The relationship between glucagon and prostaglandin f in stimulating canine hepatic bile flow

D. L. Kaminski, Y. G. Deshpande – 1 March 1986 – Both glucagon and prostaglandin F2α have been shown to stimulate a chloride‐rich choleresis in dogs. This study was performed to ascertain the interrelationship between glucagon and prostaglandin F2α in stimulating bile flow. The experiments were performed using dogs with chronic biliary and gastric fistulas. Initially, the effects of prostaglandin F2α on serum glucagon levels were evaluated. Glucagon administration increased bile volume andchloride secretion as did prostaglandin F2α.

Assessment of short‐term prognosis after variceal bleeding in patients with alcoholic cirrhosis by early measurement of portohepatic gradient

J. P. Vinel, J. Cassigneul, M. Levade, J. J. Voigt, J. P. Pascal – 1 January 1986 – Seventy‐two consecutively admitted patients with biopsy‐proven alcoholic cirrhosis and a bleeding episode endoscopically proven to originate from ruptured esophageal varices were studied. Hemodynamic assessment was performedwithin 48 hr of admission using the transjugular approach.

Periductal fibrosis and lipocytes (fat‐storing cells or ito cells) during biliary atresia in the lamprey

Kazuhide Yamamoto, Patricia A. Sargent, Murray M. Fisher, John H. Youson – 1 January 1986 – Transmission and scanning electron microscopy were utilized to follow the degeneration of bile ducts of lampreys (Petromyzon marinus L.) during metamorphosis. The convoluted bile ducts of larval lampreys are surrounded by rich sinusoids, but this intimate biliovascular relationship is lost during metamorphosis because the bile duct degeneration is accompanied by the development of thick periductal fibrosis.

Terlipressin in bleeding esophageal varices: A placebo‐controlled, double‐blind study

Siegfried Walker M.D., Adolf Stiehl, Richard Raedsch, Burkhard Kommerell – 1 January 1986 – The effect of terlipressin (N‐α‐triglycyl‐8‐lysinevasopressin) in bleeding esophageal varices was evaluated in a prospective placebo‐controlled study. Fifty bleeding episodes from esophagealvarices in 34 patients were randomized. Standard therapy with transfusions, fluid and electrolyte correction, and lactulose was performed in both groups. Balloon tamponade was used in 20 bleeding episodes in the terlipressin group and in 19 bleeding episodes in the control group.

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