Richard S. Aycock, Jerome M. Seyer – 1 March 1986

Tetsuo Yamamoto, Takeaki Suou, Chisato Hirayama – 1 March 1986 – Of 143 patients with pulmonary tuberculosis receiving isoniazid therapy, 52 (36%) had a transient elevation in serum aminotransferases. Among 74 patients taking isoniazid, rifampicin and streptomycin, 35 (47%) had such an increase, while of 69 patients taking isoniazid, amino‐salicylic acid and streptomycin, 17 (24%) did; this difference was significant. Isoniazid therapy could be continued in all patients with the abnormal test results.

Bruno Clement, Jean‐Alexis Grimaud, Jean‐Pierre Campion, Yves Deugnier, Andre Guillouzo – 1 March 1986 – Three collagen types (I, III and IV) and fibronectin were localized in normal and alcoholic human liver by light and electron microscopy using the indirect immunoperoxidase technique. In normal liver, most of the bundles of collagen fibers stained for type pro‐III collagen while only a few reacted for type I. Basement membranes stainedfor type IV collagen which formed discontinuous discrete deposits in sinusoids.

Tomohiko Nishihira, Junji Tanaka, Kastuhide Nishikawa, Akira Jikko, Yoshiro Taki, Taisuke Morimoto, Kenji Koizumi, Yasuo Kamiyama, Kazue Ozawa, Takayoshi Tobe – 1 March 1986 – Liver mitochondrial membrane potential was assessed during regeneration following partial hepatectomy in rabbits. Absorbance change of safranine O per milligram of mitochondrial protein was used to evaluate mitochondrial membrane potential. Absorbance change was calibrated to the membrane potential in millivolts produced by valinomycin‐induced potassium diffusion potential.

John T. Galambos – 1 March 1986

Kenichi Kitani – 1 March 1986

Michael M. Thaler – 1 March 1986 – A general impairment of liver mitochondrial enzymes is central to Reye's syndrome (RS). The respiration of isolated liver mitochondria was measured after the addition of concentrated normal serum or RS serum derived from 12 patients. RS serum stimulates oxygen consumption in isolated rat liver mitochondria. This effect is due to (a) the oxidation of uric acid by peroxisomes contaminating the preparation and (b) a stimulation of mitochondrial respiration (1.05 ± 0.14 nmole of O2/ min · mg of protein; control 0.30 ± 0.08 nmole O2/min · mg).

Alan G. Maloney, Douglas L. Schmucker, Donald S. Vessey, Rose K. Wang – 1 March 1986 – Studies were conducted to determine the effects of aging on certain biochemical andbiophysical properties of the hepatic microsomes and on the kinetic properties of a constituent drug‐metabolizing enzyme and a heme protein in a nonhuman primate. Outbred male and female rhesus monkeys (Macaque mulatta) ranging in age from 1 to 25 years were employed as animal models.

I. A. Rajkovic, Roger Williams – 1 March 1986 – Neutrophil functions of phagocytosis and intracellular killing of bacteria were examined in 40 patients with alcoholic cirrhosis of whom 18 had a superimposed acute alcoholic hepatitis. In 65% of these, defective neutrophil phagocytosis was demonstrable, and in 62.5% there was a defect of intracellular killing of either Staphylococcus aureus or Escherichia coli. Studies of the patients' serum failed to reveal inhibitors of neutrophil function.

Francis J. Dudley, Gary C. Kanel, Laurence J. Wood, Telfer B. Reynolds – 1 March 1986 – A urinary sodium concentration [U(Na)] of <10 mmoles per liter is considered important in differentiating hepatorenal syndrome from other causes of progressive renal impairment in patients with liver disease. However, occasionally, patients with hepatorenal syndrome have been recognized in whom the U(Na) is consistently >10 mmoles per liter. Eight such patients, in all of whom there was no clinical or laboratory evidence to implicate other causes of progressive renal impairment, were identified.