Inhibition of gluconeogenesis by hypoglycin: Alternate interpretations

Kay Tanaka – 1 November 1987 – Treatment of rats with hypoglycaemic doses of hypoglycin has been shown to abolish the relative detritiation of [2‐3H, U‐14C]glucose [Osmundsen, Billington, Taylor & Sherratt (1978) Biochem. J. 170, 337–342], indicating that both the Cori and the glucose/glucose 6‐phosphate cycles were inhibited in vivo. This inhibition was confirmed and, in addition, it was shown that the conversion in vivo of both [14C]lactate and [14C]fructose into glucose was decreased after hypoglycin treatment.

Oriental hornet venom‐induced hepatic injury: The first animal‐produced hepatotoxin?

HYMANJ. ZIMMERMAN – 1 November 1987 – The hepatotoxic effect of venom sac extract (VSE) of the Oriental hornet has already been demonstrated using the well‐known models of experimental toxicology: in vivo, isolated in situ and in vitro. The present work deals with a series of 48 rats treated daily with 5 mg VSE/kg body weight for 1–14 days. Serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ‐glutamyl transferase (GGT) were measured. Liver tissue fractionation was performed.

Hepatic extraction of renin: Quantitation and characterization in the isolated perfused rat liver

Joan A. Keiser, Juan C. Romero, Louis J. Kost, Nicholas F. Larusso – 1 November 1987 – Since the liver is thought to be the major organ for the metabolism of renin, the rate‐limiting enzyme in the renin‐angiotensin cascade, we examined the kinetics and regulation of renin extraction by the isolated perfused rat liver. Partially purified, hog kidney renin was continuously infused into isolated rat livers perfused in a nonrecirculating manner with serum‐free medium.

α1‐Adrenergic effects and liver regeneration

Jennifer L. Cruise, Stuart J. Knechtle, R. Randal Bollinger, Cynthia Kuhn, George Michalopoulos – 1 November 1987 – The effects of several treatments involving α‐adrenergic mechanisms upon the early stages of rat liver regeneration were examined. Catecholamine concentrations in rat plasma were measured at various times after hepatectomy and were found to be elevated relative to those in plasma from sham‐operated rats.

Serum type III procollagen and basement membrane proteins as noninvasive markers of hepatic pathology in Indian childhood cirrhosis

Premila Trivedi, Juha Risteli, Leila Risteli, M. Stuart Tanner, Sheila Bhave, Anand N. Pandit, Alex P. Mowat – 1 November 1987 – While serum concentrations of antigens of the aminopropeptide of type III procollagen have been considered as indicators of hepatic pathology in adults, the high concentrations normally found in children during growth may preclude their use in pediatric liver disease.

Immunoelectron microscopic observations on the inflammatory infiltrates and HLA antigens in hepatitis B and non‐A, Non‐B

Hans P. Dienes, Thomas Hütteroth, Georg Hess, Stefan C. Meuer – 1 November 1987 – The present knowledge of the inflammatory reaction occurring in situ during hepatitis B favors a T cell‐dependent MHC‐restricted immune response. However, the reports in the literature are primarily based on the application of monoclonal antibodies directed at different lymphocyte subsets which discern only lymphocytic phenotypes and do not reflect the actual situation adequately.

Elevated HLA class i antigen expression on peripheral blood mononuclear cells of HBsAg carriers with coexistent human immunodeficiency virus infection

Robert G. Paul, Stanford T. Roodman, Deborah A. Paul, Robert P. Perrillo – 1 November 1987 – The density of HLA Class I antigen on peripheral blood mononuclear cells was evaluated by flow cytometry in the following groups of patients: 41 HBsAg carriers; 12 individuals with chronic non‐A, non‐B hepatitis, and 4 with acute hepatitis B. Fourteen of the carriers were positive for antibody to human immunodeficiency virus, and all were negative for antibody to delta agent. Elevated levels of Class I antigen were observed in only 19% of patients with chronic hepatitis B virus infection alone.

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