Hemostasis and fibrinolysis in severe liver failure and their relation to hemorrhage

Anton L. Boks, Emile J. P. Brommer, Solko W. Schalm, Huub H. D. M. Van Vliet – 1 January 1986 – In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters ofhemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly from each other in coagulation or in fibrinolytic parameters, although liver function was more impaired in nonalcoholic cirrhosis.

CCl4−induced toxicity in isolated hepatocytes: The importance of direct solvent injury

Marc L. Berger, Harshika Bhatt, Burton Combes, Ronald W. Estabrook – 1 January 1986 – CCl4 is proposed to induce cellular injury through its metabolites that are generated by a cytochrome P‐450 dependent step. These free radical products can interact with membrane structures, thereby generating lipid peroxides. The latter process has been implicated as a major mechanism of CCl4 hepatoxicity, although this relationship has been difficult to demonstrate when using isolated hepatocyte preparations.

Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload

Maud I. Cleton, Jan W. Sindram, Louk H. P. M. Rademakers, Floris M. J. Zuyderhoudt, Willem C. De Bruijn, Joannes J. M. Marx – 1 January 1986 – Ferritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.

The usefulness of microscopic bile examination in patients with suspected microlithiasis: A prospective evaluation

Jean‐Charles Delchier, Paul Benfredj, Anne‐Marie Preaux, Jean‐Michel Metreau, Daniel Dhumeaux – 1 January 1986 – Gallbladder bile collected by duodenal intubation or during surgery was examined microscopically in patients who werefree of stones and in patients with proven stones. None of the 16 patients free of stones had cholesterol monohydrate crystals or calcium bilirubinate granules in bile.

Short‐term effects of propranolol on portal venous pressure

Guadalupe Garcia‐Tsao, Norman D. Grace, Roberto J. Groszmann, Harold O. Conn, Max M. Bermann, Michael J. C. Patrick, Steven S. Morse, Jeanne L. Alberts – 1 January 1986 – The present study was designed to investigate the effect of propranolol on portal pressure of patients with alcoholic cirrhosis and portal hypertension and to correlate these effects with clinical and laboratory parameters. The mean baseline hepatic venous pressure gradient in the 50 patients studied was of 18.2 ± 4.1 mm Hg.

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