David S. Zimmon – 1 May 1988 – Original Gianturco expandable stents and their modifications were used to create an experimental intra‐hepatic portacaval anastomosis (EIPCA) in 30 young domestic swine without portal hypertension. The study focused on the design of a suitable stent, the technique of its application, the the evaluation of short‐term patency of the EIPCA. A stent with a 2.5‐cm‐long body and wire skirts on both ends was most suitable for EIPCA creation.

Pere Ginès, Wladimiro Jiménez, Vicente Arroyo, Miquel Navasa, Clara López, Llúcia Titó, Antoni Serra, Jaime Bosch, Ginès Sanz, Francisca Rivera, Joan Rodés – 1 May 1988 – The aim of this study was to determine the plasma levels, cardiac release and splanchnic extraction of atrial natriuretic factor in cirrhosis with ascites. The plasma concentration of immunoreactive atrial natriuretic factor in samples obtained from an antecubital vein was measured in 18 healthy volunteers and in 35 cirrhotics with ascites.

Ulrich Spengler, Gerd R. Pape, Robert M. Hoffmann, Judith P. Johnson, Josef Eisenburg, Gustav Paumgartner, Gert Riethmüller – 1 May 1988 – To study the expression of MHC Class II subregion gene products on biliary epithelial cells in primary biliary cirrhosis, frozen sections from liver biopsies of 15 patients with primary biliary cirrhosis were studied immunohistochemically using HLA‐D subregion specific monoclonal antibodies L243 (HLA‐DR), Leu10 (HLA‐DQ) and B7/21 (HLA‐DP).

Stephanos J. Hadziyannis – 1 May 1988 – A controlled trial of lymphoblastoid interferon versus no therapy in patients positive for HBsAg, HBeAg and DNA polymerase activity with separate randomisation for sexual preference and histology is underway. Thirty‐two patients have been followed for a minimum period of 6 months of whom 15 have been randomised to receive interferon thrice weekly for 6 months after a 5‐day induction phase.

Jay W. Marks – 1 May 1988 – The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each patient was dissolved in ethanol/ether to determine cholesterol and matrix composition. The remaining two matched stones were dissolved in either monoctanoin plus ethanol (n = 86) or monooctanoin plus 2‐mercaptoethanol (n = 86).

Yoshinori Katsuma, Normand Marceau, Masaharu Ohta, Samuel W. French – 1 May 1988 – A new method of visualizing the three‐dimensional architecture of the cytokeratin filaments of the intact rat hepatocyte in situ has been achieved. Frozen sections of liver cut 10 μm thick were serially extracted to remove all elements of the cells except the intermediate filaments. Parallel sections were stained with monoclonal antibodies to the two main cytokeratins found in bile duct and liver cells.

Howard M. Shulman, Pankaj Sharma, Deborah Amos, L. Frederick Fenster, George B. McDonald – 1 May 1988 – We tested the hypothesis that liver histology from patients with graft‐versus‐host disease could be distinguished from other common liver diseases. Liver biopsies from 33 allogeneic marrow transplant recipients with acute and chronic graft‐versus‐host disease and 37 nontransplant liver disease patients without graft‐versus‐host disease were recut, restained and coded for blind review.

Horace A. Laffaye – 1 May 1988

Dale A. Parks, D. Neil Granger – 1 May 1988

Yuji Yoshikawa, Yoichi Sakata, Gotaro Toda, Hiroshi Oka – 1 May 1988 – Protein C, one of the vitamin K‐dependent plasma proteins synthesized in the liver, was measured immunologically in normal subjects (n = 20), patients with hepatocellular carcinoma (n = 60), liver cirrhosis (n = 60), acute hepatitis (n = 16), chronic hepatitis (n = 19), malignant neoplasms other than hepatocellular carcinoma (n = 35) and patients on warfarin treatment (n = 20).