatocellular carcinoma without cirrhosis. A large vascular hepatic mass was defined by CT scan and angiography; laparoscopy with biopsy confirmed the absence of chronic liver disease. A definitive tissue diagnosis of hepatocellular carcinoma was made at laparotomy; the tumor was unresectable.

Llúcia Titó, Antoni Rimola, Pere Ginès, Josep Llach, Vicente Arroyo, Joan Rodés – 1 January 1988 – We investigated whether spontaneous bacterial peritonitis in cirrhosis is a recurrent process and attempted to identify possible predictors of recurrence in 75 consecutive cirrhotics who had recovered from a first episode of spontaneous bacterial peritonitis between January, 1981 and December, 1984 and who were followed closely throughout their illness (follow‐up period 10 ± 13 months; mean ± S.D.).

Charles H. Firth – 1 January 1988

Peter J. Kniskern, Arpi Hagopian, Pamela Burke, Nancy Dunn, Emilio A. Emini, William J. Miller, Shigeko Yamazaki, Ronald W. Ellis – 1 January 1988 – The entire surface protein of hepatitis B virus sero‐type ayw containing the preS (preS1+preS2) and S domains has been expressed in the yeast Saccharomyces cerevisiae. Yeast containing a recombinant plasmid utilizing a constitutive promoter did not express this gene successfully due to the toxicity of the protein.

Kei Miyamoto, Samuel W. French – 1 January 1988 – Rats fed a diet high in fat and low in protein continuously infused by intragastric cannula were given ethanol for 2 to 6 months in order to examine the response of liver adenine nucleotides to changes in systemic PO2. Hepatic adenine nucleotides were measured in vivo monthly using liver obtained by biopsy from rats while a high blood alcohol level was maintained. Ethanol decreased hepatic ATP and the total adenylate pool, but did not change the levels of ADP and AMP. Adenylate energy charge showed only a tendency to be decreased.

Hitoshi Kondo, Kainosuke Saito, Joseph P. Grasso, Philip Aisen – 1 January 1988 – Like the peritoneal macrophage, the isolated Kupffer cell is capable of processing and releasing iron acquired by phagocytosis of immunosensitized homologous red blood cells. When erythrophagocytosis is restrained to levels which do not affect cell viability, or less than 1.5 red cells/macrophage (phagocytic index of 150%), over 40% of iron acquired from red cells is released within 24 hr. More active erythrophagocytosis results in greater release of iron but progressive deterioration in cell viability.

Peter A. Berg, Reinhild Klein, Toshihiko Namihisa, Hideo Ishii, Emanuel Sikuler, Gerald M. Fraser, Osamu Nishida – 1 January 1988

Thomas J. Romano – 1 January 1988

Charles J. Lightdale – 1 January 1988 – Laparoscopic findings of the liver in 13 cases with primary biliary cirrhosis (PBC) diagnosed by wedge or needle biopsy were investigated. The characteristic features of laparoscopic appearance—gentle undulation—were observed in 11 out of 13 (85%) patients with PBC. These gentle undulations were irregularly shaped areas from 0.5 to 3 cm in diameter. Those observed in s‐PBC were greater in number and more pronounced than those in a‐PBC.

Patricia S. Latham – 1 January 1988 – Reye's syndrome (RS) is generally considered a childhood disease. We report our experience with RS in adults in the metropolitan Milwaukee area. Reye's syndrome was diagnosed in seven 18‐ to 46‐year‐old adults.