Domenico Pugliese, Samuel S. Lee, Abraham Koshy, Raimondo Cerini, Yves Ozier, Didier Lebrec – 1 May 1988 – In animals, there may exist a hyperemic response in the portal circulation during intravenous administration of hypertonic glucose, but a hemodynamic response of this kind has never been described in man. This study was designed to evaluate if hyperglycemia itself could induce systemic or splanchnic hemodynamic changes in patients with cirrhosis. Sixteen patients with cirrhosis were studied before and during i.v.

Frank Iber – 1 May 1988

N. J. Talley – 1 May 1988

1 May 1988

Shinichi Kakumu, Akihiko Fuji, Kentaro Yoshioka, Hirofumi Tahara, Yoshiyuki Ohtani, Hideo Hirofuji, Kenichi Murase, Tsuneto Aoi – 1 May 1988 – Recombinant human interleukin 2 was administered to 10 patients with chronic type B hepatitis as a part of a pilot study to evaluate its antiviral activity. Patients received 1 to 3 x 105 units per day of interleukin 2 for 21 to 28 days, and all completed the treatment schedule. During therapy, serum values of DNA polymerase decreased in 6 and became negative in four patients.

John S. Freiman, Allison R. Jilbert, Robert J. Dixon, Marlis Holmes, Eric J. Gowans, Christopher J. Burrell, Edward J. Wills, Yvonne E. Cossart – 1 May 1988 – Seventy, 1‐day‐old ducklings inoculated intraperitoneally with duck hepatitis B virus and 30 controls have been studied over a 2‐year period. Infection with duck hepatitis B virus occurred in all inoculated ducks, although this was not associated with clinical morbidity.

Samuel S. Lee, Antoine Hadengue, Richard Moreau, Raymond Sayegh, Patrick Hillon, Didier Lebrec – 1 May 1988 – The hemodynamic response to a 800 kcal liquid meal was investigated in 24 patients (study group) with cirrhosis and two control groups. One control group of six cirrhotic patients (volume control) had a calorie‐free equivolumic electrolyte solution. The second control group (normal control) of six patients with normal hepatic function had the same test meal.

Luigi Bolondi, Stefano Gaiani, Alighieri Mazziotti, Paolo Casanova, Antonino Cavallari, Giuseppe Gozzetti, Luigi Barbara – 1 May 1988 – We investigated a group of patients who underwent distal splenorenal shunt using high‐resolution real‐time equipment and a duplex scanner with the aims: (i) to evaluate the rate of visualization of shunt; (ii) to assess change in size in the portal vein, and (iii) to characterize the flow pattern in the splenic vein and to study flow direction and velocity in the portal vein, thus adding new data on the efficacy of this operation in maintaining hepatic perf

Estela Monteiro, M. Patricia Alves, M. Livia Santos, Isabel Quintas, Amelia Baptista, Alberto Galvao‐Teles, Judith S. Gavaler – 1 May 1988 – The distribution of six HLA antigens in a population of 88 Portuguese chronic alcohol abusers with biopsy‐proven liver disease was compared to that in 66 Portuguese normal controls.

Reidar Albrechtsen, Ulla M. Wewer, Snorri S. Thorgeirsson – 1 May 1988 – De novo formation of laminin‐positive basement membranes was found to be a distinct morphologic feature of diethylnitrosamine/phenobarbital‐induced hepatocellular carcinomas of the rat. The first appearance of extracellularly located laminin occurred in the pre‐neoplastic liver lesions (corresponding to neoplastic nodules), and this feature became successively more prominent during the course of hepatocellular carcinoma development.