Microvascular abnormalities of the portal hypertensive gastric mucosa

Andrzej S. Tarnawski, I. James Sarfeh, Jerzy Stachura, Andrew Hajduczek, Hai X. Bui, Wojciech Dabros, Hella Gergely – 1 November 1988 – Compared with normotensive mucosa, the portal hypertensive gastric mucosa has increased susceptibility to injury by noxious agents such as alcohol and aspirin, but the mechanism of this phenomenon is unclear.

Hepatic innervation in hepatic regeneration

Jennifer L. Cruise – 1 November 1988 – The autonomic nervous system in rats has been assessed by means of indirect immunofluorescence using monospecific antibodies to neuron‐specific enolase, neurofilaments, glial fibrillary acidic protein and S‐100 protein [10 days after partial (70%) hepatectomy]. Different groups of rats were studied: group A: 70% resection and normal dual blood supply (n = 5);group B: 70% resection with only portal blood to the liver remnant (n = 5);group C: 70% resection with only arterial blood to the liver remnant (n = 5);group D: sham operated controls (n = 5).

Relative risks of death due to liver disease among Japanese male adults having various statuses for hepatitis B s and e antigen/antibody in serum: A prospective study

Koshi Sakuma, Nobuteru Saitoh, Misako Kasai, Hiroshi Jitsukawa, Izumi Yoshino, Momoko Yamaguchi, Kouichi Nobutomo, Makoto Yamumi, Fumio Tsuda, Tsutomu Komazawa, Tetsuo Nakamura, Yasuo Yoshida, Kunio Okuda – 1 November 1988 – Taking advantage of the compulsory annual medical check‐up at the Central Institute of Health, Japan National Railways, hepatitis B seromarkers were tested in male employees at work and their “dead and alive” status was followed for more than 6 years for their prognostic significance. Two prospective studies were carried out.

Hepatic zinc content in patients with various stages of alcoholic liver disease and in patients with chronic active and chronic persistent hepatitis

Johann Christian Bode, Peter Hanisch, Harald Henning, Wolfgang Koenig, Friedrich‐Wilhelm Richter, Christiane Bode – 1 November 1988 – The hepatic zinc content was determined in liver biopsies of patients with alcoholic and nonalcoholic liver disease using proton‐induced X‐ray emission. The values obtained in postmortem specimens of the liver from 27 patients with no evidence of acute or chronic liver disease served as controls. The mean value and the range of the zinc content in the controls (75 ± 24 ppm wet weight) are in good agreement with those reported in the literature.

23‐Methyl‐3α, 7β‐dihydroxy‐5β‐cholan‐24‐oic acid: Dose‐response study of biliary secretion in rat

Aldo Roda, Rita Aldini, Brunella Grigolo, Patrizia Simoni, Enrico Roda, Roberto Pellicciari, Pier Luigi Lenzi, Benedetto Natalini – 1 November 1988 – A side chain derivative of ursodeoxycholic acid, 23‐methylursodeoxycholic acid, was synthesized and the effect of i.v. infusion of the acid at different doses (0.75, 1.5, 3.0 and 6.0 μmoles per min per kg body weight over 1 hr) on bile flow, on its hepatic biotransformations and on biliary lipid secretion has been studied in bile fistula rats.

Distal splenorenal vs. portal‐systemic shunts after hemorrhage from varices: A randomized controlled trial

Norman D. Grace, Harold O. Conn, Robert H. Resnick, Roberto J. Groszmann, Colin E. Atterbury, Stephen C. Wright, Richard J. Gusberg, Rudolph Vollman, Guadalupe Garcia‐Tsao, Rosemarie L. Fisher, Edward T. O'Hara, William V. McDermott, J. Peter Maselli, Warren Widrich, Daniel S. Matloff, Douglas Horst, Naomi Banks, Jeanne Alberts – 1 November 1988 – Between 1975 and 1983, 303 cirrhotic patients with endoscopically proven major variceal hemorrhage were admitted to the participating hospitals of the Boston‐New Haven Collaborative Liver Group.

Long‐term follow‐up of anti‐HBe‐positive chronic active hepatitis B

Giovanna Fattovich, Lucio Brollo, Alfredo Alberti, Patrizia Pontisso, Giuliano Giustina, Giuseppe Realdi – 1 November 1988 – Twenty‐eight patients with chronic active hepatitis without cirrhosis who were positive for hepatitis B surface antigen and antibody to hepatitis B e antigen were followed for 1 to 15 years (mean 6.6 years) and underwent follow‐up biopsy.

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