Feedback regulation of bile acid synthesis in the rat by dietary vs. Intravenous cholate or taurocholate

Eduard F. Stange, Jürgen Scheibner, Christine Lutz, Hans Ditschuneit – 1 July 1988 – The regulation of bile acid synthesis was studied (i) in intact or colectomized rats receiving cholate or taurocholate as a dietary supplement and (ii) in experiments using chow‐fed animals with a graded intravenous or intraduodenal taurocholate infusion. After the 2‐week diet period a bile fistula was established and rates of taurocholate, tauromuricholate and taurochenodeoxy‐cholate secretion were quantitated by high‐performance liquid chromatography.

Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: Lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors

Sophie Roy, Gilles Pomier‐Layrargues, Roger F. Butterworth, P.‐Michel Huet – 1 July 1988 – It has been suggested, from studies of a rabbit model of fulminant hepatic failure, that hepatic encephalopathy might be related to an increase in brain γ‐aminobutyric acid uptake through a more permeable blood‐brain barrier, leading to an overactivity of brain γ‐aminobutyric acid‐mediated inhibitory neurotrans‐mission.

The effect of retinol on ito cell proliferation in vitro

Bernard H. Davis, Angelina Vucic – 1 July 1988 – Hepatic sinusoidal fat‐storing Ito cells are felt to represent the primary storage site for hepatic vitamin A and may be important collagen‐producing effector cells during hepatic fibrogenesis. The cirrhotic liver generally has a decreased vitamin A content with increased numbers of “transitional” myofibroblasts adjacent to developing fibrous bands. It has been suggested that Ito cells “transform” into these myofibroblasts.

Maintenance of remission in autoimmune chronic active hepatitis with azathioprine after corticosteroid withdrawal

Anthony J. Stellon, John J. Keating, Philip J. Johnson, Ian G. McFarlane, Roger Williams – 1 July 1988 – Forty‐seven patients with autoimmune chronic active hepatitis in remission on azathioprine and/or prednisolone were entered into a randomized controlled trial to assess the value of azathioprine alone in maintenance of remission.

Wilson's disease: Transplantation when all else has failed

Irmin Sternlieb – 1 July 1988 – Experience with liver transplantation for patients with Wilson's disease who have major neurological impairment is limited, and this report describes the results obtained in two such patients. The first was a 30‐year‐old man with a 14‐month history of hepatic and neurological impairment. In spite of treatment with d‐penicillamine, he developed increasing dysarthria, dysphagia, akinesia and rigidity of all four limbs, and required continuous nursing care.

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