Hastings K. Wright – 1 November 1988

Geoffrey M. Dusheiko – 1 November 1988 – In a previous study a partial inhibition of viral replication was observed in HBeAg‐positive patients after acyclovir (ACV) treatment.

Antonio Ponzetto, Francesco Negro, Hans Popper, Ferruccio Bonino, Ronald Engle, Mario Rizzetto, Robert H. Purcell, John L. Gerin – 1 November 1988 – Five consecutive passages of hepatitis delta virus in hepatitis B virus carrier chimpanzees were performed in order to further characterize the infectious and pathogenic nature of this naturally occurring defective virus. Three animals received identical inocula at fourth passage in order to assess individual animal variation as a factor in the course of infection and disease.

Kwang‐Juei Lo, Shou‐Dong Lee, Yang‐Te Tsai, Tzee‐Chung Wu, Cho‐Yu Chan, Gran‐Hum Chen, Ching‐Lan Yeh – 1 November 1988 – In an attempt to evaluate the long‐term immunogenicity and efficacy of plasma‐derived hepatitis B vaccine in preventing hepatitis B virus infection, 199 infants born to hepatitis B e antigen‐positive hepatitis B surface antigen‐carrier mothers were found to be antibody to HBsAg‐positive (± 10 mIU per ml) 2 months after the first booster of hepatitis B vaccination at age 1, and their serum HBsAg and anti‐HBs were rechecked annually to ages 3 to 5.

Richard J. Havel, Robert L. Hamilton – 1 November 1988

Katsunori Wada, Fukuo Kondo, Yoichiro Kondo – 1 November 1988 – In order to reveal the precursor lesion of hepatocellular carcinoma, a histopathologic study was performed on 141 cases of liver cirrhosis with or without hepatocellular carcinoma. Exclusive of primary or metastatic hepatocellular carcinoma nodules, 94 nodular lesions (>5 mm) were detected in 53 cirrhotic livers. They consisted of 83 large regenerative nodules and 11 dysplastic nodules.

Henry C. Bodenheimer, Ronald A. Faris, Colette Charland, Douglas C. Hixson – 1 November 1988 – We have characterized the cell and tissue binding specificity of a newly generated monoclonal antibody, Mab Ku‐1, which shows selective reactivity with rat macrophages and Kupffer cells. The hybridoma secreting Mab Ku‐1 was constructed by fusion of 8653 myeloma cells with spleen cells isolated from a mouse immunized with nonparenchymal liver cells coated with antihepatocyte antibodies.

Peter Van Eyken, Raf Sciot, Francesco Callea, Kris Van Der Steen, Philip Moerman, Valeer J. Desmet – 1 November 1988 – The development of the intrahepatic bile ducts in man was studied using an immunohistochemical technique on 56 liver specimens ranging in age from 6 weeks of gestation to 8 months after birth. On paraffin sections, two monoclonal anticytokeratin antibodies (CAM 5.2 and KL‐1) that normally stain both hepatocytes and bile duct cells and two polyclonal anticytokeratin antisera that in normal adult liver stain bile ducts only were applied.

John M. Porter, Marc S. Sussman, Gerald M. Rosen – 1 November 1988 – A patient with hepatonecrosis associated with cocaine use is presented. Postmortem examination of the liver showed marked periportal inflammation and necrosis, and mild diffuse fatty infiltration. These pathologic findings are identical to those previously reported in a mouse model of cocaine hepatotoxicity.

Harry A. Cynamon, Karyl Norcross, J. Nevin Isenberg – 1 November 1988 – To assess the effect of chronic cholestasis and vitamin E deficiency on nervous system function, we did multimodality evoked potential testing of 17 children (mean age = 47 months) who had chronic liver disease. Evoked potential testing was repeated periodically in 11 patients 1 to 33 months after the initial study.