Gabriel Garcia, F. Blaine Hollinger – 1 September 1988 – Hepatitis B virus (HBV) infection may induce severe hepatitis and affect long‐term survival of kidney transplant recipients. Persistent viral infection has been shown to occur despite the absence of usual serologic markers. The liver and serum HBV deoxyribonucleic acid (DNA) status of 90 patients were studied prospectively; recently transplanted patients, both hepatitis B virus surface antigen (HBsAg)‐positive and negative, with and without liver disease, were investigated with HBV serology, serum HBV DNA, and liver histology.

Adrian M. Di Bisceglie – 1 September 1988

1 September 1988

Eric Fréneaux, Gilles Labbe, Philippe Letteron, The Le Dinh, Claude Degott, Jean Genève, Dominique Larrey, Dominique Pessayre – 1 September 1988 – Intravenous administration of high doses of tetracycline may produce severe microvesicular steatosis of the liver in man. A similar disease is observed after ingestion of drugs which inhibit hepatic mitochondrial fatty acid β‐oxidation and in subjects with various inborn defects in this metabolic pathway. We therefore determined the effects of tetracycline on the mitochondrial oxidation of fatty acids in mice and in man.

1 September 1988

Eike Walter, Hubert E. Blum, Peter Meier, Martin Huonker, Martin Schmid, Klaus‐Peter Maier, Wolf‐Bernhard Offensperger, Silke Offensperger, Wolfgang Gerok – 1 July 1988 – Hepatocellular carcinoma tissues from HBsAg‐negative patients with chronic alcoholic liver disease were investigated for the presence of hepatitis B virus DNA. Southern blot analyses of DNA extracted from the hepatocellular carcinomas were negative for hepatitis B virus DNA in all 17 patients examined, at a level of sensitivity of less than 0.01 genome equivalent per cell.

Kenji Fujiwara, Itsuro Ogata, Yasuhiko Ohta, Shigeki Hayashi, Shunji Mishiro, Katsuyoshi Takatsuki, Yuzuru Sato, Shinwa Yamada, Keichi Hirata, Hiroshi Oka, Toshitsugu Oda, Hisanori Kawaji, Shinobu Matsuda, Yasuhiko Niiyama, Ryoichi Tsukuda – 1 July 1988 – Hepatic fibrosis was induced in rats by repeated i.p. injections of pig serum. The hepatic hydroxyproline content increased to 2.1 times the normal control level at 6 weeks and to 3.2 times at 10 weeks.

Jordi Camps, Xavier Sola, Antoni Rimola, Albert Parés, Antoni Rives, Juan M. Salmeron, Vicente Arroyo, Joan Rodés – 1 July 1988 – Several authors have suggested that the risk of developing aminoglycoside nephrotoxicity is greater in cirrhotic patients than in the noncirrhotic population. However, this has not been confirmed by other investigators. To compare the intensity and characteristics of aminoglycoside nephrotoxicity in cirrhotic and normal rats, 31 rats with carbon tetrachloride‐induced cirrhosis with ascites and 35 control rats were treated with gentamicin.

Roland Schachler, Tilman Sauerbruch, Ulrich Wosiewitz, Joseph Holl, Dietbert Hahn, Roland Denk, Michael Neubrand, Gustav Paumgartner – 1 July 1988 – Eighty in vitro experiments were performed with single (n = 51) or multiple (n = 29) gallstones in order to find out which parameters are of prime importance for their disintegration by extracorporeal shock waves. A Dornier lithotripter and an upper limit of 1,500 discharges were employed.

Ian R. Wanless – 1 July 1988