Helmut Denk – 1 September 1987 – Livers from 12 mice fed griseofulvin for 4 to 6 months were perfused in situ with a detergent solution to extract lipid membranes leaving the cytoskeleton intact. Seven control mice were similarly studied. After 30 to 120 minutes perfusion, liver samples were examined by scanning electron microscopy and transmission electron microscopy. By light microscopy, Mallory bodies (MBs) were observed in pericentral hepatocytes. These were confirmed by transmission electron microscopy. Intermediate filaments (IFs) were observed in close apposition to MBs.

1 September 1987

Seigo Kitano, Nobuhiro Koyanagi, Yasunori Iso, Hidefumi Higashi, Keizo Sugimachi – 1 September 1987 – Endoscopic injection sclerotherapy was given to 155 patients with esophageal varices mainly related to non‐alcoholic liver cirrhosis. The formation of a superficial ulcer in the lower esophagus was achieved in 141 (91.0%) of the 155 patients, with an average of 4.1 sessions of endoscopic injection sclerotherapy during an average time of 4.9 weeks.

Udaya M. Kabadi – 1 September 1987 – Hyperammonemia is a well‐recognized metabolic abnormality which occurs in cirrhotic patients with advanced liver dysfunction. We recently documented that hyperglucagonemia that occurs as a result of hepatic glycogen depletion may be responsible for this hyperammonemia by promoting gluconeogenesis to provide glucose as a fuel for functioning of several organ systems. Thus, hepatic glycogen depletion may be the initial process responsible for hyperammonemia.

Ineke Braakman, Geny Martha Maria Groothuis, Dirk Klaas Fokke Meijer – 1 September 1987 – We studied a possible acinar heterogeneity in the transport of organic cations, using rhodamine B as model compound. Employing perfusions of isolated rat livers in the ante‐ and retrograde mode and quantitative fluorescence microscopy, Zones 1 and 3 were shown to be equally efficient in taking up rhodamine B. Ten minutes after injection in an antegrade perfusion, 95% of the dose was localized in the portal half of the acinus.

W. Wayne Lautt, Clive V. Greenway – 1 September 1987

Gregory J. Gores, S. Breanndan Moore, Lloyd D. Fisher, Frank C. Powell, E. Rolland Dickson – 1 September 1987 – Tissue injury in primary biliary cirrhosis is thought to be mediated by immune mechanisms. Various Class II antigens of the major histocompatibility complex are associated with autoimmune diseases and their differing clinical manifestations. Thus, the aim of this study was to examine the relationship between primary biliary cirrhosis, its clinical manifestations and serologically defined Class II antigens (HLA‐DR and HLA‐DQ).

Michael Manns, Guido Gerken, Apostolos Kyriatsoulis, Christian Trautwein, Konrad Reske, Karl‐Hermann Meyer Zum Büschenfelde – 1 September 1987 – Antimitochondrial antibodies from patients with primary biliary cirrhosis react with different mitochondrial polypeptides as demonstrated by Western blots.

James G. Corasanti – 1 September 1987

Gavino Faa, Carla Liguori, Amedeo Columbano, Giacomo Diaz – 1 September 1987 – The pattern of copper distribution in human newborn liver was investigated by histochemical methods (rhodamine, orcein and rubeanic acid) and by atomic absorption spectroscopy. A significant correlation (p < 0.005) was found between the degree of histochemical positivity and the copper concentration found by atomic absorption spectroscopy.