Fumio Nomura, Kunihiko Ohnishi, Hirofumi Koen, Shinji Iida, Yuichi Tanabe, Hitoshi Hatano, Kunio Okuda – 1 November 1985 – To evaluate the effects of anaerobic conditions and inducers for the mixed‐function oxidase system on the metabolism of mitomycin C, a bioreductive alkylating agent widely used for the treatment of hepatocellular carcinoma, experiments so designed were performed in rats and mice.

Olivier Amédée‐Manesme, Harold C. Furr, Fernando Alvarez, Michelle Hadchouel, Daniel Alagille, James Allen Olson – 1 November 1985 – Biochemical indicators of vitamin A status were measured in 24 children (1 month to 6 years old) with severe cholestasis starting early in life and in 21 children (3 months to 13 years old) with liver disease but without cholestasis. Liver vitamin A concentrations, expressed as micrograms of retinol per gram of liver (mean ± S.D.), were 6.3 ± 7.1 (range: 0.14 to 28) and 143 ± 108 (range: 18 to 424), respectively, in cholestatic and noncholestatic children.

Masashi Unoura, Kenichi Kobayashi, Kenichi Fukuoka, Fumiaki Matsushita, Hideo Morimoto, Tohru Oshima, Shuichi Kaneko, Nobu Hattori, Seishi Murakami, Hiroshi Yoshikawa – 1 November 1985 – A new cell line derived from a woodchuck hepatocellular carcinoma serially transplanted in athymic nude mice has been established and named WH257GE10. The original tumor in the nude mouse system produces woodchuck hepatitis surface antigen and albumin. In addition, woodchuck hepatitis virus DNA is integrated into cellular DNA.

Karen L. Lindsay, David A. Herbert, Gary L. Gitnick – 1 November 1985 – Although other investigators have found excellent response rates to the hepatitis B vaccine, we report here an unusually low rate of seroconversion following hepatitis B vaccination in a group of apparently healthy medical center personnel. Only 67% of these individuals developed adequate postvaccination antibodies to HBsAg, in contrast to 85 to 96% in other studies.

Michael J. O'Brien, Leonard S. Gottlieb – 1 November 1985

Charles E. Cornelius – 1 November 1985

Anna S. F. Lok, David M. Novick, Peter Karayiannis, Arthur A. Dunk, Sheila Sherlock, Howard C. Thomas – 1 November 1985 – A previous randomized controlled study has shown a 30% rate of HBe antigen/antibody serocon‐version within 1 year of a month course of adenine arabinoside‐5′‐monophosphate; no seroconversion occurred in the control group.

Arie J. Zuckerman – 1 November 1985

1 November 1985

Ian R. Wanless, Carolyn Mawdsley, Ronald Adams – 1 November 1985 – Fifty‐one focal nodular hyperplasia lesions from 36 patients were examined histologically. Serial sections and three‐dimensional models were studied in selected cases. Lesions were multiple in 19% of patients. Thirty‐four patients were female. One case had 11 focal nodular hyperplasia lesions and 7 hemangiomata in the liver. Three had astrocytoma and one had anomalous pulmonary venous drainage.