William M. Lee, David L. Emerson, William O. Young, Pascal J. Goldschmidt‐Clermont, David J. Jollow, Robert M. Galbraith – 1 September 1987 – Evidence for increased plasma levels of complexes containing Gc (vitamin D‐binding protein) and cellular actin has been previously reported during fulminant hepatic necrosis in man. In order to study this process in more detail, we produced liver injury in hamsters using increasing doses of acetaminophen, with serial collection of sera for up to 168 hr after acetaminophen injection.

Jean‐Pierre Pignon, Naila C. Bailey, Enrique Baraona, Charles S. Lieber – 1 September 1987 – To study the acute and chronic effects of ethanol on hepatic fatty acid‐binding protein, rats were pair‐fed with liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 4 to 5 weeks. Animals were killed 90 min after intragastric administration of diets with or without ethanol. Alcohol feeding markedly increased liver triglycerides, with a modest rise in nonesterified fatty acids.

William M. Lee, Lizabeth McLeod, Kylie Martin, David L. Emerson, Robert M. Galbraith – 1 September 1987 – Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA.

Keun Soo Lee, Hahng Lee, Soo Jee Moon, Kyu Jong Choi, Ki Hong Kim, Chun Won Kim, Wha Soon Chung, Tae Yael Choi – 1 September 1987 – To investigate the efficacy in anti‐HBsAg response with half the recommended adult dose in a standard vaccination schedule or with a full dose in reduced number of vaccination schedule, 201 healthy newborn infants were randomized to receive either 2.5 μg Hevac B vaccine at birth [1, 2 and 14 months in Group I (101)] or 5 μg at birth [2 and 14 months in Group II (100)]. Anti‐HBsAg responses in the two groups were compared.

Harold O. Conn, Johan Fevery – 1 September 1987

1 September 1987

Claire Infante‐Rivard, Santiago Esnaola, Jean‐Pierre Villeneuve – 1 July 1987 – The objective of this study was to assess the prognostic validity of Child‐Turcotte classification with regard to short‐term (1‐year) survival. The Child‐Turcotte classification, as modified by Pugh et al., was recorded on admission in 177 cirrhotic patients. The variables that comprise the Pugh modification are ascites, encephalopathy, serum albumin, serum bilirubin and prothrombin time.

Peter Van Der Sluijs, Bart Postema, Dirk K. F. Meijer – 1 July 1987 – Two types of models have recently been proposed to describe hepatic uptake kinetics of protein bound drugs: a model in which dissociation from plasma protein is rate limiting the process, and a model in which an interaction between protein and hepatocyte surface is thought to promote dissociation and uptake of the drug. This study was designed to investigate several aspects of both models, using lactosylated albumin as a binding protein that can interact with the Ashwell receptor abundantly present on the hepatocyte.

Wolfgang Hagmann, Anne‐Marie Steffan, André Kirn, Dietrich Keppler – 1 July 1987 – The role of leukotrienes was investigated in frog virus 3‐induced hepatitis in rats. Frog virus 3 elicited an enhanced generation of cysteinyl leukotrienes in vivo as monitored by measurement of N‐acetyl‐leukotriene E4 as the major endogenous metabolite of cysteinyl leukotrienes secreted into rat bile. N‐Acetyl‐leukotriene E4 concentrations were elevated for more than 4 hr after frog virus 3 injection.

Allan W. Wolkoff – 1 July 1987