1 July 1986

Jurgen Ludwig, Robert L. Maccarty, Nicholas F. Larusso, Ruud A. F. Krom, Russell H. Wiesner – 1 July 1986 – We studied intrahepatic bile ducts of five patients with chronic ulcerative colitis and primary sclerosing cholangitis. The livers had been obtained at the time of orthotopic liver transplantation. After specimen cholangiography and perfusion fixation, sequential blocks and sections from portal tracts were studied, combining light microscopy with scanning electron microscopy. In vivo cholangiograms were studied also.

David Westaby, Walter Melia, John Hegarty, Alexander E. S. Gimson, Anthony J. Stellon, Roger Williams – 1 July 1986 – In a prospective, randomized controlled trial, 53 patients with variceal hemorrhage from portal hypertension, including 44 with cirrhosis, were allocated, after initial control of the bleeding, to treatment by sclerotherapy alone, or by this together with oral propranolol in a dose sufficient to reduce resting pulse rate by 25% during the period up to the time when varices were obliterated.

José A. Solis‐Herruzo, José V. Vidal, Francisco Colina, Fermin Santalla, Gregorio Castellano – 1 July 1986 – Nodular regenerative hyperplasia of the liver developed in five patients who had the toxic oil syndrome caused by ingestion of adulterated cooking oil. This hepatic complication was detected from 19 to 37 months (mean‐2.5 years) after the onset of the toxic oil syndrome. Nodular regenerative hyperplasia was asymptomatic, although all patients had persistently abnormal liver function.

Peter van der Sluijs, Hans P. Bootsma, Bart Postema, Frits Moolenaar, Dirk K. F. Meijer – 1 July 1986 – The isolated perfused rat liver preparation was employed to study hepatic disposition of the model drugcarrier conjugate fluorescein‐lactosylated albumin (F‐LnHSA) with special reference to the influence of the organic anion fluorescein on liver cell specificity of the endocytosed neoglycoprotein. Hepatic clearance of fluoresceinated neoglycoproteins was significantly faster than clearance of radioiodinated neoglycoproteins.

H. Terry Wepsic – 1 July 1986

Sugantha Govindarajan, Kevin M. de Cock, Allan G. Redeker – 1 July 1986 – We evaluated the natural course of delta superinfection in patients with chronic B viral hepatitis by examining serial liver biopsy specimens from 23 patients. The mean follow‐up period was 2.5 years, and the average number of liver biopsies per patient was 2.8.

Tadashi Nishimura, Yukuo Yoshida, Fusao Watanabe, Masato Koseki, Toshiro Nishida, Kunio Tagawa, Yasunaru Kawashima – 1 July 1986 – To assess the severity of ischemic liver injury, we examined release of mitochondrial aspartate aminotransferase (EC 2.6.1.1) and its cytoplasmic isozyme from the ischemic rat liver into the circulation.

Peter F. Malet, Catherine L. Locke, Bruce W. Trotman, Roger D. Soloway – 1 July 1986 – The purpose of this study was to examine the role of calcium ions in gallbladder glycoprotein secretion in cultured guinea pig gallbladder explants. The calcium ionophore A23187 showed a threshold of 2 μg per ml medium for stimulation of secretion of [3H]glucosamine‐labeled glycoproteins over a 30 min incubation period. The ionophore at 3 and 5 μg per ml medium resulted in a 3‐ to 4‐fold increase in secretion of [3H]glucosamine‐labeled glycoproteins.

Bertrand Nalpas, Anne Vassault, Serge Charpin, Bernard Lacour, Pierre Berthelot – 1 July 1986 – Serum mitochondrial aspartate aminotransferase activity was measured using an immunochemical method in 251 subjects, of whom 140 were chronic alcoholics. The alcoholic patients included 37 with normal liver routine tests (Group I), 61 with noncirrhotic alcoholic liver disease (Group II) and 42 with cirrhosis (Group III), of whom 21 had been abstainers for at least 2 months.