Nathalie Serbource‐Goguel/Seta, Béatrice Borel, Michèle Dodeur, Pierre Scarmato, Benoit Bourel, Jeanne Feger, Geneviève Durand – 1 March 1985 – Rats with Jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoo‐rosomucoid in serum has been determined.
Susan Jo Burwen, Mary E. Barker, Ira S. Goldman, Albert L. Jones – 1 March 1985 – Epidermal growth factor (EGF), taken up by rat liver hepatocytes, is primarily transported to the lysosomes and degraded. However, a small but significant percentage of endocytosed EGF is transported by a nonlysosomal pathway and is secreted intact into bile. There is no information as to the mechanisms that regulate the selection of transport pathway and thereby determine the different metabolic fates for EGF.
Gloria E. McNeil, Thomas S. Chen, Carroll M. Leevy – 1 January 1985 – Investigations were undertaken to determine effectiveness of 16,16‐dimethyl prostaglandin E2 (dmPGE2) in overcoming the suppressive effects of ethanol and/or indomethacin on hepatic DNA synthesis. Adult litter mate Sprague‐Dawley rats were subjected to sham operation or partial hepatectomy. Immediately after partial hepatectomy, and at 8‐hr intervals for 24 hr, the rats were given: (a) ethanol with and without dmPGE2 or (b) indomethacin with and without ethanol and/or dmPGE2.
Richard J. Kroeger, Roberto J. Groszmann – 1 January 1985 – We have recently shown that maintenance of portal hypertension in rats is highly dependent on high portal blood flow. This study attempts to determine whether portal hypertension, induced in the rat by partial constriction of the portal vein, can be reduced by lowering portal blood flow with a beta blocking agent.
Leslie Zieve, Michael Shekleton, Carolyn Lyftogt, Kay Draves – 1 January 1985 – Four injections of subcoma doses of ammonium acetate, octanoic acid or dimethyl disulfide during the first 24 hr after two‐lobe hepatectomy in normal rats markedly depressed DNA synthesis as reflected by liver thymidine kinase activity or the incorporation of tritiated thymidine into hepatic DNA. Recovery from the depressant effects of the three toxins took 16 to 28 hr.
Robert H. Purcell, John L. Gerin – 1 January 1985