Joachim Limmer, Wolfgang E. Fleig, Dorothea Leupold, Reinhard Bittner, Hans Ditschuneit, Hans‐Günter Berger – 1 May 1988 – Patients suffering from Type I glycogen storage disease frequently develop hepatic tumors. Some of these were classified as carcinoma, with the majority of tumors representing benign adenomata. However, no evidence exists of malignant transformation of adenomata in these patients.
Jen‐Yang Chen, Tim J. Harrison, Chue‐Shue Lee, Ding‐Shinn Chen, Arie J. Zuckerman – 1 May 1988 – We have previously reported an analysis of DNA extracted from 31 primary liver tumors where, in 25 cases, we found chromosomal integration of hepatitis B virus DNA sequences. We describe here an investigation of the extent of the viral genome at each integration site in 15 of the hepatitis B virus DNA‐positive tumors using subgenomic fragments of the viral genome as probes.
Min Chan Lai, Myron J. Tong, Marek J. Nowicki, Shou‐Dong Lee – 1 May 1988 – Seventy HBsAg‐positive patients, including 24 with primary hepatocellular carcinoma, 34 with chronic active hepatitis, 12 with chronic persistent hepatitis and 30 asymptomatic healthy hepatitis B virus carriers were tested for anti‐HBc IgM using the Corzyme‐M test. Anti‐HBc IgM was detected in 50% of the primary hepatocellular carcinoma patients, 26.5% of the chronic active hepatitis patients, 25% of the chronic persistent hepatitis patients, but in none of the healthy hepatitis B virus carriers.
Michael Phillips, Laurence M. Cummins – 1 May 1988 – Recent studies have demonstrated that commercial preparations of hepatitis B immune globulin often contain antibody to the human immunodeficiency virus. The presence of this antibody has aroused concerns that treatment with hepatitis B immune globulin might passively induce human immunodeficiency virus antibody seropositivity, leading to incorrect diagnoses of human immunodeficiency virus exposure.
Susumu Ito, Yasuhiro Tsuji, Naoyuki Kitagawa, Ishihara Akihiko, Jyoji Syundo, Yoshiyuki Tamura, Seiichiro Kishi, Hiroyoshi Mori – 1 March 1988 – We adopted an automated method for measuring guanase in donor blood and examined the incidence of posttransfusional non‐A, non‐B hepatitis when donor blood with high guanase activities was excluded. Sixty‐seven (2.4%) of 2,826 units were excluded from use in transfusion because they had guanase activities above 1.71 units per liter. Of 112 recipients, 8 (7%) developed posttransfusional non‐A, non‐B hepatitis.
Hey‐Chi Hsu, Yon‐Ho Lin, Mei‐Hwei Chang, Ih‐Jen Su, Ding‐Shinn Chen – 1 March 1988 – The clinical, virologic and pathologic features of chronic hepatitis B virus infection were studied in 66 children, of whom 29 were symptomatic and 37 asymptomatic. The majority (79%) of symptomatic children had histologically aggressive diseases: 11 had chronic active hepatitis and 10 had cirrhosis. In contrast, most asymptomatic children had nonaggressive diseases (35 cases); only 2 had chronic active hepatitis.
Albert K. Groen, Jan P. J. Stout, Jan A. G. Drapers, Frans J. Hoek, Rob Grijm, Guido N. J. Tytgat – 1 March 1988 – Nucleation‐influencing activity was determined in T‐tube bile samples derived from patients with obstructive jaundice. Since native T‐tube bile samples do not nucleate, nucleation‐influencing activity was determined by measuring the influence of T‐tube bile on the nucleation time of model bile.
Jin Zhihong, Zhao Guolong, Xiong Shisong, Kou Pingyuan, Ma Lili, Chen Hongtao, Qi Jianying, Ba Qiuju, Mai Kai – 1 March 1988 – Fourteen young Chinese marmots (Marmota bobak sibirica Radde) were randomly allocated to two groups of seven each. They were injected intrahepatically with a standard woodchuck hepatitis virus challenge pool or a negative pool, prepared from sera of woodchucks with and without woodchuck hepatitis virus infection, respectively. Marmot No.
Jose Chianale, Caroline Dvorak, Donna L. Farmer, Linda Michaels, Jorge J. Gumucio – 1 March 1988 – Hepatocytes of the right and left lobes of the fetal liver are surrounded by different microenvironments. The right and left lobes of the fetal liver are perfused by vascular systems carrying different concentrations of oxygen and constitute distinct functional units. The aim of this study was to assess the expression of the phenobarbital‐inducible cytochrome P‐450 b,e genes in hepatocytes of the right and left fetal liver lobes in mice.