John M. Porter, Marc S. Sussman, Gerald M. Rosen – 1 November 1988 – A patient with hepatonecrosis associated with cocaine use is presented. Postmortem examination of the liver showed marked periportal inflammation and necrosis, and mild diffuse fatty infiltration. These pathologic findings are identical to those previously reported in a mouse model of cocaine hepatotoxicity.

Harry A. Cynamon, Karyl Norcross, J. Nevin Isenberg – 1 November 1988 – To assess the effect of chronic cholestasis and vitamin E deficiency on nervous system function, we did multimodality evoked potential testing of 17 children (mean age = 47 months) who had chronic liver disease. Evoked potential testing was repeated periodically in 11 patients 1 to 33 months after the initial study.

David H. Adams, David Burnett, Robert A. Stockley, Stefan G. Hubscher, Paul McMaster, Elwyn Elias – 1 November 1988 – β2‐Microglobulin, which is associated with HLA class 1 antigens, was assayed in bile and serum from 19 patients following 22 liver transplants. Serum levels were elevated in all posttransplant patients irrespective of the presence of rejection. In contrast, biliary levels were significantly higher during episodes of acute rejection compared with posttransplant cholangitis (p < 0.01), stable graft function (p < 0.0001) and nontrans‐plant samples (p < 0.0001).

Toru Nakano, Jiro Yanagisawa, Fumio Nakayama – 1 November 1988 – To investigate the importance of bacterial infection in the formation of free fatty acids found in brown pigment gallstones, free fatty acids and phospholipase activity in hepatic bile, with or without the presence of bacterial infection, were compared. The concentration of free fatty acids in bile with bacterial infection [0.467 ± 0.447 mg per ml (mean ± S.D.)] was significantly higher than when bacterial infection was absent (0.073 ± 0.041 mg per ml; p < 0.01).

1 November 1988

1 September 1988

Eric Fréneaux, Gilles Labbe, Philippe Letteron, The Le Dinh, Claude Degott, Jean Genève, Dominique Larrey, Dominique Pessayre – 1 September 1988 – Intravenous administration of high doses of tetracycline may produce severe microvesicular steatosis of the liver in man. A similar disease is observed after ingestion of drugs which inhibit hepatic mitochondrial fatty acid β‐oxidation and in subjects with various inborn defects in this metabolic pathway. We therefore determined the effects of tetracycline on the mitochondrial oxidation of fatty acids in mice and in man.

1 September 1988

Adrian M. Di Bisceglie – 1 September 1988

Gabriel Garcia, F. Blaine Hollinger – 1 September 1988 – Hepatitis B virus (HBV) infection may induce severe hepatitis and affect long‐term survival of kidney transplant recipients. Persistent viral infection has been shown to occur despite the absence of usual serologic markers. The liver and serum HBV deoxyribonucleic acid (DNA) status of 90 patients were studied prospectively; recently transplanted patients, both hepatitis B virus surface antigen (HBsAg)‐positive and negative, with and without liver disease, were investigated with HBV serology, serum HBV DNA, and liver histology.