Edward Lebovics, Swan N. Thung, Fenton Schaffner, Paul W. Radensky – 1 March 1985 – We reviewed the clinical data and hepatic histologic findings of 25 patients with the acquired immunodeficiency syndrome who underwent 29 liver biopsies. Our experience indicates that the only hepatic feature characteristic of acquired immunodeficiency syndrome is serologic evidence of exposure to the hepatitis B virus. The most common histologic finding was macrovesicular steatosis.

Bruce A. Runyon, John C. Hoefs – 1 March 1985 – A retrospective analysis of 22 patients whose ascitic fluid had been analyzed prior to the onset of spontaneous bacterial peritonitis, during infection and/or after treatment of peritonitis revealed that neither the ascitic fluid total protein nor the absolute ascitic fluid glucose changed during the infection or after treatment of the infection although the ascitic fluid/serum glucose ratio did decrease (p < 0.001) with infection.

Mario Baraldi, Gary W. Goldstein – 1 March 1985

Arnold N. Cohen, Jaime Kapitulnik, J. Donald Ostrow, Eugene A. Zenone, Cecile Cochrane, Lillian Celic, Heidemarie Cheney – 1 March 1985 – Jaundiced Gunn rats, treated with phenobarbital (60 mg per kg i.p. for 7 to 10 days) showed 25 and 36% decreases in mean plasma bilirubin levels in two experiments (p < 0.01). Kinetic studies with tracer 14C‐bilirubin revealed that there was no change in bilirubin turnover or total pool size due to phenobarbital, but a 49% increase in the hepatic pool and a 27% decrease in the cutaneous pool of bilirubin.

Shunichi Koga, Yasuji Miyata, Hiroshi Ibayashi – 1 March 1985 – To elucidate abnormalities in lipid metabolism in patients with primary biliary cirrhosis (PBC), plasma lipoproteins and apoproteins were analyzed in 10 such patients. Lipoprotein X was present in sera from five of the patients. Another abnormal lipoprotein of slow α‐mobility on agarose gel electrophoresis was observed in sera of eight of the patients. The slow α‐lipoprotein was distributed in the range of densities between low density and high density lipoproteins and was rich in apoprotein E.

Anders Nyberg, Lars Lööf, Roger Hällgren – 1 March 1985 – Serum β2‐microglobulin (β2μ) was determined in 44 patients with primary biliary cirrhosis (PBC) and in 63 patients with other liver disorders. β2μ levels were elevated in PBC when compared with chronic persistent hepatitis, primary sclerosing cholangitis and noncirrhotic alcohol liver disease, but not in comparison with chronic active hepatitis and alcoholic liver cirrhosis. With the exception of chronic persistent hepatitis, all liver disorders had significantly increased serum concentrations of β2μ when compared with controls.

Armelle Foliot, Denise Glaise, Serge Erlinger, Christiane Guguen‐Guillouzo – 1 March 1985 – Taurocholate (TC) uptake by adult rat hepatocytes co‐cultured with other rat liver epithelial cells (RLEC) was studied comparatively to hepatocytes in primary culture. Cells were cultured on Petri dishes for desired times prior to measuring their ability to transport TC. TC uptake was linear for 150 sec in both culture conditions.

Neville R. Pimstone – 1 March 1985

Gabriel Garcia, George Scullard, Coleman Smith, Jed Weissberg, Steven Alexander, William S. Robinson, Peter Gregory, Thomas C. Merigan – 1 March 1985

Hidekazu Tsukamoto, Samuel W. French, Nancy Benson, George Delgado, G. Ananda Rao, Edward C. Larkin, Corey Largman – 1 March 1985 – Blood alcohol levels (BAL) were maintained at high levels (overall mean ± S.D. achieved in 14 alcoholic rats was 216.0 ± 120.1 mg%) in male Wistar rats for 15 to 85 days by continuous intragastric infusion of ethanol and nutritionally defined low fat liquid diet. The ethanol intake was progressively increased from 32% of total calories up to 41.4% in order to maintain high BAL. Pair‐fed animals received isocaloric glucose solution and the liquid diet.