Alterations of hepatic enzyme levels and of the acinar distribution of glutamine synthetase in response to experimental liver injury in the rat
Rolf Gebhardt, Hans‐Jörg Burger, Hans Heini, Karl‐Ludwig Schreiber, Dieter Mecke – 1 July 1988 – Glutamine synthetase shows a striking heterogeneous distribution in normal rat liver as consistently revealed by immunohistochemistry using a specific antiserum against the rat liver enzyme or a cross‐reacting antiserum. The effects of zonal liver injury induced by allylformate or CC14 on this distribution and on the activity of glutamine synthetase as well as of enzymes with different acinar distribution were investigated.