Harshika S. Bhatt, Burton Combes – 1 July 1985 – The effect of hepatic glutathione depletion on 14CO2 evolution from [14C]methyl‐labeled aminopyrine was assessed in fed male Sprague‐Dawley rats. Within 30 min of i.p. administration of either diethylmaleate or phorone, hepatic glutathione fell approximately 75 to 80% and remained depressed for the ensuing 120 min. [14C]Aminopyrine was i.p. administered 30 min after the glutathione‐lowering agents (zero time) and exhaled 14CO2 was collected at 15‐min intervals for the next 120 min.

Jacob Korula, Luis A. Balart, George Radvan, Bruce E. Zweiban, Alan W. Larson, Henry W. Kao, Suyenori Yamada – 1 July 1985 – The results of a prospective, randomized controlled trial of chronic esophageal variceal sclero‐therapy conducted over a 38‐month period are presented. One‐hundred twenty patients were randomized following variceal bleeding, 63 to esophageal variceal sclerotherapy and 57 to control. Mean follow‐up was similar in both groups (esophageal variceal sclerotherapy, 12.5 ± 8.8 months; control, 14.9 ± 6.6 months).

1 July 1985

Kwesi N. Tsiquaye, Thomas F. McCaul, Arie J. Zuckerman – 1 July 1985 – A 14‐month old female Pekin duck experimentally infected as an embryo with duck hepatitis B virus via the amniotic route has been a chronic carrier of duck hepatitis B virus with very high (P/N) values of DNA polymerase activity since hatching. All the progeny were, on evaluation for congenital infection, found to be duck hepatitis B virus positive by endogenous DNA polymerase reaction and electron microscopy. These offspring remained persistently viremic throughout the study.

Charles S. Lieber, Maria A. Leo, Ki M. Mak, Leonore M. Decarli, Shinkichi Sato – 1 July 1985 – To determine how choline supplementation affects the liver and whether it can protect against ethanol‐induced liver injury, baboons were fed either normal or choline‐supplemented diets, each with or without ethanol. Eighteen baboons were pair‐fed for 3 to 4 years liquid diets with 50% of total energy as ethanol or isocaloric carbohydrate; ten animals were given our regular diets, whereas in eight the choline content was increased 5‐fold.

Frank L. Iber – 1 July 1985

Leon Schiff – 1 July 1985

Kurt Einarsson, Jon Ahlberg, Bo Angelin, Ingemar Björkhem, Staffan Ewerth – 1 July 1985 – We determined the serum concentrations of cholic, chenodeoxycholic and deoxycholic acids in portal and peripheral venous blood in 9 gallstone‐free patients and 39 patients with cholesterol gallstones during standardized cholecystectomy. An accurate and specific gas chromatographic‐mass spectrometric technique was used.

Yuro Shibayama, Katsuji Nakata – 1 July 1985 – To determine the localization of increased vascular resistance in cirrhotic liver, blood pressures were measured by a direct cannulation method at several key points in the hepatic vascular pathway in normal and cirrhotic rats. Cirrhosis was produced by feeding a choline‐deficient diet. Blood pressures in normal rats were 110 mm H2O in the portal vein, 68 mm H2O in the terminal portal venule, 28 mm H2O in the terminal hepatic venule and 20 mm H2O in the inferior vena cava.

I. Sendama, B. de Hemptinne, L. Lambotte – 1 July 1985 – Aminopyrine demethylation was investigated in rats after a 70% hepatectomy to assess possible parallelism between the recovery of mass and function. Tests were performed by analyzing 14CO2 exhalation from 0.1 μCi per 100 gm of body weight of [dimethylamine‐14C]aminopyrine given intraperitoneally with incremental doses of unlabeled drug.