Thomas B. Leonard, D. Gwyn Morgan, John G. Dent – 1 May 1985 – Cimetidine has been shown to protect against acetaminophen‐mediated hepatotoxicity in both rats and mice. In contrast to cimetidine, ranitidine recently has been determined to potentiate the hepatotoxic action of acetaminophen in Fischer 344 rats. The present studies were designed to characterize this ranitidine‐acetaminophen interaction. Acetaminophen administration (750 mg per kg, p.o.) to F344 rats produced maximal hepatic necrosis, 24 hr after treatment, as assessed by SGPT activity and histopathology.

Daniel Shouval, Dan Eilat, Rolf I. Carlson, Ruth Adler, Nelly Livni, Jack R. Wands – 1 May 1985 – A library of murine monoclonal antibodies reactive with human hepatoma cells was generated following immunization of Balb/c mice with an intact cloned human hepatoma cell line, designated PLC/PRF/5‐NR. We report the characterization of one such IgG2a antibody, designated anti‐PLC1.

Rafael Esteban, Maria Buti, Rosendo Jardi, Jamie Guardia, Ding‐Shinn Chen, Ming‐Yang Lai, Juei‐Low Sung, George Papevangelou, Nicolaos Tassopoulos, Anastasia Roumeliotou‐Karayannis, Clive Richardson – 1 May 1985

Marie‐Laurence Roquet, Elie‐Serge Zafrani, Jean‐Pierre Farcet, Félix Reyes, Yvon Pinaudeau – 1 May 1985 – Pathological lesions of the liver were studied in 14 cases of hairy cell leukemia, a rare hematologic neoplasm involving numerous organs. Tumor infiltration of hepatic parenchyma was observed in all cases. Tumor cells were easily recognized by their cytological features, namely their “halo” appearance consisting of a clear rim of abundant cytoplasm surrounding uniform round or slightly indented nuclei.

David E. Moody, Lorna A. Taylor, Edward A. Smuckler – 1 May 1985 – We have used an immunohistochemical approach to study the lobular distribution of constitutive liver microsomal cytochrome P‐450. Cytochrome P‐450 isolated (10.3 nmoles per mg protein) from hepatic microsomes from untreated, mature male Sprague‐Dawley rats was used to produce antisera in rabbits.

Lawrence E. Gurian, Thomas M. Rogoff, Athol J. Ware, Robert E. Jordan, Burton Combes, James N. Gilliam – 1 May 1985 – We have evaluated the immunologic characteristics often associated with systemic lupus erythematosus in a series of patients with a variety of different liver diseases. Antibody to doublestranded DNA as measured by the Farr assay was detected frequently in patients with various forms of liver disease. No patient with liver disease, including those with a presumed immunologic etiology, was found to have antibody to double‐stranded DNA using more specific assays.

Gaetano Cairo, Lidia Bardella, Luisa Schiaffonati, Aldo Bernelli‐Zazzera – 1 May 1985 – Ischemia of rat liver is followed by recovery or cell death. Since heat shock proteins may be essential to cell survival under stress, we determined levels of heat shock proteins in liver after different periods of blood deprivation and correlated the results with cellular recovery. Cell‐free synthesis by poly (A+)‐mRNA and polysomes revealed 70 and 89 kd proteins which appear similar to proteins produced by the liver of rats with amphetamine‐induced hyperthermia.

Adriaan Brouwer, Roel J. Barelds, Dick L. Knook – 1 May 1985 – There are many indications that the functional capacity of the reticuloendothelial system (RES) declines with age. The aim of this study was to investigate the cellular basis of age‐related changes in the clearance function of the RES. The experiments were focused mainly on Kupffer and endothelial cells of the liver which represent a major part of the RES and are primarily responsible for clearance of colloidal material from the circulation.

1 May 1985

James German – 1 May 1985