Henry C. Bodenheimer, Fenton Schaffner, Irmin Sternlieb, Franklin M. Klion, Salvatore Vernace, John Pezzullo – 1 November 1985 – We conducted a prospective clinical trial to assess the relative efficacy and safety of high‐ vs. low‐dose D‐penicillamine in patients with primary biliary cirrhosis. Following clinical tests and liver biopsy diagnostic of primary biliary cirrhosis, 56 patients were randomized to receive either 250 or 750 mg D‐penicillamine daily. Patients were monitored with clinical tests and annual liver biopsy.

Albert L. Jones, Gary T. Hradek, Douglas L. Schmucker – 1 November 1985 – It is well established that in the rat, rat dimeric IgA is transported from blood to bile across rat liver parenchymal cells via a series of minute smooth membrane‐limited vesicles. This pathway is unique from that taken by a number of other ligands, which are internalized for degradation, in that there appears to be little involvement of coated vesicles, multivesicular bodies and lysosomes.

Byers W. Shaw – 1 November 1985

Catherine L. Troisi, F. Blaine Hollinger – 1 September 1985 – An IgM‐specific anti‐[anti‐HBs] antibody was detected by radioimmunoassay using anti‐IgM‐coated beads and 125I‐labeled anti‐HBs. This antiidiotype was found only in the sera of hepatitis B virus‐infected patients, both acute and chronic. However, not all HBsAg‐positive patients exhibited this reaction, and activity was correlated with the presence of HBeAg. Approximately 93% of sera that contained antiidiotype activity also contained HBeAg. Conversely, 70% of the sera positive for HBeAg reacted in the IgM assay.

Mack C. Mitchell, James J. Potter, Esteban Mezey, Helmut K. Seitz, Siegrid Veith, Peter Czygan, Johann Bösche, Bernd Simon, Burkhard Simon, Roland Gugler – 1 September 1985

1 September 1985

1 September 1985

Masayasu Inoue – 1 September 1985

Robert J. Fallon, Alan L. Schwartz – 1 September 1985

Jean‐Claude Homberg, Nielsen Abuaf, Samir Helmy‐Khalil, Michel Biour, Raoul Poupon, Shamsul Islam, François Darnis, Victor Georges Levy, Pierre Opolon, Michel Beaugrand, Jacques Toulet, Gaby Danan, Jean‐Pierre Benhamou – 1 September 1985 – A study from five hepatology units documenting 157 cases of drug‐induced hepatitis and a second study from a laboratory of immunology which tested more than 100,000 sera permitted us to establish the frequency of antiorganelle antibodies and their diagnostic value in drug‐induced hepatitis.