Effects of ioglycamide on the hepatic transport of bilirubin and its mono‐ and diconjugates in the rat

Vital A. Mesa, Johan Fevery, Karel P. M. Heirwegh, Jan De Groote – 1 July 1985 – Bilirubin seems to share the biliary excretion pathway with other organic anions, but not with bile acids. We studied the effects of the organic anion ioglycamide, an iodinated contrast agent, on bilirubin metabolism in Wistar rats. This compound does not undergo conjugation and is characterized by a maximal biliary secretory rate (Tm).

Acetaminophen‐induced fulminant hepatic failure in Dogs

L. Ortega, J. I. Landa Garcia, A. Torres Garcia, G. Silecchia, J. Arenas, A. Suarez, M. Moreno Azcoitia, J. Sanz Esponera, E. Moreno Gonzalez, J. L. Balibrea Cantero – 1 July 1985 – Results concerning morphological and biochemical changes following intravenous administration of different doses of acetaminophen in dogs are reported. Acetaminophen infusion, as a parenteral solution (500 mg per kg per 90 min), produced fulminant hepatitis characterized by a good correlation between Portmann's grade of lesion and percentage of necrosis. All animals died within 76 hr after intoxication.

Functional properties of isolated hepatocytes from ethanol‐treated rat liver

Amador Schüller, Jorge Moscat, Emilio Diez, Jose C. Fernandez‐Checa, Francisco G. Gavilanes, Angel M. Municio – 1 July 1985 – Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol‐treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol‐treated animals; palmitate incorporation into triacylglycerols increased.

The effect of glutathione depletion on 14CO2 evolution from [14C] methyl‐labeled aminopyrine in intact rats

Harshika S. Bhatt, Burton Combes – 1 July 1985 – The effect of hepatic glutathione depletion on 14CO2 evolution from [14C]methyl‐labeled aminopyrine was assessed in fed male Sprague‐Dawley rats. Within 30 min of i.p. administration of either diethylmaleate or phorone, hepatic glutathione fell approximately 75 to 80% and remained depressed for the ensuing 120 min. [14C]Aminopyrine was i.p. administered 30 min after the glutathione‐lowering agents (zero time) and exhaled 14CO2 was collected at 15‐min intervals for the next 120 min.

A prospective, randomized controlled trial of chronic esophageal variceal sclerotherapy

Jacob Korula, Luis A. Balart, George Radvan, Bruce E. Zweiban, Alan W. Larson, Henry W. Kao, Suyenori Yamada – 1 July 1985 – The results of a prospective, randomized controlled trial of chronic esophageal variceal sclero‐therapy conducted over a 38‐month period are presented. One‐hundred twenty patients were randomized following variceal bleeding, 63 to esophageal variceal sclerotherapy and 57 to control. Mean follow‐up was similar in both groups (esophageal variceal sclerotherapy, 12.5 ± 8.8 months; control, 14.9 ± 6.6 months).

Maternal transmission of duck hepatitis B virus in pedigree pekin ducks

Kwesi N. Tsiquaye, Thomas F. McCaul, Arie J. Zuckerman – 1 July 1985 – A 14‐month old female Pekin duck experimentally infected as an embryo with duck hepatitis B virus via the amniotic route has been a chronic carrier of duck hepatitis B virus with very high (P/N) values of DNA polymerase activity since hatching. All the progeny were, on evaluation for congenital infection, found to be duck hepatitis B virus positive by endogenous DNA polymerase reaction and electron microscopy. These offspring remained persistently viremic throughout the study.

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