Aldehyde dehydrogenase in alcoholic subjects

Kelvin R. Palmer, William J. Jenkins – 1 March 1985 – Hepatic aldehyde dehydrogenase activity is depressed in alcoholic liver disease and may account for the observation that alcoholics develop high blood acetaldehyde concentrations following ethanol. To determine whether this is a specific defect in alcoholics, aldehyde dehydrogenase was studied in liver tissue obtained from three groups of subjects.

Comparison of the phenacetin and aminopyrine breath tests: Effect of liver disease, inducers and cobaltous chloride

Dale A. Schoeller, Alvin N. Kotake, George H. Lambert, Patricia S. Krager, Alfred L. Baker – 1 March 1985 – The phenacetin breath test (PBT) has been proposed as an alternative to the aminopyrine breath test (ABT) for the assessment of hepatic function. To investigate the clinical utility of the PBT, we compared the PBT with the ABT in 9 healthy subjects and 18 patients with biopsy‐proven liver disease.

Effect of chronic ethanol ingestion on hepatic and intestinal acyl coenzyme A:Cholesterol acyltransferase and 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase in the rat

F. Jeffrey Field, John S. Boydstun, Douglas R. Labrecque – 1 January 1985 – Two groups of rats were pair‐fed diets in which 36% of the calories were provided by either ethanol or dextrimaltose. After 60 days on these liquid diets, rats fed ethanol were significantly smaller than control rats fed dextrimaltose. Serum cholesterol levels in ethanol‐fed animals were 20% higher than control rats. Cholestasis was not observed histologically, and serum alkaline phosphatase and bilirubin levels were the same in both groups.

The merck index. An encyclopedia of chemicals, drugs, and biologicals. Tenth Edition. Martha Windholz, Editor; Susan Budavari, Co‐Editor; Rosemary F. Blumetti, Associate Editor, Elizabeth S. Otterbein, Assistant Editor. 2, 067 pp. (including tables and in

Insulin action in cirrhosis

R. Taylor, R. J. Heine, J. Collins, O. F. W. James, K. G. M. M. Alberti – 1 January 1985 – In vivo insulin sensitivity and adipocyte insulin binding and action were assessed in 16 patients with histologically proven hepatic cirrhosis and 11 age‐, weight‐ and sex‐matched normal control subjects. The cirrhotic group displayed impaired oral glucose tolerance, despite an exaggerated serum immunoreactive insulin response, and in vivo insulin resistance as assessed both by the euglycemic hyperinsulinemic clamp and the glucose‐insulin infusion techniques.

Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes

Douglas M. Jefferson, Lola M. Reid, Marie‐Adele Giambrone, David A. Shafritz, Mark A. Zern – 1 January 1985 – To further our studies on collagen gene expression, we have evaluated the molecular basis for the finding that steroids decrease collagen synthesis in cultured hepatocytes. We studied the effects of dexamethasone on primary cultures of adult rat hepatocytes grown on tissue culture plastic in either serum‐supplemented medium or a serum‐free hormonally defined medium.

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