Akira Takada, Jinichi Nei, Shujiro Takase, Yoshiro Matsuda – 1 January 1986 – Although primary hepatoma is not very frequent in alcoholics, the incidence of hepatoma in cases of hepatitis B infection combined with heavy alcohol drinking is high. In the present study, the effects of chronic alcohol administration onthe development of chemicalinduced hepatic cancer in rats were analyzed. In 70% hepatectomized Wistar strain male rats, asingle dose (1 mg per 100 gm body weight) of diethylnitrosamine was injected intraperitoneally.

Ignacio Mora, Juan Carlos Porres, Carlos Hernández Guio, Julia Gutiez, Vicente Carreño – 1 January 1986 – The binding activity of polymerized human serum albumin was determined in 202 HBsAg carriers. The presence of polymerized human serum albumin receptor sites was tested by hemagglutination and differentiated from antihuman albumin antibodies by immunofluorescence, isolation of IgG and IgM fractions and testing of HBsAg anti‐HBs immune complexes. A granular pattern with anti‐HBs was specific for polymerized human serum albumin receptor sites as demonstrated with purified HBsAg.

John R. Lake, Bruce F. Scharschmidt, Peter Thomas, Norman Zamcheck – 1 January 1986

Carlos Caramelo, Dolores Fernandez‐Muñoz, Juan C. Santos, Alicia Blanchart, Diego Rodriguez‐Puyol, José M. López‐Novoa, Luis Hernando – 1 January 1986 – General and splanchnic hemodynamics (radioactive microspheres), renal function, spontaneous and histamine‐mediated vasopermeability and albumin distribution space were studied in conscious control and nonascitic cirrhotic rats, before and after a moderate and sustained saline infusion (3% of body weight per 30 min + repletion of urinary losses).

Bernard Willems, Jean‐Pierre Villeneuve, P.‐Michel Huet – 1 January 1986 – Propranolol has been reported to reduce portal and wedged hepatic vein pressures in man and may be useful for the prevention of variceal bleeding. However, its mechanism of action remains unclear. We have examined the effect of propranolol on the systemic and hepatic circulations in dogs with chronic bile duct ligation and secondary biliary cirrhosis. Underanesthesia, eight dogs received four increasing doses of propranolol as an i.v. bolus followed by continuous infusion.

Yukihisa Nagafuchi, Professor Peter J. Scheuer – 1 January 1986 – β2−Microglobulin display was examined in 131 liver biopsies from patients with acute and chronic type B hepatitis, using an indirect immunoperoxidase method. Enhanced expression of β2−microglobulin on hepatocyte membranes was observed in patients with acute hepatitis, chronic active hepatitis with moderate to severe activity and cirrhosis, when compared with normal liver. In acute hepatitis, β2−microglobulin‐positive hepatocytes were mainly observed in perivenular areas in association with bridging necrosis.

1 January 1986

Andres T. Blei – 1 January 1986

Anton L. Boks, Emile J. P. Brommer, Solko W. Schalm, Huub H. D. M. Van Vliet – 1 January 1986 – In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters ofhemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly from each other in coagulation or in fibrinolytic parameters, although liver function was more impaired in nonalcoholic cirrhosis.

Linus Chang, Peter Clifton, Philip Barter, Malcolm Mackinnon, M.D. – 1 January 1986 – Severe liver disease may be associated with a reduction in plasma concentration of high density lipoprotein and an impairment of plasma cholesterol esterification. These changes were confirmed in two patients with severe acute on chronic alcoholic liver disease.