Hepatic heme synthesis in a new model of experimental hemochromatosis: Studies in rats fed finely divided elemental iron
Herbert L. Bonkovsky, John F. Healey, Beth Lincoln, Bruce R. Bacon, David F. Bishop, George H. Elder – 1 November 1987 – Rats fed chow containing finely divided elemental iron (from carbonyl‐iron) develop hepatic iron overload resembling human hereditary hemochromatosis in that deposition of iron is primarily in periportal hepatocytes and with hepatic iron concentrations sufficiently high to be associated in the human disease with hepatic fibrosis or cirrhosis.