Jurgen Ludwig, Chung H. Kim, Russell H. Wiesner, Ruud A. F. Krom – 1 February 1989 – A 43‐year‐old man underwent abdominoperineal resection of a rectal adenocarcinoma, and left hepatic lobectomy for a single metastasis. He then received hepatic artery infusions of floxuridine. The tumor did not recur, but sclerosing cholangitis and liver failure developed which necessitated orthotopic liver transplantation. In the hilus of the native liver, obstructive arteriopathy and portal venopathy were found. These lesions probably had been caused by drug‐induced intravascular thrombosis.

Ricardo Mastaï, Bernard Rocheleau, P. ‐Michel Huet – 1 February 1989 – It has recently been reported that the administration of ketanserin, a serotonin antagonist, was associated with a significant reduction in portal pressure both in portal hypertensive rats and cirrhotic patients. However, this beneficial effect on splanchnic hemodynamics was accompanied by a significant reduction in arterial pressure.

1 February 1989

Shiro Oguma, Steven Belle, Thomas E. Starzl, A. Jake Demetris – 1 February 1989 – Conspicuous pathologic features of chronic liver allograft rejection include bile duct loss and chronic obliterative arteriopathy. A quantitative histometric analysis was performed to document the extent of bile duct loss, the size of the “vanished” ducts and the extent of chronic obliterative arteriopathy and to determine whether there was any relationship between chronic obliterative arteriopathy and bile duct loss.

Renee C. Lin, Lawrence Lumeng, Vickie L. Phelps – 1 February 1989 – Effects of chronic ethanol consumption on serum lip–oproteins have been studied in the rat. The serum levels of triglycerides, cholesterol, phospholipids and apolipo‐proteins AI and AIV increased significantly after 1 week of ethanol feeding, and they remained elevated up to 7 weeks of alcohol drinking. By contrast, serum total apolipoprotein E decreased or, sometimes, did not change.

Lawrence I. Deckelbaum – 1 February 1989 – Three cases of hepatic inferior vena cava (IVC) obstruction (two segmental and one membranous) associated with Budd‐Chiari syndrome were successfully treated with percutaneous transluminal angioplasty (PTA) with use of an Nd‐YAG (neodymium‐yttrium, aluminum, garnet) laser. The occluded portions were canalized by advancing a ceramic‐capped delivery system and delivering intermittent laser emissions. The canal was widened by simultaneous inflation of three or four Gruentzig balloon catheters.

Antoine Hadengue, Richard Moreau, Raimondo Cerini, Abraham Koshy, Samuel S. Lee, Didier Lebrec – 1 January 1989 – Drugs reported to reduce portal pressure through different mechanisms were combined in the hope of either additive portal hypotensive effects in “responders,” or inducing a portal hypotensive effect in “nonresponders” to the initial drug. Seven patients with alcoholic cirrhosis received verapamil, 10 mg i.v., and, 60 min later, ketanserin, 5 mg i.v.

Michael C. Kew, Ann McKnight, John Hodkinson, Stanley Bukofzer, Jan D. Esser – 1 January 1989 – Membranous obstruction of the inferior vena cava has been incriminated as a risk factor for hepatocellular carcinoma in South African Blacks and in Japanese. However, the frequency with which this anomaly is found in patients with hepatocellular carcinoma, and hence its numerical importance as an etiological association of the tumor, has not been ascertained.

David H. Van Thiel, Judith S. Gavaler – 1 January 1989 – In elderly males hormonal changes occur that are believed to cause benign prostatic hyperplasia (BPH). These are decreased testosterone production, an increased testosterone SHBG and a slightly increased estradiol production. Liver cirrhosis in males causes similar endocrine changes. We carried out a post mortem study evaluating the prostates of 51 men who died with liver cirrhosis compared with a similar group without any hepatic disease.

Kenneth W. Warren – 1 January 1989