Acetaminophen‐Induced hepatotoxic congestion in mice

Robin M. Walker, William J. Racz, T. Francis McElligott – 1 March 1985 – Acetaminophen‐induced (750 mg per kg p.o.) hepatotoxicity in mice is characterized by hepatomegaly and massive centrilobular congestion which precede the appearance of necrosis. The vascular changes are correlated with the morphologic features using liver hemoglobin content to quantitate erythrocyte sequestration, and hematocrit measurements and 125I‐albumin injections to determine plasma and blood volume.

T lymphocyte sensitization to hbcag and T cell‐mediated unresponsiveness to HBsAg in hepatitis B virus‐related chronic liver disease

Sandro Vento, John E. Hegarty, Alfredo Alberti, Charles J. O'brien, Graeme J. M. Alexander, Adrian L. W. F. Eddleston, Roger Williams – 1 March 1985 – Using a newly developed indirect T lymphocyte migration inhibition test, cell‐mediated immunity to HBsAg and HBcAg was directly and simultaneously examined in a total of 21 patients with HBsAg‐positive chronic liver disease (CLD), and in seven subjects whose sera contained anti‐HBs (2 previous acute hepatitis B; 4 hepatitis B vaccine recipients and 1 chronic active hepatitis).

Epidemiology and clinical impact of hepatitis D virus (delta) infection

Ira M. Jacobson, Jules L. Dienstag, Barbara G. Werner, Doreen B. Brettler, Peter H. Levine, Isa K. Mushahwar – 1 March 1985 – We tested sera collected between 1976 and 1984 from 362 persons in a variety of epidemiologic categories with acute and chronic hepatitis B and from 76 hemophiliacs and drug addicts with hepatitis B antibodies for hepatitis D markers.

Rheumatoid factor‐like reactants in sera proven to transmit non‐A, non‐B hepatitis: A potential source of false‐positive reactions in non‐A, non‐B assays

Hiroyuki Shiraishi, Harvey J. Alter, Stephen M. Feinstone, Robert H. Purcell – 1 March 1985 – Convalescent phase non‐A, non‐B (NANB) human and chimpanzee sera were utilized in a solid‐phase radioimmunoassay (RIA) in an attempt to identify a specific NANB antigen in human plasma, plasma‐derived pellets and NP‐40 disrupted pellets proven to transmit NANB infection to chimpanzees. RIA reactivity was noted in 5 of 8 pedigreed NANB infectious plasmas, but did not appear to be virus‐specific.

Tubular dysfunction in the deeply jaundiced patient with hepatorenal syndrome

William G. Rector, Gary C. Kanel, Jorge Rakela, Telfer B. Reynolds – 1 March 1985 – We examined β2‐microglobulin (B2MG) excretion, an index of tubular function, in patients with hepatorenal syndrome, in whom tubular function is generally regarded as normal. Urine B2MG was significantly higher in these patients than in control patients with normal serum creatinine concentration. Patients with high urine B2MG concentration had markedly higher serum bilirubin than did patients with normal values (31 ± 3 vs.

Viral hepatitis in Colombia: A study of the “hepatitis of the Sierra Nevada de Santa Marta”

Karin E. Ljunggren, Manuel E. Patarroyo, Ronald Engle, Robert H. Purcell, John L. Gerin – 1 March 1985 – The prevalences of hepatitis B virus (HBV), hepatitis delta virus and hepatitis A virus infections were studied in two regions of Colombia. In Bogota, 10 of 53 patients with acute hepatitis were HBsAg positive and three of these were hepatitis D antigen positive. Hepatitis A virus was the major cause of acute hepatitis in this group. In 366 healthy controls from Bogota, 1.6% were HBsAg positive and 7.1% had at least one marker of HBV infection.

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