Neville L. Sandford, Ronald E. Saul – 1 September 1988 – Thirty‐six patients with advanced chronic liver disease of predominantly alcoholic etiology and with a documented history or current physical evidence of hepatic encephalopathy were studied and compared to 30 healthy controls. Assessment was made of their mental state, number connection test, venous blood ammonia, electroencephalography and visual evoked potentials with both pattern reversal and flash stimuli.

Kunio Okuda – 1 September 1988 – A new mutant causing hereditary hepatitis associated with severe jaundice has been discovered in the LEC strain of rats. Hepatitis appears suddenly in adult rats three to four months after birth. The clinical signs of hepatitis are characterized by severe jaundice, subcutaneous bleeding, oliguria, and loss of body weight. The affected rats showed a high lethality and histological changes of the liver with focal necrosis of enlarged hepatocytes without inflammatory cell response.

Marc I. Lorber – 1 September 1988

1 September 1988

Maria Buti, Rafael Esteban, Michael Roggendorf, Juan Fernandez, Rosendo Jardi, Rudolf Rashofer, Helena Allende, Juan Genesca, Juan Ignacio Esteban, Jaime Guardia – 1 September 1988 – To evaluate the profile of hepatitis D virus replication and the corresponding immunoresponse after acute hepatitis D virus infection, sera from 50 patients with acute hepatitis D (36 with acute hepatitis B virus‐hepatitis D virus coinfection and 14 HBsAg carriers with hepatitis D virus superinfection) were investigated for the presence of hepatitis D virus RNA and other serological hepatitis D virus markers.

Sangkot Marzuki, Ian R. Mackay, Herawati Sudoyo, A. Saifuddin Noer – 1 September 1988

1 September 1988

Mukunda B. Ray, Charles L. Mendenhall, Samuel W. French, Peter S. Gartside, The Veterans Administration Cooperative Study Group – 1 September 1988 – The clinical and histologic significance of cytokeratin antigen expression in various intrahepatic locations was assessed in 57 patients with alcoholic liver disease as part of a large Veterans Administration Cooperative Study of Alcoholic Hepatitis.

Hector Orozco, Edmundo Guraieb, Takeshi Takahashi, Guadalupe Garcia‐Tsao, Rafael Hurtado, Roger Anaya, Guillermo Ruiz‐Arguelles, Jorge Hernandez‐Ortiz, Marco A. Casillas, Luis Guevara – 1 September 1988 – Portal vein thrombosis has been considered idiopathic in 50% of cases reported in adults. Protein C deficiency is a recently described disorder characterized by a predisposition to develop thromboembolic disease.

Pete A. Poole, William C. Duane – 1 September 1988 – In man bile acid synthesis has a distinct circadian rhythm but the relationship of this rhythm to feedback inhibition by bile acid is unknown. We measured bile acid synthesis as release of 14CO2 from [26‐14C]Cholesterol every 2 hr in three normal volunteers during five separate 24‐hr periods. Data were fitted by computer to a cosine curve to estimate amplitude and acrophase of the circadian rhythm. In an additional six volunteers, we measured synthesis every 2 hr from 8:00 a.m. to 4:00 p.m. only.