Gastroenterology. Edited by Gary Gitnick. 425 pp. New York: John Wiley, 1983. $35.00.
Henry S. Pohl – 1 November 1984
Activity and Regulation of Low Density Lipoprotein Receptors in a Human Hepatoblastoma Cell Line
George Y. Wu, Catherine H. Wu, Vincent A. Rifici, Richard J. Stockert – 1 November 1984 – The responsiveness of low density lipoprotein (LDL) binding and uptake was measured in a human hepatoblastoma cell line, Hep G2. These cells exhibited both saturable, high‐affinity and nonsaturable low‐affinity components similar to that described for LDL binding in other mammalian cells. In addition, receptor‐mediated uptake of [125I]LDL was dependent on the presence of Ca++ and required intact lysine residues in LDL as evidenced by abolition of binding following reductive methylation of LDL.
Close Association Between Basal Cell Layer Antibodies and Hepatitis B Virus‐Associated Chronic Delta Infection
Daniela Zauli, Marco Fusconi, Cristina Crespi, Francesco B. Bianchi, Antonio Craxi, Emilio Pisi – 1 November 1984 – Antibodies reacting in immunofluorescence with the basal cell layer of rat forestomach (BCLA) have been detected in 36 of 121 (30%) hepatitis B virus (HBV)‐mediated chronic liver disease (CLD), in 1 of 30 (3%) HBV‐negative CLD, in 3 of 36 (8%) alcoholic liver disease (with no correlation with serum HBV markers), in 1 of 25 (4%) primary biliary cirrhosis, in none of 19 HBV‐related HBsAg‐negative CLD and 60 healthy blood donors.
Reminiscences and Reflections. By Hans Krebs in collaboration with Anne Martin. 250 pp. New York: Oxford University Press, 1982. $19.95.
Charles S. Davidson, Richard L. Veech – 1 November 1984
The Neurobiology of Hepatic Encephalopathy
E. Anthony Jones, Daniel F. Schafer, Peter Ferenci, S. Chris Pappas – 1 November 1984
Detection of Anti‐HBc IgM Following Prednisone Treatment in Patients with Chronic Active Hepatitis B Virus Infection
Marek J. Nowicki, Myron J. Tong, Prem V. Nair, Douglas Stevenson – 1 November 1984 – The effect of a short course of prednisone therapy on serum IgM type antibody to the hepatitis B core antigen (anti‐HBc IgM) was studied in 14 male patients with chronic active type B hepatitis. Eleven patients (78.5%) became positive for serum anti‐HBc IgM either during or shortly after prednisone withdrawal. Detection of anti‐HBc IgM correlated with an increase in hepatitis B virus specific DNA‐polymerase activity and was followed by a rise in serum transaminase levels.
Liver Orcein Stain and Viral DNA in Duck Hepatitis B Virus Infection in Chinese Ducks and Experimentally Infected Japanese Ducklings
Junko Mori, Masao Omata, Osamu Yokosuka, Fumio Imazeki, Yoshimi Ito, Katsuo Uchiumi, Yasuhisa Matsuyama, Ye Weifa, Kunio Okuda – 1 November 1984 – Liver sections were stained with orcein, and duck hepatitis B virus was identified in sera and livers by the hybridization technique in 106 ducks (44 Chinese ducks, 15 Japanese ducks and 47 Japanese ducklings). Orcein‐positive hepatocytes were found in 18 of 38 (47%) duck hepatitis B virus DNA seropositive ducks, and only in 3 of 68 (4%) seronegative ducks. The three ducks were all from a heavily infected flock in southern China.
Clinical Significance of Enhanced Detection of HBsAg by a Monoclonal Radioimmunoassay
Edna Ben‐Porath, Jack Wands, Mignon Gruia, Kurt Isselbacher – 1 November 1984 – We assessed the significance of the enhanced detection by monoclonal radioimmunoassay (M‐RIA) of HBsAg in serum of patients with hepatitis B virus (HBV) infection. In acute HBV infection, the M‐RIA detected HBsAg in the blood for a far longer period of time than previously recognized. In some patients, the “window phase” of HBV infection (defined as the presence of anti‐HBc and the lack of detectable HBsAg and anti‐HBs) was shortened or completely eliminated.