Koshi Sakuma, Nobuteru Saitoh, Misako Kasai, Hiroshi Jitsukawa, Izumi Yoshino, Momoko Yamaguchi, Kouichi Nobutomo, Makoto Yamumi, Fumio Tsuda, Tsutomu Komazawa, Tetsuo Nakamura, Yasuo Yoshida, Kunio Okuda – 1 November 1988 – Taking advantage of the compulsory annual medical check‐up at the Central Institute of Health, Japan National Railways, hepatitis B seromarkers were tested in male employees at work and their “dead and alive” status was followed for more than 6 years for their prognostic significance. Two prospective studies were carried out.

Johann Christian Bode, Peter Hanisch, Harald Henning, Wolfgang Koenig, Friedrich‐Wilhelm Richter, Christiane Bode – 1 November 1988 – The hepatic zinc content was determined in liver biopsies of patients with alcoholic and nonalcoholic liver disease using proton‐induced X‐ray emission. The values obtained in postmortem specimens of the liver from 27 patients with no evidence of acute or chronic liver disease served as controls. The mean value and the range of the zinc content in the controls (75 ± 24 ppm wet weight) are in good agreement with those reported in the literature.

Aldo Roda, Rita Aldini, Brunella Grigolo, Patrizia Simoni, Enrico Roda, Roberto Pellicciari, Pier Luigi Lenzi, Benedetto Natalini – 1 November 1988 – A side chain derivative of ursodeoxycholic acid, 23‐methylursodeoxycholic acid, was synthesized and the effect of i.v. infusion of the acid at different doses (0.75, 1.5, 3.0 and 6.0 μmoles per min per kg body weight over 1 hr) on bile flow, on its hepatic biotransformations and on biliary lipid secretion has been studied in bile fistula rats.

Norman D. Grace, Harold O. Conn, Robert H. Resnick, Roberto J. Groszmann, Colin E. Atterbury, Stephen C. Wright, Richard J. Gusberg, Rudolph Vollman, Guadalupe Garcia‐Tsao, Rosemarie L. Fisher, Edward T. O'Hara, William V. McDermott, J. Peter Maselli, Warren Widrich, Daniel S. Matloff, Douglas Horst, Naomi Banks, Jeanne Alberts – 1 November 1988 – Between 1975 and 1983, 303 cirrhotic patients with endoscopically proven major variceal hemorrhage were admitted to the participating hospitals of the Boston‐New Haven Collaborative Liver Group.

Claudio Tiribelli – 1 November 1988

Roberto J. Groszmann, Luis A. Colombato – 1 November 1988

Giovanna Fattovich, Lucio Brollo, Alfredo Alberti, Patrizia Pontisso, Giuliano Giustina, Giuseppe Realdi – 1 November 1988 – Twenty‐eight patients with chronic active hepatitis without cirrhosis who were positive for hepatitis B surface antigen and antibody to hepatitis B e antigen were followed for 1 to 15 years (mean 6.6 years) and underwent follow‐up biopsy.

J. Gerald Kenna, James Neuberger, Roger Williams – 1 November 1988 – Previous investigations have shown that antibodies in sera from patients with halothane hepatitis recognize neoantigens, expressed in livers of halothane‐exposed rabbits and rats, which consist of a halothane metabolite bound covalently to specific microsomal proteins. These studies have suggested that the patients' antibodies may play a role in the pathogenesis of the hepatitis.

Victor Plourde, Marielle Gascon‐Barré, Bernard Willems, P.‐Michel Huet – 1 November 1988 – The role of the liver as a contributory factor in the vitamin D deficiency of cholestatic liver disease has been studied in vivo in dogs with chronic bile duct ligation, whereas controls underwent diversion of the bile flow through the urinary bladder via a choledococystostomy anastomosis.

Eben S. Fox, Peter Thomas, Selwyn A. Broitman – 1 November 1988 – While it is generally believed that hepatic clearance of lipopolysaccharide involves Kupffer cells, the mechanism involved has not been fully elucidated. This study assesses this phenomenon in terms of in vitro uptake and post‐uptake modification experiments with an 125I‐labeled Salmonella minnesota lipopolysaccharide. 125I‐Lipopolysaccharide was added to Kupffer cells in suspension cultures under a variety of conditions. In vitro uptake of 125I‐Lipopolysaccharide was not saturable up to concentrations of 33.33 μg per ml.