David Y. Graham – 1 July 1988

1 July 1988

Yoram Bujanover, Sergio Amarri, Emanuel Lebenthal, James K. Petell – 1 July 1988 – The regulation of different maturational processes in the liver is believed to be influenced by the hormonal system. The aim of this study was to investigate the effect of two hormones, glucagon and dexamethasone, on levels of plasma membrane proteins in rat liver cells during late fetal and early postnatal stages of development.

Gilbert Reibnegger, Ingeborg Auhuber, Dietmar Fuchs, Arno Hausen, Gert Judmaier, Christian Prior, Ernst R. Werner, Helmut Wachter – 1 July 1988 – Elevated neopterin levels in blood or urine have been shown to be a marker for the activation of cell‐mediated immunity in vitro and in vivo.

The Rome Group for Epidemiology and Prevention of Cholelithiasis (GREPCO) – 1 July 1988 – The epidemiological associations of gallstone disease were evaluated in a population of 2,325 civil servants (1,244 men and 1,081 women) in Rome, Italy, which was enrolled in a cross‐sectional survey on cholelithiasis. Participants were screened for the presence of gallstones by gallbladder ultrasonography, completed a questionnaire on family and personal history and underwent a physical examination and blood chemistry.

Russell H. Wiesner, Patricia Grambsch, Nicholas F. Larusso, E. Rolland Dickson – 1 July 1988 – The clinicopathologic features and natural history of primary sclerosing cholangitis were reviewed in 53 patients followed at the Yale Liver Center during the past 30 yr. At presentation, the mean age of patients was 46 yr, and the male to female ratio was 1.4:1. Biliary sclerosis was limited to the intrahepatic ductal system in 21% of the patients.

Margo A. Denke, Scott M. Grundy – 1 July 1988 – Bile acid binding resins are indicated for treatment of elevated plasma low‐density lipoprotein cholesterol concentrations. In normoglyceridemic patients, plasma concentrations of low‐density lipoprotein cholesterol and total cholesterol are closely linked, and for this reason resin treatment of elevated total cholesterol levels in these patients is rational and warranted. Hypertriglyceridemic patients may also have elevated total cholesterol concentrations, and several such patients have been treated with resin.

Herbert L. Bonkovsky – 1 July 1988

Anna S. F. Lok, Ching‐Lung Lai, Pui‐Chee Wu – 1 July 1988 – Of 1,801 Chinese subjects, age 1 to 90 years, screened for hepatitis B surface antigen and antibody (HBsAg, anti‐HBs) and antibody to hepatitis B core antigen (anti‐HBc), 214 (11.9%) had an isolated, positive anti‐HBc result; anti‐HBc was reproducibly present in the initial sera in only 66% and persisted after an interval of 2 weeks to 3 months in only 73%. There was a strong correlation between the rates of reproducibility and persistence of isolated anti‐HBc and the initial anti‐HBc titers.

Bruno Clément, Pierre‐Yves Rescan, Georges Baffet, Olivier Loréal, Dominique Lehry, Jean‐Pierre Campion, André Guillouzo – 1 July 1988 – Previous studies have shown that laminin is present in basement membranes in normal liver but failed to identify cellular sources. We have investigated the extracellular and intracellular distribution of laminin in normal rat and human liver, in fibrotic human liver and in primary hepatocyte cultures from both species by light and electron microscopy using the indirect immunoperoxidase technique.