SUblobular compartmentation of pharmacologic events (scope): Metabolic fluxes in periportal and pericentral regions of the liver lobule

Ronald G. Thurman, Frederick C. Kauffman – 1 January 1985 – New techniques have been developed employing microlight guides and miniature O2 electrodes which permit metabolic events to be studied noninvasively in periportal and pericentral zones of the liver lobule. These events include O2 uptake, fat and carbohydrate metabolism, monooxygen‐ation and glucuronidation.

The sunnybrook gallstone study: A double‐blind controlled trial of chenodeoxycholic acid for gallstone dissolution

Murray M. Fisher, Eve A. Roberts, Irvine E. Rosen, Theodore F. Shapero, Lloyd R. Sutherland, Robert S. Davies, Raymond Bacchus, S. Victor Lee – 1 January 1985 – The Sunnybrook Gallstone Study was a randomized, double‐blind, controlled trial of chenodeoxycholic acid treatment over 2 years in 160 patients with radiolucent gallstones. Sixty‐four patients received 750 mg daily, 53 received 375 mg daily and 43 received placebo. Total dissolution of gallstones occurred in 10.9% of patients on 750 mg daily, 13.2% of those on 375 mg daily and in no patient on placebo. The drug was tolerated well.

Pattern and prognosis of liver function test abnormalities during parenteral nutrition in inflammatory bowel disease

Jose M. Bengoa, Stephen B. Hanauer, Michael D. Sitrin, Alfred L. Baker, Irwin H. Rosenberg – 1 January 1985 – The pattern of liver function test abnormalities was examined during total parenteral nutrition (TPN), using both dextrose and fat emulsions as caloric sources, in 92 patients with inflammatory bowel disease. Seventy‐two patients had completely normal tests before TPN while 20 had one or more abnormal liver function tests before TPN was started. Serum bilirubin levels were normal in all patients before TPN; within 2 weeks on TPN, 25% of patients had elevated bilirubin levels.

Prevalence of hbeag and anti‐hbe in chronic active hepatitis, cirrhosis and primary hepatocellular carcinoma in korea

Chung‐Yong Kim, Soon‐Kee Bae, Hie‐Won L. Hann, W. Thomas London, Baruch S. Blumberg – 1 January 1985 – The prevalence of HBeAg was studied in Korean patients with chronic active hepatitis, cirrhosis and primary hepatocellular carcinoma. There is an independent association of HBeAg prevalence with age and diagnosis. These findings are discussed in terms of a developmental model for primary hepatocellular carcinoma which could explain the lower frequency of HBeAg in the cancer cases.

Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes

Douglas M. Jefferson, Lola M. Reid, Marie‐Adele Giambrone, David A. Shafritz, Mark A. Zern – 1 January 1985 – To further our studies on collagen gene expression, we have evaluated the molecular basis for the finding that steroids decrease collagen synthesis in cultured hepatocytes. We studied the effects of dexamethasone on primary cultures of adult rat hepatocytes grown on tissue culture plastic in either serum‐supplemented medium or a serum‐free hormonally defined medium.

Insulin action in cirrhosis

R. Taylor, R. J. Heine, J. Collins, O. F. W. James, K. G. M. M. Alberti – 1 January 1985 – In vivo insulin sensitivity and adipocyte insulin binding and action were assessed in 16 patients with histologically proven hepatic cirrhosis and 11 age‐, weight‐ and sex‐matched normal control subjects. The cirrhotic group displayed impaired oral glucose tolerance, despite an exaggerated serum immunoreactive insulin response, and in vivo insulin resistance as assessed both by the euglycemic hyperinsulinemic clamp and the glucose‐insulin infusion techniques.

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