Alberto Galvaõ‐Teles, Estela Monteiro, Judith S. Gavaler, David H. Van Thiel – 1 January 1986

Francesco Cetta, Angelo Denisi, Peter F. Malet, Roger D. Soloway – 1 January 1986

Andres T. Blei, Jeanne Gottstein – 1 January 1986 – Isosorbide dinitrate, a long‐acting vasodilator, has been tested in human portal hypertension with conflictingresults. In order to determine some of the factors that could affect the individual response to this drug, we infused isosorbide dinitrate at a low dose (10 to 25 μg per kg per min) and a high dose (100 μg per kg per min) to rats with portal vein stenosis.

Richard J. Stockert, Phyllis S. Grushoff, Anatol G. Morell, Glenn E. Bentley, Harold A. O'Brien, I. Herbert Scheinberg, Irmin Sternlieb – 1 January 1986 – The uptake of radiocopper by HepG2 cells is a saturable, temperature‐dependent and cellular energy‐independent process with a Vmax of 7.1 ± 0.2 pmoles min−1 mg protein−1 andan estimated Km of 3.3 ± 0.5 μM. The rate of copper uptake is reduced at an equimolar concentrationof albumin and is unaffected by zinc at a 10‐fold molar excess.

Mark L. Bassett, June W. Halliday, Lawrie W. Powell – 1 January 1986 – The role of the measurement of hepatic iron in the diagnosis of genetic hemochromatosis was studied, with particular reference to the differentiation of early hemochromatosis from alcoholic siderosis and the critical hepatic iron concentration associated with fibrosis in hemochromatosis. Hepatic iron was measured in 30 homozygous relatives of 17 hemochromatosis probands, 8 heterozygous relatives, 51 patients with alcoholic liver disease and 40 control subjects.

Byers W. Shaw – 1 November 1985

Albert L. Jones, Gary T. Hradek, Douglas L. Schmucker – 1 November 1985 – It is well established that in the rat, rat dimeric IgA is transported from blood to bile across rat liver parenchymal cells via a series of minute smooth membrane‐limited vesicles. This pathway is unique from that taken by a number of other ligands, which are internalized for degradation, in that there appears to be little involvement of coated vesicles, multivesicular bodies and lysosomes.

Henry C. Bodenheimer, Fenton Schaffner, Irmin Sternlieb, Franklin M. Klion, Salvatore Vernace, John Pezzullo – 1 November 1985 – We conducted a prospective clinical trial to assess the relative efficacy and safety of high‐ vs. low‐dose D‐penicillamine in patients with primary biliary cirrhosis. Following clinical tests and liver biopsy diagnostic of primary biliary cirrhosis, 56 patients were randomized to receive either 250 or 750 mg D‐penicillamine daily. Patients were monitored with clinical tests and annual liver biopsy.

Ashok K. Batta, Gerald Salen, Sarah Shefer – 1 November 1985 – We have examined the mechanism for the bacterial transformation of chenodeoxycholic acid and lithocholic acid into the corresponding 3β‐hydroxy epimers with the use of 3α‐ and 3β‐tritiated bile acids. The 3‐oxo bile acids were transformed into the 3α‐ (85%) and 3β‐ (15%) hydroxy bile acids after 20‐hr incubation with Clostridium perfringens.

Eduardo A. Porta, Nalani Markell, Russell D. Dorado – 1 November 1985 – To determine whether the chronic consumption of ethanol was capable of enhancing the hepatocarcinogenic activity of diethylnitrosamine per se, or through the accentuation of a methyl deficiency, two groups (A and B) of Sprague‐Dawley female rats were fed for 10 months either a 20% casein basal diet marginally deficient in methyl, or the same diet supplemented with choline (1 gm per 100 gm) and folic acid (0.54 mg per 100 gm).