Affinities and densities of high‐affinity [3H]muscimol (GABA‐A) binding sites and of central benzodiazepine receptors are unchanged in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

Roger F. Butterworth, Joël Lavoie, Jean‐François Giguère, Gilles Pomier‐Layrargues – 1 September 1988 – The integrity of GABA‐A receptors and of central benzodiazepine receptors was evaluated in membrane preparations from prefrontal cortex and caudate nuclei obtained at autopsy from nine cirrhotic patients who died in hepatic coma and an equal number of age‐matched control subjects. Histopathological studies revealed Alzheimer Type II astrocytosis in all cases in the cirrhotic group; controls were free from neurological, psychiatric or hepatic diseases.

Assessment of hepatic encephalopathy with visual evoked potentials compared with conventional methods

Neville L. Sandford, Ronald E. Saul – 1 September 1988 – Thirty‐six patients with advanced chronic liver disease of predominantly alcoholic etiology and with a documented history or current physical evidence of hepatic encephalopathy were studied and compared to 30 healthy controls. Assessment was made of their mental state, number connection test, venous blood ammonia, electroencephalography and visual evoked potentials with both pattern reversal and flash stimuli.

A rat strain that spontaneously develops severe hepatic necrosis and later hepatocellular carcinoma

Kunio Okuda – 1 September 1988 – A new mutant causing hereditary hepatitis associated with severe jaundice has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal necrosis of enlarged hepatocytes without inflammatory cell response.

Hepatitis D virus RNA in acute delta infection: Serological profile and correlation with other markers of hepatitis D virus infection

Maria Buti, Rafael Esteban, Michael Roggendorf, Juan Fernandez, Rosendo Jardi, Rudolf Rashofer, Helena Allende, Juan Genesca, Juan Ignacio Esteban, Jaime Guardia – 1 September 1988 – To evaluate the profile of hepatitis D virus replication and the corresponding immunoresponse after acute hepatitis D virus infection, sera from 50 patients with acute hepatitis D (36 with acute hepatitis B virus‐hepatitis D virus coinfection and 14 HBsAg carriers with hepatitis D virus superinfection) were investigated for the presence of hepatitis D virus RNA and other serological hepatitis D virus markers.

Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease

Mukunda B. Ray, Charles L. Mendenhall, Samuel W. French, Peter S. Gartside, The Veterans Administration Cooperative Study Group – 1 September 1988 – The clinical and histologic significance of cytokeratin antigen expression in various intrahepatic locations was assessed in 57 patients with alcoholic liver disease as part of a large Veterans Administration Cooperative Study of Alcoholic Hepatitis.

Deficiency of protein C in patients with portal vein thrombosis

Hector Orozco, Edmundo Guraieb, Takeshi Takahashi, Guadalupe Garcia‐Tsao, Rafael Hurtado, Roger Anaya, Guillermo Ruiz‐Arguelles, Jorge Hernandez‐Ortiz, Marco A. Casillas, Luis Guevara – 1 September 1988 – Portal vein thrombosis has been considered idiopathic in 50% of cases reported in adults. Protein C deficiency is a recently described disorder characterized by a predisposition to develop thromboembolic disease.

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