J. Fred Dice – 1 May 1985 – The age‐associated decjline in function of several organs, including the liver, may be caused by mechanisms operating on the cellular level. Fibroblasts and several other cell types derived from normal individuals have limited lifespans in culture, and several abnormalities described for senescent cultured fibroblasts also apply to hepatocytes and other cell types obtained from aged organisms.
K. Robert McIntire – 1 May 1985
Susan Jo Burwen, Mary E. Barker, Ira S. Goldman, Albert L. Jones – 1 March 1985 – Epidermal growth factor (EGF), taken up by rat liver hepatocytes, is primarily transported to the lysosomes and degraded. However, a small but significant percentage of endocytosed EGF is transported by a nonlysosomal pathway and is secreted intact into bile. There is no information as to the mechanisms that regulate the selection of transport pathway and thereby determine the different metabolic fates for EGF.
Nathalie Serbource‐Goguel/Seta, Béatrice Borel, Michèle Dodeur, Pierre Scarmato, Benoit Bourel, Jeanne Feger, Geneviève Durand – 1 March 1985 – Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.
Peter Thomas, Paul F. O'Neil, Norman Zamcheck – 1 March 1985 – The biliary output of carcinoembryonic antigen (CEA) in bile fistula rats following treatment with the microtubule poisons vinblastine and colchicine increased 3‐fold over a 4‐hr period. Cytochalasin B and the inactive colchicine derivative lumicolchicine had no effect. These treatments did not effect the rate of CEA clearance from the circulation. Biliary output of low molecular weight fragments from CEA degradation was decreased in the presence of colchicine and vinblastine.
Hitoshi Hatano, Fumio Nomura, Kunihiko Ohnishi, Toshihiko Iijima, Akira Hayasaka, Shinji Iida, Hirofumi Koen, Kunio Okuda – 1 March 1985 – To evaluate the respective roles of halothane metabolism and hypoxia in rats with halothane hepatotoxicity, experiments were designed with special reference to blood gas. After pretreatment with phenobarbital (80 mg per kg., i.p.) for four consecutive days, rats were exposed to 1.0% halothane under a mildly hypoxic condition (FiO2 = 14%) for 2 hr.
1 March 1985