Asghar Rastegar – 1 July 1986 – The assumption of upright posture by patients with liver cirrhosis leads to striking activation of adrenergic and renin‐angiotensin systems. The tilting‐induced modifications in renal function of eight healthy controls and 14 untreated patients with liver cirrhosis and ascites were related to plasma concentrations of noradrenaline, renin activity and aldosterone. All patients had preserved renal blood perfusion. All parameters were evaluated during bed rest for two hours and in the sitting posture for one hour.

Kunio Okuda – 1 July 1986

Yutaka Sasaki, Norio Hayashi, Akinori Kasahara, Hiroyuki Matsuda, Hideyuki Fusamoto, Nobuhiro Sato, Carmel J. Hillyard, Samia Girgis, Iain Macintyre, Piers C. Emson, Sadao Shiosaka, Masaya Tohyama, Yahe Shiotani, Takenobu Kamada – 1 July 1986 – The distribution and origin of calcitonin gene‐related peptide immunoreactive structures in hepatic and splanchnic vasculature of the rat were investigated by the immunofluorescent technique.

Arieh Bomzon, Moshe Rosenberg, Devorah Gali, Ofer Binah, Dani Mordechovitz, Ori S. Better, Paul D. Greig, Laurence M. Blendis – 1 July 1986 – Vascular instability as defined by systemic hypotension and unresponsiveness to endogenous or exogenous vasoactive substances is a feature of both patients and experimental animals with obstructive jaundice. In this study, we have attempted to dissect the possible mechanisms for these abnormalities using both in vivo and in vitro methods.

Robert H. Collins, Leon Lack, Kenneth M. Harman, Paul G. Killenberg – 1 July 1986 – A monoclonal antibody, PK1B, directed against rat liver bile acid sulfotransferase was used for the purification and characterization of the enzyme. Incubation of rat liver supernatant with the antibody followed by immunoprecipitation with Staphylococcus aureus cells demonstrated that PK1B reacted with 90% of the enzymatic activity present in the liver supernatant from female rats and 40 to 50% of the activity in male liver preparations.

1 May 1986

John Polio – 1 May 1986

Adrian M. Di Bisceglie, Jay H. Hoofnagle – 1 May 1986 – In an attempt to establish a model of the healthy carrier state in hepatitis B virus (HBV) infections, transgenic mice expressing HBV genes were produced. Fertilized one‐cell eggs were microinjected with subgenomic fragments of HBV DNA containing the coding regions for the HBV surface antigen (HBsAg) and pre‐S and×antigens. Either the normal (HBV) or metallothionein promoters were used to obtain expression of the HBV genes. There was no evidence of viral replication or tissue pathology.

Marshall M. Kaplan – 1 May 1986

Peter F. Malet, Clarke E. Williamson, Bruce W. Trotman, Roger D. Soloway – 1 May 1986 – Most cholesterol gallstones have visually pigmented centers, but it is unclear whether this represents simple co‐precipitation of pigment with cholesterol during stone nidation or nidation on a true pigment stone center. To clarify this issue, we selected from among 67 sets of cholesterol gallstones, 12 sets with the most conspicuously pigmented centers.