Eric Fréneaux, Gilles Labbe, Philippe Letteron, The Le Dinh, Claude Degott, Jean Genève, Dominique Larrey, Dominique Pessayre – 1 September 1988 – Intravenous administration of high doses of tetracycline may produce severe microvesicular steatosis of the liver in man. A similar disease is observed after ingestion of drugs which inhibit hepatic mitochondrial fatty acid β‐oxidation and in subjects with various inborn defects in this metabolic pathway. We therefore determined the effects of tetracycline on the mitochondrial oxidation of fatty acids in mice and in man.

1 September 1988

Eike Walter, Hubert E. Blum, Peter Meier, Martin Huonker, Martin Schmid, Klaus‐Peter Maier, Wolf‐Bernhard Offensperger, Silke Offensperger, Wolfgang Gerok – 1 July 1988 – Hepatocellular carcinoma tissues from HBsAg‐negative patients with chronic alcoholic liver disease were investigated for the presence of hepatitis B virus DNA. Southern blot analyses of DNA extracted from the hepatocellular carcinomas were negative for hepatitis B virus DNA in all 17 patients examined, at a level of sensitivity of less than 0.01 genome equivalent per cell.

Kenji Fujiwara, Itsuro Ogata, Yasuhiko Ohta, Shigeki Hayashi, Shunji Mishiro, Katsuyoshi Takatsuki, Yuzuru Sato, Shinwa Yamada, Keichi Hirata, Hiroshi Oka, Toshitsugu Oda, Hisanori Kawaji, Shinobu Matsuda, Yasuhiko Niiyama, Ryoichi Tsukuda – 1 July 1988 – Hepatic fibrosis was induced in rats by repeated i.p. injections of pig serum. The hepatic hydroxyproline content increased to 2.1 times the normal control level at 6 weeks and to 3.2 times at 10 weeks.

Jordi Camps, Xavier Sola, Antoni Rimola, Albert Parés, Antoni Rives, Juan M. Salmeron, Vicente Arroyo, Joan Rodés – 1 July 1988 – Several authors have suggested that the risk of developing aminoglycoside nephrotoxicity is greater in cirrhotic patients than in the noncirrhotic population. However, this has not been confirmed by other investigators. To compare the intensity and characteristics of aminoglycoside nephrotoxicity in cirrhotic and normal rats, 31 rats with carbon tetrachloride‐induced cirrhosis with ascites and 35 control rats were treated with gentamicin.

Roland Schachler, Tilman Sauerbruch, Ulrich Wosiewitz, Joseph Holl, Dietbert Hahn, Roland Denk, Michael Neubrand, Gustav Paumgartner – 1 July 1988 – Eighty in vitro experiments were performed with single (n = 51) or multiple (n = 29) gallstones in order to find out which parameters are of prime importance for their disintegration by extracorporeal shock waves. A Dornier lithotripter and an upper limit of 1,500 discharges were employed.

Ian R. Wanless – 1 July 1988

Toshikazu Uchida, Koyu Suzuki, Yasunori Okuda, Toshio Shikata – 1 July 1988 – An attempt was made to infect primary duck hepatocyte cultures with duck hepatitis B virus in vitro in order to clarify the biology of hepatitis B virus. Livers of ducklings, 0 to 17 days posthatch, without viremia were digested ex situ by perfusion of collagenase solution through the portal or hepatic vein.

Y. Peled, Z. Halpern, R. Baruch, G. Goldman, T. Gilat – 1 July 1988 – This study was performed to determine whether biliary cholesterol nucleates primarily from vesicles or micelles. Twenty gallbladder biles and 12 hepatic biles from patients with gallstones as well as 16 model biles were examined. The nucleation times (days) of the biles as well as their isolated vesicular and micellar fractions were determined and their lipid composition was analyzed. In 41 of 46 comparisons, cholesterol nucleated faster from vesicles than micelles; in only one case was the opposite found.

Willis C. Maddrey, David H. Van Thiel – 1 July 1988