Surjit K. S. Srai, Andrew K. Burroughs, Bernard Wood, Owen Epstein – 1 May 1986 – The normal human neonate has a copper profile indistinguishable from Wilson's disease, and we have previously postulated that this disease is caused by genetic failure to switch from the fetal to adult mode of copper metabolism. This study validates the developing guinea pig as a suitable animal in which to study copper ontogeny. At birth, liver copper concentrations are 7 times higher than in adults and serum copper and ceruloplasmin are 27 and 21% of adult values, respectively.

E. L. Forker, B. A. Luxon, Carl A. Goresky, Glen G. Bach, Colin P. Rose, Allan W. Wolkoff – 1 May 1986

Arnold N. Cohen, Jaime Kapitulnik, J. Donald Ostrow, Cecile C. Webster – 1 May 1986 – 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin, a potent inducer of microsomal cytochrome P448‐dependent monoxygenases, and phototherapy both accelerate bilirubin metabolism and decrease jaundice in Gunn rats. The effects of combined treatment with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and light were studied in these rats by applying phototherapy for 65 hr, beginning 5 days after induction with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin.

Mohamed El Mouelhi, Frederick C. Kauffman – 1 May 1986 – Activities of glucuronosyltransferase, sulfotransferase, glutathione S‐transferase, β‐glucuronidase and sulfatase were determined in microdissected samples of periportal and pericentral sublobular regions from four human livers obtained at immediate autopsy. New methods are presented for the microdetermination of sulfotransferase and sulfatase activities in microdissected samples weighing 0.1 to 4 μg dry weight using umbelliferone and 4‐methylumbelliferone sulfate as substrates.

Hiroaki Okamoto, Sadakazu Usuda, Mitsunobu Imai, Katsumi Tachibana, Eiji Tanaka, Tomoko Kumakura, Masako Itabashi, Emiko Takai, Fumio Tsuda, Tetsuo Nakamura, Yuzo Miyakawa, Makoto Mayumi – 1 May 1986 – The antibody against the receptor for polymerized human serum albumin was determined by radioimmunoassay. The method involved the inhibition by the test serum, absorbed with HBsAg particles without the receptor, on the binding of polymerized human serum albumin to HBsAg particles with the receptor fixed on a solid support.

H. Reider, G. Ramadori, K.‐H. Meyer zum Büschenfelde, Bruce A. Runyon – 1 May 1986

Kunio Okuda – 1 May 1986

Richard J. Stenger – 1 May 1986 – During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients was found to have hepatic granulomas. Appropriate staining techniques showed acid‐fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms.

Bernard F. Smith, J. Thomas LaMont – 1 May 1986

Shin Ohnishi, Tohru Murakami, Takashi Moriyama, Keiji Mitamura, Michio Imawari – 1 May 1986 – Both androgen and estrogen receptors were studied in human hepatocellular carcinoma and noncancerous liver tissue surrounding it. Androgen receptor was detected in the cytosol and/or nucleosol of 4 of 8 cancerous tissues and 1 of 6 noncancerous tissues. The levels of androgen receptor in hepatocellular carcinomas ranged from 3.4 to 37.6 fmoles per mg protein with dissociation constants (Kd) of 0.226 − 51.3×10−9M.