The use of a monoclonal antibody against α‐fetoprotein for the radioimmunodetection of hepatocellular carcinoma

Elsa Springolo, Michael C. Kew, Jan Esser, Margaretha Beyers, Jan D. Conradie, Joseph Levin – 1 January 1989 – The purpose of this study was to investigate the use of a radiolabeled mouse monoclonal antibody (and its F(ab′)2 fragment) against α‐fetoprotein in the scinti‐graphic diagnosis of hepatocellular carcinoma. Twenty‐six southern African Blacks and one Caucasian with hepatocellular carcinoma and four patients with other malignant tumors of the liver were studied.

Technetium‐99m‐iminodiacetic acid organic anions: Review of biokinetics and clinical application in hepatology

Shakuntala Krishnamurthy, Gerbail T. Krishnamurthy – 1 January 1989 – Technetium‐99m‐labeled iminodiacetic acid analogs are a new class of organic anions, taken up and secreted by hepatocyte into hepatic bile by a carrier‐mediated organic anion pathway. They provide a new dimension in the assessment of pathophysiology and morphology of the hepatobiliary system. The amount of uptake and the rapidity of its elimination from the liver is dependent upon the structural configuration of the agent as well as the functional integrity of the hepatocyte and the patency of the biliary system.

Metoprolol‐induced hepatitis: Is the rate of oxidation related to drug‐induced hepatotoxicity?

M. S. Lennard – 1 January 1989 – Metoprolol is as widely used beta‐adrenoreceptor antagonist. There is no report of hepatitis involving this drug as well as other beta‐adrenoreceptor antagonists. Metoprolol is metabolized by three major oxidation pathways. Two of them, Odealkylation and alpha‐hydroxylation, undergo genetically controlled polymorphisms correlated with that of debrisoquine oxidation.

Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA clone of branched‐chain α‐keto acid dehydrogenase dihydrolipoamide acyltransferase, the 52 kD mitochondrial autoantigen

Charles D. Surh, Dean J. Danner, Aftab Ahmed, Ross L. Coppel, Ian R. Mackay, E. Rolland Dickson, M. Eric Gershwin – 1 January 1989 – Antimitochondrial autoantibodies recognizing 68 to 74 and 50 to 52 kD inner membrane mitochondrial antigens are characteristically present in sera of patients with primary biliary cirrhosis. The biochemical identification of the antigens, however, has remained elusive. We report herein that the 52 kD antigen is the dihydrolipoamide acyltransferase of the branched‐chain α‐keto acid dehydrogenase complex.

Interferon‐associated lymphocyte 2′,5′‐oligoadenylate synthetase in acute and chronic viral hepatitis

Jenny Heathcote, Young‐In Kim, Colina K. Yim, James Lebrocq, Stanley E. Read – 1 January 1989 – Basal levels of the interferon‐associated enzyme 2′,5′‐oligoadenylate synthetase were studied in lymphocytes of 46 patients with acute viral hepatitis and in 46 patients with chronic hepatitis B. Measurement of in vitro production of 2′,5′‐oligoadenylate synthetase following overnight incubation of lymphocytes with exogenous interferon was used to assess functional capacity of the lymphocyte interferon system.

α‐fetoprotein monitoring in chinese patients with chronic hepatitis B virus infection: Role in the early detection of hepatocellular carcinoma

Anna S. F. Lok, Ching‐Lung Lai – 1 January 1989 – Two hundred ninety patients (203 men, 87 women), age 7 to 74 years (mean: 39.1 years), with chronic hepatitis B virus infection, were prospectively followed for a period of 1 to 4 years to determine the value of α‐fetoprotein monitoring in the early detection of hepatocellular carcinoma. At presentation, 66% of the patients were asymptomatic, 19% had chronic hepatitis and 15% had established cirrhosis.

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