David H. Van Thiel, Judith S. Gavaler – 1 January 1989 – In elderly males hormonal changes occur that are believed to cause benign prostatic hyperplasia (BPH). These are decreased testosterone production, an increased testosterone SHBG and a slightly increased estradiol production. Liver cirrhosis in males causes similar endocrine changes. We carried out a post mortem study evaluating the prostates of 51 men who died with liver cirrhosis compared with a similar group without any hepatic disease.

Michael C. Kew, Ann McKnight, John Hodkinson, Stanley Bukofzer, Jan D. Esser – 1 January 1989 – Membranous obstruction of the inferior vena cava has been incriminated as a risk factor for hepatocellular carcinoma in South African Blacks and in Japanese. However, the frequency with which this anomaly is found in patients with hepatocellular carcinoma, and hence its numerical importance as an etiological association of the tumor, has not been ascertained.

Antoine Hadengue, Richard Moreau, Raimondo Cerini, Abraham Koshy, Samuel S. Lee, Didier Lebrec – 1 January 1989 – Drugs reported to reduce portal pressure through different mechanisms were combined in the hope of either additive portal hypotensive effects in “responders,” or inducing a portal hypotensive effect in “nonresponders” to the initial drug. Seven patients with alcoholic cirrhosis received verapamil, 10 mg i.v., and, 60 min later, ketanserin, 5 mg i.v.

Peter Schauder – 1 November 1988 – The effects of branched‐chain α‐ketoacids on flux through and activity state of the branched‐chain α‐ketoacid dehydrogenase complex were studied in hepatocytes prepared from chow‐fed, starved, and low‐protein‐diet‐fed rats. Very low concentrations of α‐ketoisocaproate caused a dramatic stimulation (50% activation at 20 μM) of α‐ketoisovalerate decarboxylation in hepatocytes from low‐protein‐fed rats. α‐Keto‐β‐methylvalerate was also effective, but less so than α‐ketoisocaproate.

Yolanta Kruszynska, Nicholas Williams, Michael Perry, Philip Home – 1 November 1988 – We have examined the hypothesis that insulin insensitivity in hepatic cirrhosis is related to abnormalities of glycogen deposition and skeletal muscle enzyme activities. Otherwise well patients with biopsy‐proven hepatic cirrhosis secondary to previous excess alcohol intake were studied.

Keith D. Lindor, Russell H. Wiesner, E. Rolland Dickson, Henry A. Homburger – 1 November 1988 – Blastogenesis of autoreactive T lymphocytes in the autologous mixed lymphocyte reaction has been shown to be decreased in patients with primary biliary cirrhosis, but the mechanisms underlying this abnormality are not known.

1 November 1988

Giacomo Laffi, Fabio Cominelli, Marco Ruggiero, Sandra Fedi, Vincenzo P. Chiarugi, Giorgio La Villa, Massimo Pinzani, Paolo Gentilini – 1 November 1988 – Hemorrhagic disorders are common in patients with liver cirrhosis and result from several factors including impaired platelet function. We evaluated platelet aggregation and arachidonic acid metabolism in response to standard agonists in platelet‐rich plasma from 12 cirrhotic patients with mild impairment of liver function (Child A), 12 patients with severe liver dysfunction (Child B and C) and 12 healthy subjects.

Carol A. Sattler, Norimasa Sawada, Gerald L. Sattler, Henry C. Pitot – 1 November 1988 – Primary cultures of adult rat hepatocytes in a serum‐free medium were observed by time lapse cinematography to proceed through mitotis and cytokinesis. An ultrastructural study of these cultures is presented with electron micrographs of each stage of mitosis and cytokinesis. The cultured hepatocytes begin to enter prophase about 48 hr after plating and proceed through mitosis in approximately 70 min not including cytokinesis.

Gilles Pomier‐Layrargues, Pierre‐Michel Huet, Claire Infante‐Rivard, Jean‐Pierre Villeneuve, Denis Marleau, Lester Duguay, Serge Tanguay, Pierre Lavoie – 1 November 1988 – The objective of this study was to assess the prognostic value of spontaneous portosystemic shunting and liver function for survival and spontaneous hepatic encephalopathy after end‐to‐side portacaval shunt in cirrhotic patients. One hundred ninety‐eight patients with variceal hemorrhage as shown by endoscopy were evaluated.