Robert J. Fallon, Alan L. Schwartz – 1 September 1985

Jean‐Claude Homberg, Nielsen Abuaf, Samir Helmy‐Khalil, Michel Biour, Raoul Poupon, Shamsul Islam, François Darnis, Victor Georges Levy, Pierre Opolon, Michel Beaugrand, Jacques Toulet, Gaby Danan, Jean‐Pierre Benhamou – 1 September 1985 – A study from five hepatology units documenting 157 cases of drug‐induced hepatitis and a second study from a laboratory of immunology which tested more than 100,000 sera permitted us to establish the frequency of antiorganelle antibodies and their diagnostic value in drug‐induced hepatitis.

Esteban Celis, Ikunoshin Kato, Richard W. Miller, Tse Wen Chang – 1 September 1985 – The role of accessory cells (antigen‐presenting cells) in binding HBsAg in the response of human T cells to this antigen was studied. Antibodies to HBsAg of IgG class increased significantly the amount of HBsAg that was captured and internalized by accessory cells in vitro. On the other hand, antibodies to HBsAg of IgM class or the F(ab‐)2 and Fab fragments of antibodies to HBsAg of IgG class did not modify the amount of HBsAg associated to these cells.

Jutta Lindenborn‐Fotinos, Harold Baum, Peter A. Berg – 1 September 1985 – Sera from patients with primary biliary cirrhosis reacted with four major bands in beef heart mitochondria and ATPase extract when analyzed by immunoblot after sodium dodecyl sulfate‐polyacrylamide gel electrophoresis. These four immunologically reactive bands corresponded to protein bands with molecular weights of about (a) 80,000; (b) 63,000; (c) 56,000; and (d) 43,000 to 46,000. An additional immunoreactive band was found with some high‐titered primary biliary cirrhosis sera at 36,000.

Kurt Lenz, Heide Hörtnagl, Dieter Magometschnigg, Gunter Kleinberger, Wilfred Druml, Anton Laggner – 1 September 1985 – To obtain further pathophysiological details concerning the development of cardiovascular disturbances in severe liver disease, the state of the autonomic nervous system, the function of the baroreceptor reflex pathway and the responsiveness of the cardiovascular system to noradrenaline, angiotensin II and isoprenaline were investigated in 11 patients with hepatic encephalopathy and in 10 healthy control subjects.

1 September 1985

Bruce R. Bacon, Chanho H. Park, Gary M. Brittenham, Rosemary O‐Neill, Anthony S. Tavill – 1 September 1985 – We examined the effects of chronic dietary iron overload on hepatic mitochondrial oxidative metabolism. Experimental iron overload was produced by feeding rats a chow diet supplemented with carbonyl iron over a 7‐week period. Biochemical and histologic evaluations of liver tissue confirmed moderate degrees of hepatic parenchymal iron overload.

Agesilao D‐Arienzo, Gabriella Ambrogio, Pasqualina Di Siervi, Enzo Perna, Giovanni Squame, Gabriele Mazzacca – 1 September 1985 – The effect of metoclopramide and domperidone, two dopamine antagonists, administered to cirrhotic patients with ascites and secondary hyperaldosteronism, was examined to evaluate the changes in plasma aldosterone levels and in spironolactone‐induced diuresis.

Dietrich Keppler, Wolfgang Hagmann, Stephan Rapp, Claudio Denzlinger, Herbert K. Koch – 1 September 1985

Kim Krogsgaard, Jan Aldershvile, Peter Kryger, Poul Andersson, Jens Ole Nielsen, Bengt Göran Hansson, The Copenhagen Hepatitis Acuta Programme – 1 September 1985 – The presence of hepatitis B virus DNA in serum was determined in 57 unselected patients during the course from acute to chronic hepatitis B infection. Forty‐six (81%) patients were hepatitis B virus DNA‐positive in the first available serum sample. Generally, hepatitis B virus DNA was cleared before or at the same time as HBeAg, but in two patients (4%), hepatitis B virus DNA could be demonstrated after HBeAg clearance.