Masthead
1 May 1988
Systemic and splanchnic hemodynamic effects of intravenous hypertonic glucose in patients with cirrhosis
Domenico Pugliese, Samuel S. Lee, Abraham Koshy, Raimondo Cerini, Yves Ozier, Didier Lebrec – 1 May 1988 – In animals, there may exist a hyperemic response in the portal circulation during intravenous administration of hypertonic glucose, but a hemodynamic response of this kind has never been described in man. This study was designed to evaluate if hyperglycemia itself could induce systemic or splanchnic hemodynamic changes in patients with cirrhosis. Sixteen patients with cirrhosis were studied before and during i.v.
Identification of biliprotein as a liver growth factor
Juan J. Díaz‐Gil, Gonzalo Sánchez, Carolina Trilla, Pedro Escartín – 1 May 1988 – We determined the concentration of biliprotein in plasma of rats at different times after partial hepatectomy. From the same plasma samples, we purified a liver growth factor previously characterized by our group. When we plotted the 14 points studied, a linear relationship was obtained (r = 0.999; p < 0.001). This result, in addition to our group's recent identification of this liver growth factor as an albumin‐bilirubin complex, strongly suggests that biliprotein is a liver growth factor.
HLA class I antigen display on hepatocyte membrane in chronic hepatitis B virus infection: Its role in the pathogenesis of chronic type B hepatitis
Chia‐Ming Chu, Wei‐Chue Shyu, Ruey‐Wen Kuo, Yun‐Fan Liaw – 1 May 1988 – It has been suggested that cytotoxic T cells are involved in the recognition and lysis of the infected hepatocytes in chronic hepatitis B virus infection, and that the target antigen is probably HBcAg which is displayed on the hepatocyte membrane during active viral replication. However, studies in other viral infection have demonstrated that cytotoxic T cells recognize viral antigen on the infected cells only in the context of HLA class I antigens.
Antigen presentation and autoimmunity
Paul M. Allen – 1 May 1988
Ethinylestradiol stimulates a biliary cholesterol‐phospholipid cosecretion mechanism in the hamster
Frieder Berr, Frans Stellaard, Alwin Goetz, Claus Hammer, Gustav Paumgartner – 1 May 1988 – The mechanism of ethinylestradiol‐induced biliary secretion of excess cholesterol, a potential causative factor of cholesterol gallstones, is not yet known. It might be related to altered bile acid metabolism, since the rate of cholesterol and phospholipid secreted into bile is thought to be influenced by the hydrophobicity of the bile acid species secreted.
Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase
Jacques Metzger, Srinath P. Dore, Bernhard H. Lauterburg – 1 May 1988 – Oxygen‐derived free radicals might play a role in the injury produced by reperfusion of ischemic organs. Since the generation of reactive oxygen species results in an increased formation of glutathione disulfide, we have attempted to document an oxidant stress during reperfusion of ischemic liver by following the hepatic production of glutathione disulfide in vivo and in the perfused rat liver.