Kunio Okuda – 1 September 1987 – A total of 105 cases of fulminant hepatitis sen during the period fom January 1979 to December 1983 and filed by the pediatric services of major hospitals throughout Japan with the diagnostic criteria set by the 12th Inuyama Liver Symposium were analyzed. The male:Female atio was 2:1. Fifty‐six per cent of he cases werre younge than 2 years and 29.5% were thought to be due to hepaitis B infection. The majority of B‐type fulminant heptitis cases younger than 6 months not related to blood transfusion had been born to HBeAg‐negative caie mohers.

Flavio Moroni, Oliviero Riggio, Vincenzo Carlà, Vittorio Festuccia, Florio Ghinelli, Ignazio R. Marino, Manuela Merli, Laura Natali, Giovanni Pedretti, Franco Fiaccadori, Livio Capocaccia – 1 September 1987 – The aim of the study was to verify the role of γ‐aminobutyric acid in the pathogenesis of hepatic encephalopathy occurring in cirrhotic patients by attempting to correlate plasma and cerebrospinal fluid content of authentic γ‐aminobutyric acid with the neurological manifestations of hepatic encephalopathy.

Rafael E. Cuellar, Ralph Tarter, Amy Hays, David H. Van Thiel – 1 September 1987 – A case of a 20‐yr‐old female with possible “alcoholic hepatitis” and a mixed micro/macronodular cirrhosis occurring in association with overt bulimia and a history of anorexia nervosa, but without any objective evidence of either alcoholism or alcohol abuse, is reported. The possible factors that may have contributed, either alone or in combination, to produce this unusual occurrence are discussed.

Donald M. Small – 1 September 1987 – Although bile acid and bile lipid metabolism have been studied in established cholelithiasis, little is known about them in patients destined to develop gall stones, but in whom the stones have not yet appeared (prestone gall stone disease). After confirmed complete gall stone dissolution and withdrawal of treatment, gall stones recur frequently.

Ousama E. Moussa, Harold O. Conn – 1 September 1987 – Since 1976, we have compared the end‐to‐side portacaval shunt (PCS) with the distal splenorenal shunt (DSRS) in patients with alcoholic liver disease and recurrent variceal bleeding. Fifty‐four patients were randomly assigned to receive either shunt procedure. There were 27 patients in each group and both groups were highly comparable in clinical and laboratory characteristics. Median follow‐up was 31 mo in each group. Postoperative complications and operative mortality (7% after PCS, 12% after DSRS) were comparable.

Michael Bennick – 1 September 1987

Cynthia Cohen – 1 September 1987 – Liver cell dysplasia (LCD) is a premalignant cytologic change of hepatocytes that has been statistically linked to cirrhosis, hepatocellular carcinoma (HCC), and chronic liver disease related to hepatitis B virus. The relationship of LCD to non‐A, non‐B (NANB) hepatitis is currently unknown. We studied liver biopsy and surgical resection specimens from 36 patients with NANB hepatitis, and identified LCD in 17 (42.5%) of 40 specimens, most often associated with cirrhosis.

Guadalupe Garcia‐Tsao, Roberto J. Groszmann – 1 September 1987 – Nitroglycerin is a potent venous dilator and a mild arterial vasodilator that has been shown to improve the hemodynamic response to vasopressin in portal hypertensive patients and to decrease portal pressure in experimental animals. In order to determine the effect of nitroglycerin on portal venous hemodynamics, we studied 11 patients with alcoholic cirrhosis before and during the administration of sublingual nitroglycerin (0.4 and 0.6 mg).

Raf Sciot, Alan C. Paterson, Joost J. Van Den Oord, Valeer J. Desmet – 1 September 1987 – The major part of hepatocellular iron is derived from uptake of transferrin‐bound iron by means of nonspecific fluid‐phase endocytosis and specific, saturable binding on high‐affinity transferrin receptors. We investigated the expression of transferrin receptors on hepatocytes in liver biopsies of 22 cases of hemochromatosis (21 primary hemochromatosis and 1 secondary hemochromatosis), using immunohistochemical demonstration of the human transferrin receptor with the specific monoclonal antibody OKT9.

Heidrun Matern, Heinz‐Herbert Fiebig, Siegfried Matern – 1 September 1987 – Human hepatoma which had been xenografted into nude mice have been estimated for their ability to catalyze glucuronic acid and glucose conjugation of endogenous compounds and p‐nitrophenol. The xenobiotic p‐nitrophenol was glucuronidated with a comparable rate in microsomes from human hepatoma, human liver and host liver.