Graft‐versus‐host‐induced cirrhosis: Possible mechanisms
Howard M. Shulman – 1 November 1987 – A 28‐yr‐old woman with severe idiopathic aplastic anemia received an HLA‐identical mixed lymphocyte culture nonreactive bone marrow transplant from her brother. In the months after successful engraftment, she developed cutaneous and hepatic graft‐versus‐host disease, associated with marked cholestatic jaundice. Despite a series of therapeutic maneuvers, cholestasis persisted but remained relative stable over the enuing 10 yr. However, serial liver biopsies revealed progressive biliary‐type firbrosis culminating in cirrhosis.
Elsewhere correspondence
Stuart E. Lind, Daniel E. Singer, Klemens B. Meyer, Jerome P. Kassirer – 1 November 1987
The epidemiology and clinical outcome of hepatitis D virus (delta) infection in Jordan
Ala U. Toukan, Omayma A. Abu‐El‐Rub, Salwa A. Abu‐Laban, Musleh S. Tarawneh, M. Feisal Kamal, Stephen C. Hadler, Krzysztof Krawczynski, Harold S. Margolis, James E. Maynard – 1 November 1987 – The epidemiology and clinical outcome of hepatitis D viral infection in HBsAg‐positive acute hepatitis, chronic liver disease, primary hepatocellular carcinoma and the symptomless carrier state was studied in Jordan.
Bile pigments and jaundice: Molecular, metabolic and medical aspects. Edited by J. Donald Ostrow. 744 pp. New York: Marcel Dekker, Inc., 1986. $119.50
Harold O. Conn, Johan Fevery – 1 September 1987
Hepatitis B vaccination of newborn infants: Clinical study of new vaccine formulation and dose regimen
Keun Soo Lee, Hahng Lee, Soo Jee Moon, Kyu Jong Choi, Ki Hong Kim, Chun Won Kim, Wha Soon Chung, Tae Yael Choi – 1 September 1987 – To investigate the efficacy in anti‐HBsAg response with half the recommended adult dose in a standard vaccination schedule or with a full dose in reduced number of vaccination schedule, 201 healthy newborn infants were randomized to receive either 2.5 μg Hevac B vaccine at birth [1, 2 and 14 months in Group I (101)] or 5 μg at birth [2 and 14 months in Group II (100)]. Anti‐HBsAg responses in the two groups were compared.
Antibodies to polymerized human serum albumin in acute and chronic liver disease
William M. Lee, Lizabeth McLeod, Kylie Martin, David L. Emerson, Robert M. Galbraith – 1 September 1987 – Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA.
Fatty acid‐binding protein: A major contributor to the ethanol‐induced increase in liver cytosolic proteins in the rat
Jean‐Pierre Pignon, Naila C. Bailey, Enrique Baraona, Charles S. Lieber – 1 September 1987 – To study the acute and chronic effects of ethanol on hepatic fatty acid‐binding protein, rats were pair‐fed with liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 4 to 5 weeks. Animals were killed 90 min after intragastric administration of diets with or without ethanol. Alcohol feeding markedly increased liver triglycerides, with a modest rise in nonesterified fatty acids.
Diminished serum Gc (vitamin D‐binding protein) levels and increased Gc:G‐actin complexes in a hamster model of fulminant hepatic necrosis
William M. Lee, David L. Emerson, William O. Young, Pascal J. Goldschmidt‐Clermont, David J. Jollow, Robert M. Galbraith – 1 September 1987 – Evidence for increased plasma levels of complexes containing Gc (vitamin D‐binding protein) and cellular actin has been previously reported during fulminant hepatic necrosis in man. In order to study this process in more detail, we produced liver injury in hamsters using increasing doses of acetaminophen, with serial collection of sera for up to 168 hr after acetaminophen injection.